Metrika

  • citati u SCIndeksu: [1]
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:8
  • preuzimanja u poslednjih 30 dana:0

Sadržaj

članak: 1 od 1  
2012, vol. 62, br. 2, str. 92-100
Neželjeni efekti i toksičnost analgetika
Univerzitet u Beogradu, Farmaceutski fakultet, Institut za toksikološku hemiju

e-adresazorica.bulat@pharmacy.bg.ac.rs
Projekat:
Unapređenje i razvoj higijenskih i tehnoloških postupaka u proizvodnji namirnica životinjskog porekla u cilju dobijanja kvalitetnih i bezbednih proizvoda konkurentnih na svetskom tržištu (MPNTR - 46009)

Sažetak
U ovom radu obrađeni su acetilsalicilna kiselina, paracetamol i ibuprofen, s obzirom da su među najšire korišćenim analgoantipireticima koji i pored neosporno potvrđenog farmakološkog dejstva mogu biti uzročnici trovanja, pa i smrti. Acetilsalicilna kiselina i paracetamol su najčešće korišćeni lekovi koji se izdaju bez recepta, a izveštaji centara za kontrolu trovanja opominju na rizik koji nose ovi COX inhibitori. Poznato je da acetilsalicilna kiselina dovodi do produžene inhibicije koagulacije krvi, metaboličke acidoze i drugih toksičnih efekata, a da se toksičnost paracetamola prvenstveno ispoljava na jetri. Trovanja ibuprofenom su znatno ređa, posebno sa smrtnim ishodom. Pri predoziranju ibuprofenom dominiraju gastrointestinalne smetnje, a može doći i do renalnog oštećenja.
Reference
Blakely, P., McDonald, B.R. (1995) Acute renal failure due to acetaminophen ingestion: A case report and review of the literature. Journal of the American Society of Nephrology, 6(1): 48-53
Bronstein, A.C., Spyker, D.A., Cantilena, L.R., Green, J.L., Rumack, B.H., Heard, S.E. (2008) Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th annual report. Clin Toxicol, 46: 927-1057
Bronstein, A.C., Spyker, D.A., Cantilena, L.R., Green, J.L., Rumack, B.H., Dart, R.C. (2011) Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 28th Annual Report. Clin Toxicol, 49: 910-941
Brune, K., Hinz, B., Otterness, I. (2009) Aspirin and acetaminophen: Should they be available over the counter?. Current rheumatology reports, 11(1): 36-40
Chun, L.J., Tong, M.J., Busuttil, R.W., Hiatt, J.R. (2009) Acetaminophen hepatotoxicity and acute liver failure. Journal of clinical gastroenterology, 43(4): 342-9
Chyka, P.A., Erdman, A.R., Christianson, G., Wax, P.M., Booze, L.L., Manoguerra, A.S., Martin, C.E., Nelson, L.S., Olson, K.R., Cobaugh, D.J., Scharman, E.J., Woolf, A.D., Troutman, W.G. (2007) Salicylate poisoning: An evidence-based consensus guideline for out-of-hospital management*. Clinical Toxicology, 45(2): 95-131
Dargan, P., Jones, A. (2002) Paracetamol: Balancing risk against benefit. QJM, 95(12): 831-832
Dargan, P.I., Wallace, C.I., Jones, A.L. (2002) An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose. Emergency medicine journal, 19(3): 206-9
Dart, R.C., Rumack, B.H. (2012) Intravenous Acetaminophen in the United States: Iatrogenic Dosing Errors. Pediatrics, 129(2): 349-353
Flomenbaum, N.E. (2006) Salicylates. u: Flomenbaum N.E., Howland M.A., Hoffman R.S. [ur.] Goldfrank's toxicologic emergencies, London: McGraw-Hill Professional, 8th edn
Gunn, V.L., Taha, S.H., Liebelt, E.L., Serwint, J.R. (2001) Toxicity of over-the-counter cough and cold medications. Pediatrics, 108(3): E52
Hawkins, L.C., Edwards, J.N., Dargan, P.I. (2007) Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: A review of the literature. Drug safety, 30(6): 465-79
Kim, S. (2004) Salicylates. u: Olson K.C. [ur.] Poisoning and drug overdose, New York: Lange Medical Books, p. 331-3; 4rd edn
Matović, V. Toksikološki aspekti analgetika: Asprina, paracetamola i ibuprofena. Arh farm, 5: 611-618
Moore, N. (2007) Ibuprofen: A journey from prescription to over-the-counter use. J R Soc Med, Suppl 48(100): 2-6
Morgan, O., Majeed, A. (2005) Restricting paracetamol in the United Kingdom to reduce poisoning: A systematic review. Journal of Public Health, 27(1): 12-18
Olson, K.C. (2004) Acetaminophen. u: Olson K.C. [ur.] Poisoning and drug overdose, New York: Lange Medical Books, p. 66-9; 4rd edn
Ozanne-Smith, J., Routley, V., Scott, I., Scott, G. (2002) Pharmaceutical poisonings to year olds. Victoria: National Public Health Partnership Public Health Planning and Practice Framework Trial. Monash University Accident Research Centre, Nov; Report No. 193
Rang, H.P., Dale, M.M., Ritter, J.M., Moore, P.K. (2005) u: Todorović Z. [ur.] Pharmacology, Beograd: Data status, 5. izdanje
Rowden, A.K., Norvell, J., Eldridge, D.L., Kirk, M.A. (2006) Acetaminophen poisoning. Clinics in laboratory medicine, 26(1): 49-65, viii
Sandilands, E., Bateman, D.N. (2008) Analgesics. Clin Med., Feb; 8(1):96-9
Schilling, A., Corey, R., Leonard, M., Eghtesad, B. (2010) Acetaminophen: Old drug, new warnings. Cleveland Clinic journal of medicine, 77(1): 19-27
Tai, W.W. (2004) Nonsteroidal anti-inflammatory drugs. u: Olson K.C. [ur.] Poisoning and drug overdose, New York: Lange Medical Books, p. 283-6; 4rd edn
Volans, G., Monaghan, J., Colbridge, M. (2003) Ibuprofen overdose. Int J Clin Pract,l, Suppl(135):54- 60
 

O članku

jezik rada: srpski
vrsta rada: stručni članak
objavljen u SCIndeksu: 22.03.2013.

Povezani članci