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2003, vol. 60, br. 3, str. 353-360
Fulminantni hepatitis B
Vojnomedicinska akademija, Klinika za infektivne i tropske bolesti, Beograd
Sažetak
Fulminantni hepatitis ili fulminantna insuficijencija jetre se definiše kao klnički sindrom izraženog oštećenja funkcije jetre koji dovodi do kome i smanjenja sintetskog kapaciteta jetre, a razvija se u toku osam nedelja od početka hepatitisa. Više nezavisnih faktora utiče na preživljavanje uključujući starost bolesnika, uzrok oboljenja jetre, stepen izraženosti i trajanje encefalopatije u odnosu na početak bolesti, kao i prevencija komplikacija. Tokom vremena mnogi terapijski tretmani su primenjeni u lečenju. Transplantacija je skupa, a bolesnicima koji prežive transplantaciju neophodna je doživotna imunosupresija, klinička nega i lečenje komplikacija. Bez transplantacije insuficijentna jetra može biti kompletno oporavljena, a nakon spontanog oporavka može se normalno živeti. Prikazali smo dva slučaja fulminantnog B hepatitisa koji su, uprkos lošoj prognozi, preživeli uz intenzivni tretman. Medicinski tretman bolesnika sa fulminantnim hepatitisom iziskuje intenzivni nadzor i intenzivne terapijske mere koje uključuju i kortikosteroide. Prognoza kod fulminantog hepatitisa gledana kroz preživljavanje, a bez transplantacije, omeđena je merama medicinskog tertmana i novim specifičnim terapijskim modalitetima koji moraju biti razvijeni kroz bazična istraživanja.
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O članku

jezik rada: srpski
vrsta rada: prikaz slučaja
DOI: 10.2298/VSP0303353D
objavljen u SCIndeksu: 02.06.2007.

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