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2009, vol. 66, br. 12, str. 955-960
Klinička, morfološka i imunohistohemijska analiza limfoidnog poremećaja u parotidnoj žlezdi kod bolesnika sa Sjegrenovim sindromom
aKlinički centar Niš, Klinika za očne bolesti
bUniverzitet u Nišu, Medicinski fakultet, Katedra Patologija
cUniverzitet u Nišu, Medicinski fakultet, Katedra Maksiofacijalna hirurgija i oralna hirurgija

e-adresamarija.trenkic@gmail.com
Sažetak
Uvod/Cilj. Sjegrenov sindrom je hronična autoimuna sistemska bolest okarakterisana poliglandularnom tkivnom destrukcijom, suvim keratitisom i suvim ustima. Ovi bolesnici imaju 44 puta veći rizik od razvoja limfoma, pri čemu je kod 80% njih prisutan MALT tip. Zbog nejasnih kriterijuma za razlikovanje benignih limfoepitelnih lezija pljuvačnih žlezda od MALT limfoma, cilj ove analize bio je obezbeđivanje praktičnih, kliničkih, histopatoloških i imunohistohemijskih informacija o njima. Metode. Od 32 parotidektomije, kod 27 nađen je Sjegrenov sijaloadenitis, a kod 5 MALT limfom. Laboratorijski preseci debljine 4 μm bojeni su hematoksilin/eozin (HE), Van Gieson, AB-PAS i LSAB2 metodama, uz korišćenje antitela na: CD3, CD20, kappa i lambda lake lance i panCytokeratin antigene. Rezultati. Analizom je bilo obuhvaćeno 27 bolesnika (22 žene i 5 muškaraca) sa Sjegrenovim sijalodenitisom i pet bolesnika (samo žene) sa MALT limfomom. U skladu sa Ann Harbor klasifikacijom svi bolesnici sa MALT limfomom bili su u stadijumu IE. Obe grupe bolesnika imale su blagi klinički tok, sem bržeg povećanja jedne parotidne žlezde kod onih sa limfomom. Za razliku od benignih limfoepitelnih lezija, MALT limfom odlikovao se difuznim i gustim monoklonskim B-ćelijskim infiltratom, uz brisanje normalne građe pljuvačne žlezde i malignim limfoepitelnim lezijama infiltrovanim monoklonskim tipom B limfocita potpuno ili delimično. Maligne limfoepitelne lezije, prikazane kao infiltracije duktusnih i epitelnih struktura monoklonskim neoplastičnim B-ćelijama pozitivnim na CD 20, prikazale su se pomoću antitela na citokeratin. Zaključak. Za optimalnu dijagnozu MALT limfoma pljuvačne žlezde neophodni su klinički, morfološki i imunohistohemijski nalazi.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/VSP0912955T
objavljen u SCIndeksu: 12.01.2010.

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