The paper reviews possibilities of application of structural performance-based methods for production of geometrically complex, non-conventional architectural forms. Starting from the fact that advanced digital technologies and multidisciplinary approach have significantly changed traditional relations in design process, this work indicates at potentials of application of methods, procedures and tools initially not designed for architectural production. Based on biological paradigm, morphogenetic strategies in the field of architecture represent dynamic operation-based form-finding methods. The focus of the paper will be on conceptualization of morphogenetic procedure for production of integrated morphologic solutions which are characterized by optimal form-structure interdependence. The procedure is based on isogeometric concept, which enables integration of CAD and FEA. Compared to the conventional FEA, in which geometric interpolation is carried, the isogeometry analysis is based on exactly defined initial geometry, thus enabling design, analysis and refinement of models by using a single data type, which considerably facilitates and accelerates the process of repeated analysis of variant forms. The objective of this paper is to confirm the thesis that transposition, advancement and integration of creative tools affect reconsideration of conventional approaches, methods and procedures, thus enabling innovation and optimization of the design process.