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2010, vol. 67, br. 7, str. 573-578
Uticaj sumpornih kupki i pakovanja blata na oksidativni stres, sadržaj hemoglobina i aktivnost superoksid-dismutaze i katalaze kod bolesnika sa osteoartritisom
aSpecialized Hospital for Rehabilitation, Banja Koviljača
bSchool of Medicine, Department of Medical Ecology and Hydroclimatology, Istanbul University, Istanbul, Turkey
cUniverzitet u Beogradu, Medicinski fakultet, Institut za epidemiologiju
dUniverzitet u Beogradu, Biološki fakultet, Institut za biologiju i biohemiju

e-adresajokic71@gmail.com
Sažetak
Uvod/Cilj. Poznato je da sumporne kupke i pakovanja blata imaju povoljno delovanje kod bolesnika sa osteoartritisom (OA) kolena i kuka zahvaljujući povišenoj aktivnosti antioksidantnih zaštitnih enzima. Cilj ove studije bio je praćenje nivoa lipidne peroksidacije, tj. koncentracije malondialdehida, kod bolesnika sa osteoartritisom (OA) kolena i/ili kuka, kao i utvrđivanje uticaja sumporne kupke i blatnog pakovanja na aktivnost superoksid-dismutaze (SOD) i katalaze (CAT) sa ciljem da ublaže ili eliminiše oksidativni stres. Metode. Bolesnici sa OA kolena i/ili kuka oba pola (n = 31) bili su uključeni u studiju. Svi bolesnici dobijali su blatna pakovanja i sumporne kupke 20 minuta dnevno, šest dana u nedelji, ukupno tri nedelje. Nivo lipidne peroksidacije u krvi, tj. koncentracija malondialdehida, aktivnost superoksid-dismutaze i katalaze mereni su spektrofotometrijski, pre tretmana, petog dana lečenja i na kraju tretmana. Kontrolnu grupu činile su 33 zdrave osoba. Rezultati. Tretman blatnim pakovanjima i sumpornim kupkama kod bolesnika sa OA izazvao je značajno sniženje koncentracije malondialdehida u plazmi u poređenju sa kontrolnom grupom (p < 0,001). Prosečna vrednost aktivnosti SOD bila je 1 836,24 IJ/gHb pre početka tretmana, 5. dana porasla je na 1 942,15 IJ/gHb i nakon spa tretmana opala na 1 745,98 IJ/gHb. Aktivnost katalaze pre terapija bila je 20,56 kIJ/gHb, a na kraju tretmana 16,16 kIJ/gHb. Razlika u aktivnosti katalaze pre i posle terapije bila je značajna (p < 0,001), a takođe je značajna i u poređenju sa kontrolnom grupom (p < 0,001). Na kraju lečenja došlo je do značajnog porasta nivoa hemoglobina i značajnog smanjenja bola i povećanje obima pokreta u zahvaćenom zglobu. Zaključak. Sumporne kupke u kombinaciji sa pakovanjima blata tokom tronedeljnog tretmana dovele su do značajnog smanjenja stepena lipidne peroksidacije u plazmi i smanjenja intenziteta bola kod obolelih od OA. Ovo je bilo praćeno promenama u aktivnosti antioksidantnih enzima, SOD i CAT i porastom nivoa hemoglobina, što ukazuje na njihovu ulogu u postignutom terapijskom efektu banjskg treatmana.
Reference
Altman, R., Alarcón, G., Appelrouth, D., Bloch, D., Borenstein, D., Brandt, K., Brown, C., Cooke, T.D., Daniel, W., Feldman, D. (1991) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis and rheumatism, 34(5): 505-14
Altman, R., Asch, E., Bloch, D., Bole, G., Borenstein, D., Brandt, K., Christy, W., Cooke, T.D., Greenwald, R., Hochberg, M. (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum, 29(8): 1039-49
Andreeva, L.I., Kozhemiakin, L.A., Kishkun, A.A. (1988) Modification of the method of determining lipid peroxidation in a test using thiobarbituric acid. Laboratornoe delo, (11): 41-3
Aruoma, O.I., Kaur, H., Halliwell, B. (1991) Oxygen free radicals and human diseases. Journal of the Royal Society of Health, 111(5): 172-7
Beal, F.M. (2002) Oxidatively modified proteins in aging and disease. Free radical biology & medicine, 32(9): 797-803
Beinert, H. (2000) A tribute to sulfur. European journal of biochemistry / FEBS, 267(18): 5657-64
Bellometti, S., Poletto, M., Gregotti, C., Richelmi, P., Berte, F. (2000) Mud bath therapy influences nitric oxide, myeloperoxidase and glutathione peroxidase serum levels in arthritic patients. Int J Clin Pharmacol Res, 20(3-4): 69-80
Bender, T., Bariska, J., Vághy, R., Gomez, R. (2007) Effect of balneotherapy on the antioxidant system: A controlled pilot study. Archives of medical research, 38(1): 86-9
Beutler, E., ur. (1982) Red Cell Metabolism, A Manual of Biochemical Methods. New York: Grune and Stratton, 105-6
Carlo, M.D., Loeser, R.F. (2003) Increased oxidative stress with aging reduces chondrocyte survival: Correlation with intracellular glutathione levels. Arthritis and rheumatism, 48(12): 3419-30
Carrington, J.L. (2005) Aging bone and cartilage: Cross-cutting issues. Biochemical and Biophysical Research Communications, 328(3): 700
