Metrics

  • citations in SCIndeks: [1]
  • citations in CrossRef:[4]
  • citations in Google Scholar:[]
  • visits in previous 30 days:12
  • full-text downloads in 30 days:5

Contents

article: 1 from 1  
2020, vol. 39, iss. 4, pp. 452-459
Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
aHitit University, Faculty of Science and Arts, Department of Molecular Biology and Genetics, Corum, Turkey
bHitit University, Faculty of Medicine, Department of Internal Medicine, Corum, Turkey
cHigh Education University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey

emailavci.emre@yahoo.com
Abstract
Background: Obesity is responsible for high morbidity and mortality, both in developed and developing countries. It is associated with many chronic and metabolic diseases. Asymmetric dimethylarginine (ADMA) has been demonstrated to be a biomarker of endothelial dysfunction in humans and increased ADMA associated with cardiovascular disease (CVD) risk has been reported in many states. Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-g) is emphasized in recent findings. The current study aims to investigate ADMA and NP levels which may assume a role in guiding the early diagnosis of coronary artery disease in obesity. Methods: This is an original research study in which ADMA and NP levels of 50 patients (25 male/25 female) diagnosed with obesity were compared with those of 30 healthy individuals (15 male/15 female) as control. The high-performance liquid chromatography (HPLC) method was used while determining parameters. Results: ADMA and NP levels in obese individuals were found to be significantly higher than in those enrolled in the control. ADMA values were found to be higher in obese subjects (0.71±0.24 mmol/L) as compared with levels found in healthy subjects (0.58±0.16 mmol/L) (p<0.05). A significant increase of serum neopterin levels was found in obese subjects (8.8±3.5 mmol/L) as compared with controls (4.9±1.69 mmol/L) (p<0.05). Also, there was a strong positive correlation between NP and ADMA values in obese individuals (r=0.954). Conclusions: Our study revealed that obese subjects have higher ADMA and neopterin levels. These results demonstrated that both ADMA and NP levels may be potential risk factors for coronary heart disease in obesity.
References
Agacayak, E., Tunc, S.Y., Sak, S., Basaranoglu, S., Yüksel, H., Turgut, A., Gul, T. (2015) Levels of neopterin and other inflammatory markers in obese and non-obese patients with polycystic ovary syndrome. Med Sci Monit, 21: 2446-55
Anderssohn, M., Schwedhelm, E., Lüneburg, N., Vasan, R.S., Böger, R.H. (2010) Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: An intriguing interaction with diabetes mellitus. Diabetes and Vascular Disease Research, 7(2): 105-118
Avcı, E., Coskun, C.S., Cakır, E., Yaman, H., Bilgi, C. (2014) Determination of oxidative stress and cellular immunity in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure. Renal Failure, 36 (5): 776-3
Avcı, E., Coşkun, Ş., Çakır, E., Kurt, Y., Akgül, E.Ö., Bilgi, C. (2008) Relations between concentrations of asymmetric dimethylarginine and neopterin as potential risk factors for cardiovascular diseases in haemodialysis-treated patients. Renal Failure, 30(8): 784-790
Barthelmes, J., Nägele, M.P., Ludovici, V., Ruschitzka, F., Sudano, I., Flammer, A.J. (2017) Endothelial dysfunction in cardiovascular disease and Flammer syndrome: Similarities and differences. EPMA Journal, 8(2): 99-109
Baskın, Y., Yiğitbaşı, T., Afacan, G., Bağbozan, Ş. (2008) İnsülin direnci olan erişkin kilolu ve obezlerde lipoprotein (a) ile lipid parametreleri. Türk Klinik Biyokimya Derg, 6(2): 65-71
