Serbian Journal of Experimental and Clinical Research
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The effect of serotonergic lesions in the medial prefrontal cortex on psychotomimetic drug-induced locomotor hyperactivity and prepulse inhibition in rats
(naslov ne postoji na srpskom)
aDepartment of Nursing, University of Melbourne, Carlton, Victoria, Australia + Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria, Australia
bBehavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria, Australia + Department of Pharmacology, University of Melbourne, Carlton, Victoria, Australia

Ključne reči: schizophrenia; serotonin; medial prefrontal cortex; prepulse inhibition
(ne postoji na srpskom)
While dysfunction of the prefrontal cortex has been repeatedly implicated in the pathophysiology of schizophrenia, the role of serotonin in this brain region in schizophrenia is unclear. We therefore examined the effects of local serotonin depletion in the medial prefrontal cortex on psychotomimetic drug-induced locomotor hyperactivity and prepulse inhibition, two animal models of aspects of schizophrenia. Pentobarbital-anaesthetised (60 mg/kg, i.p.) male Sprague-Dawley rats were stereotaxically micro-injected with 0.5 μl of a 5 μg/μl solution of the serotonin neurotoxin 5,7-dihydroxytryptamine into the medial prefrontal cortex. Two weeks after the surgery, rats underwent behavioural testing. When compared to sham-operated controls, rats with me dial prefrontal cortical lesions did not show changes in either psychotomimetic drug-induced locomotor hyperactivity or prepulse inhibition. However, following the administration of the serotonin neurotoxin into the medial prefrontal cortex, the concentration of serotonin was reduced by 60%. These results suggest that serotonin depletion in the medial prefrontal cortex does not lead to dysregulation of subcortical dopaminergic activity and does not cause aberrant responses to environmental stimuli.
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DOI: 10.5937/sjecr1101011K
objavljen u SCIndeksu: 22.06.2011.