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2011, vol. 58, br. 2, str. 67-74
Molekularnobiološke osobine oralnih skvamocelularnih karcinoma
aUniverzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković'
bUniverzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča
cUniverzitet u Beogradu, Stomatološki fakultet
dKliničko-bolnički centar Zvezdara, Beograd

e-adresajelena_milasin@yahoo.com
Projekat:
Genetička kontrola i molekularni mehanizmi u malignim, inflamatornim i razvojnim patologijama orofacijalne regije (MPNTR - 175075)

Ključne reči: oralni karcinomi; kancerski geni; virusna infekcija; hipermetilacija; predispozicija
Sažetak
Oralne skvamocelularne karcinome (OSCK) odlikuje uglavnom loša prognoza i, uprkos pomacima u terapijskim postupcima, poslednjih godina nije ostvaren napredak u preživljavanju osoba s ovim tumorom. Velike nade se polažu u molekularnu medicinu i pronalaženje novih bioloških markera pomoću kojih bi preciznije nego što to dopuštaju klinički i histopatološki parametri moglo da se predvidi ponašanje tumora. OSCK, kao i većina drugih malignih oboljenja, rezultat su postupne akumulacije raznovrsnih genetičkih i epigenetičkih promena u ćelijama, koje od normalnih postaju neoplastične. U ovom radu dat je presek nekih od pravaca istraživanja na polju molekularne biologije oralnih karcinoma, s osvrtom na studije koje se bave ispitivanjem somatskih mutacija u kancerskim genima, učešćem onkogenih virusa u patogenezi i značaju procesa metilacije za OSCK. Takođe su pomenute studije posvećene utvrđivanju eventualnog postojanja predispozicije za razvoj OSCK.
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O članku

jezik rada: engleski, srpski
vrsta rada: pregledni članak
DOI: 10.2298/SGS1102067T
objavljen u SCIndeksu: 07.09.2011.

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