Bekçi, T.T., Kesli, R., Koçak, N. (2010) Serum neopterin levels in obese and nonobese patients with obstructive sleep apnea syndrome. Journal of Inonu University Faculty of Medicine, 17(3): 165-8
Bhurosy, T., Jeewon, R. (2014) Overweight and obesity epidemic in developing countries: A problem with diet, physical activity, or socioeconomic status?. Scientific World Journal, 2014: 1-7, 964236
Dückelmann, C., Mittermayer, F., Haider, D.G., Altenberger, J., Eichinger, J., Wolzt, M. (2007) Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(9): 2037-2042
Eberhard, R. (2007) Total cardiovascular risk management. Am J Cardiol, 100: 53-60
Eid, H.M.A., Arnesen, H., Hjerkinn, E.M., Lyberg, T., Seljeflot, I. (2004) Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine. Metabolism, 53(12): 1574-1579
el Assar, M., Angulo, J., Santos-Ruiz, M., Ruiz, de A.J.C., Pindado, M.L., Sánchez-Ferrer, A.L., Hernández, A., Rodríguez-Mañas, L. (2016) Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans. Journal of Physiology, 594(11): 3045-3060
el Assar, M., Ruiz, de A.J.C., Angulo, J.C., Pindado, M.M.L., Hernández, M.A., Rodríguez-Mañas, L. (2013) Preserved endothelial function in human obesity in the absence of insulin resistance. Journal of Translational Medicine, 11(1): 263-263
Engin, A.B. (2017) Adipocyte-macrophage cross-talk in obesity. in: Adv. exp. med. biol: Obesity and lipotoxicity, 960: 327-343
Erdoğmuş, F., Koca, C., Selçoki, Y., Karakurt, F., Aydın, M., Çarlıoğlu, A., Eryonucu, B., Yiğitoğlu, R. (2009) Metabolik Sendromda Endotel Disfonksiyonu ve Ateroskleroz Riski Arasındaki İlişkinin Oksidatif Stres Üzerinden Değerlendirilmesi. Turkiye Klinikleri J Cardiovasc Sci, 21(1)
Grammer, T.B., Fuchs, D., Boehm, B.O., Winkelmann, B.R., Maerz, W. (2009) Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography in the Ludwigshafen Risk and Cardiovascular Health Study. Clinical Chemistry, 55(6): 1135-1146
Hajar, R. (2016) Framingham contribution to cardiovascular disease. Heart Views, 17(2): 78-81
Huang, F., del-Río-Navarro Blanca, E., Pérez, O.J.A., Ruiz-Bedolla, E., Navarro-Olivos, E., Villafaña, S., Bravo, G., Hong, E. (2013) Changes in ghrelin and asymmetrical dimethylarginine in obese Mexican adolescents after six-month lifestyle intervention. Endocrine, 43(3): 603-610
Jackson, V. M., Breen, D.M., Fortin, J., Liou, A., Kuzmiski, J. B., Loomis, A. K., Rives, M., Shah, B., Carpino, P.A. (2015) Latest approaches for the treatment of obesity. Expert Opinion on Drug Discovery, 10(8): 825-839
Kabaroğlu, C., Ersoy, B., Onur, E., Özhan, B., Erdin, S., Var, A., Bayındır, O., Dinç, G. (2013) Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: A new disorder of glucose tolerance. Endocrine Journal, 60(2): 197-205
Kocak, H., Oner-Iyidogan, Y., Gurdol, F., Oner, P., Esin, D. (2011) Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women. Journal of Clinical Laboratory Analysis, 25(3): 174-178
Koliaki, C., Liatis, S., Kokkinos, A. (2019) Obesity and cardiovascular disease: Revisiting an old relationship. Metabolism, 92: 98-107
Krzyzanowska, K., Mittermayer, F., Kopp, H., Wolzt, M., Schernthaner, G. (2004) Weight loss reduces circulating asymmetrical dimethylarginine concentrations in morbidly obese women. Journal of Clinical Endocrinology & Metabolism, 89(12): 6277-6281
Liu, X., Hou, L., Xu, D., Chen, A., Yang, L., Zhuang, Y., Xu, Y., Fassett, J.T., Chen, Y. (2016) Effect of asymmetric dimethylarginine (ADMA) on heart failure development. Nitric Oxide, 54: 73-81
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G.A., Beguinot, F., Miele, C. (2019) Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. International Journal of Molecular Sciences, 20(9), pii: E2358
Mangge, H., Almer, G., Truschnig-Wilders, M., Schmidt, A., Gasser, R., Fuchs, D. (2010) Inflammation, adiponectin, obesity and cardiovascular risk. Current Medicinal Chemistry, 17(36): 4511-4520
Mangge, H., Freytag, F., Almer, G., Weghuber, D., Bauer-Denk, C., Fuchs, D. (2011) Serum neopterin is not increased in obese juveniles. Journal of Obesity, 2011: 1-7, 946795
Marliss, E.B., Chevalier, S., Gougeon, R., Morais, J.A., Lamarche, M., Adegoke, O.A.J., Wu, G. (2006) Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. Diabetologia, 49(2): 351-359
Mathieu, P., Poirier, P., Pibarot, P., Lemieux, I., Després, J.P. (2009) Visceral obesity: The link among inflammation, hypertension, and cardiovascular disease. Hypertension, 53(4): 577-84
Matsubara, M., Maruoka, S., Katayose, S. (2002) Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. European Journal of Endocrinology, 147(2): 173-180
Mclaughlin, T., Stühlinger, M., Lamendola, C., Abbasi, F., Bialek, J., Reaven, G.M., Tsao, P.S. (2006) Plasma asymmetric dimethylarginine concentrations are elevated in obese insulin-resistant women and fall with weight loss. Journal of Clinical Endocrinology & Metabolism, 91(5): 1896-1900
Nageswara, R.G.S., Gurumurthy, P.E.S., Cherian, K.M. (2013) The clinical and biochemical parameters in relation to the serum neopterin levels in Indian children and adolescents. J Clin Diagn Res, 7(4): 618-21
Nakhjavani, M., Karimi-Jafari, H., Esteghamati, A., Khalilzadeh, O., Asgarani, F., Ghadiri-Anari, A. (2010) ADMA is a correlate of insulin resistance in early-stage diabetes independent of hs-CRP and body adiposity. Annales d'Endocrinologie, Paris, 71(4): 303-308
Oishi, J.C., Castro, C.A., Silva, K.A., Fabricio, V., Cárnio, E.C., Phillips, S.A., Duarte, A.C.G.de O., Rodrigues, G.J. (2018) Endothelial dysfunction and inflammation precedes elevations in blood pressure induced by a high-fat diet. Arquivos Brasileiros de Cardiologia, 110(6): 558-67
Poobalan, A., Aucott, L. (2016) Obesity among young adults in developing countries: A systematic overview. Current Obesity Reports, 5(1): 2-13
Prieto, D., Contreras, C., Sanchez, A. (2014) Endothelial dysfunction, obesity and insulin resistance. Current Vascular Pharmacology, 12(3): 412-426
Şentürk, B.A., Üstüner, F., Aksu, S., Sülek, Z. (2005) Plasminojen Aktivatör Ünhibitör Tip I, İnsülin Direnci ve Android Obezite. Türk Klinik Biyokimya Derg, 3(3):109-15
Shuldiner, A.R., Yang, R., Gong, D. (2001) Resistin, obesity, and insulin resistance: The emerging role of the adipocyte as an endocrine organ. New England Journal of Medicine, 345(18): 1345-1346
Spencer, M.E., Jain, A., Matteini, A., Beamer, B.A., Wang, N.-Y., Leng, S.X., Punjabi, N.M., Walston, J.D., Fedarko, N.S. (2010) Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65A(8): 858-865
Ursavaş, A., Karadag, M., Oral, A.Y., Demirdogen, E., Oral, H.B., Ege, E. (2008) Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea. Respiratory Medicine, 102(8): 1193-1197
Yuniarty, D., Santoso, A., Arif, M. (2011) Correlation of neopterin and TNF-alpha with asymmetric dimethylarginine in metabolic syndrome. Indonesian Biomedical Journal, 3(3): 200-203
 

About

article language: English
document type: Original Scientific Paper
PMC ID: PMC7710377
DOI: 10.5937/jomb0-24683
published in SCIndeks: 02/10/2020
peer review method: double-blind
Creative Commons License 4.0

Related records

No related records