del Carlo, M., Loeser, R.F. (2002) Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis and rheumatism, 46(2): 394-403
Ekmekcioglu, C., Strauss-Blasche, G., Holzer, F., Markth, W. (2002) Effect of sulfur baths on antioxidative defence systems, peroxide concentrations and lipid levels in patients with degenerative osteoarthritis. Forschende Komplement??rmedizin und Klassische Naturheilkunde / Research in Complementary and Classical Natural Medicine, 9(4): 216
Felson, D.T., Zhang, Y. (1998) An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis and rheumatism, 41(8): 1343-55
Finkel, T., Holbrook, N.J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature, 408(6809): 239-47
Guillemin, F., Virion, J.M., Escudier, P., de Talancé, N., Weryha, G. (2001) Effect on osteoarthritis of spa therapy at Bourbonne-les-Bains. Joint, bone, spine, 68(6): 499-503
Halliwell, B., Gutteridge, J.M.C. (1999) Free radicals in biology and medicine. Oxford: Oxford University Press / OUP, 3rd ed
Henrotin, Y.E., Bruckner, P., Pujol, J.P.L. (2003) The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 11(10): 747-55
Hildebrandt, G., Gutenbrunner, C. (1998) Balneologie. u: Hildebrandt G.Gutenbrunner C. [ur.] Handbuch der balneologie und medizinischen klimatologie, Berlin - Heidelberg: Springer, str. 271-3
Jovanović, T., Janjić, M., Popović, G., Conić, S. (1996) Balneoklimatologija. Beograd: Medicinski fakultet
Karagulle, M.Z., Tutuncu, Z.N., Aslan, O., Basak, E., Mutlu, A. (1996) Effects of thermal sulphur bath cure on adjuvant arthritic rats. Physikalische Medizin Rehabilitationsmedizin Kurortmedizin, 6(2): 53
Lehmann, J., Lateur, B. (1994) Ultrasound shortwave microwave laser superficial heat and cold in the treatment of pain. u: Wall P., Melzack R. [ur.] Textbook of pain, London: Churchill Livingstone, str. 1237-46
Loeser, R. (2000) Aging and the etiopathogenesis and treatment of osteoarthritis. Rheumatic Disease Clinics of North America, 26(3): 547
Mapp, P.I., Grootveld, M.C., Blake, D.R. (1995) Hypoxia, oxidative stress and rheumatoid arthritis. Br Med Bull, 51(2): 419-36
Martin, J.A., Buckwalter, J.A. (2002) Aging, articular cartilage chondrocyte senescence and osteoarthritis. Biogerontology, 3(5): 257
Martin, J.A., Brown, T., Heiner, A., Buckwalter, J.A. (2004) Post-traumatic osteoarthritis: The role of accelerated chondrocyte senescence. Biorheology, 41(3,4), 479-491
Mazzetti, I., Grigolo, B., Pulsatelli, L., Dolzani, P., Silvestri, T., Roseti, L., Meliconi, R., Facchini, A. (2001) Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis. Clinical science (London, England : 1979), 101(6): 593-9
Mccartney-Francis, N.L., Song, X.Y., Mizel, D.E., Wahl, C.L., Wahl, S.M. (1999) Hemoglobin protects from streptococcal cell wall-induced arthritis. Arthritis and rheumatism, 42(6): 1119-27
Misra, H.P., Fridovich, I. (1972) The role of the superoxide anion in the autooxidation of epinephrine and simple assay for superoxide dismutase. J Biol. Chem, 247, 3170-3175
Mitsuhashi, H., Ikeuchi, H., Nojima, Y. (2001) Is sulfite an antiatherogenic compound in wine?. Clinical chemistry, 47(10): 1872-3
Nguyen, M., Revel, M., Dougados, M. (1997) Prolonged effects of 3 week therapy in a spa resort on lumbar spine, knee and hip osteoarthritis: Follow-up after 6 months: A randomized controlled trial. British journal of rheumatology, 36(1): 77-81
Nomura, T., Yamaoka, K. (1999) Low-dose gamma-ray irradiation reduces oxidative damage induced by CCl4 in mouse liver. Free radical biology & medicine, 27(11-12): 1324-33
Rhoades, R., Pflanzer, R. (1996) Human physiology. Philadelphia: Saunders College Publishing
Rizzo, R., Grandolfo, M., Godeas, C., Jones, K.W., Vittur, F. (1995) Calcium, sulfur, and zinc distribution in normal and arthritic articular equine cartilage: A synchrotron radiation-induced X-ray emission (SRIXE) study. Journal of experimental zoology, 273(1): 82-6
Scheidleder, B., Holzer, F., Marktl, W. (2000) Einfluss von schwefeltrinkkuren auf parameter des lipidstoffwechsels, den antioxidantiven status und die koncentration von peroxiden bei kurpatienten. Forschende Komplement??rmedizin und Klassische Naturheilkunde / Research in Complementary and Classical Natural Medicine, 7(2): 75
Squires, G.R., Okouneff, S., Ionescu, M., Poole, R.A. (2003) The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis and rheumatism, 48(5): 1261-70
Studer, R., Jaffurs, D., Stefanovic-Racic, M., Robbins, P.D., Evans, C.H. (1999) Nitric oxide in osteoarthritis. Osteoarthritis and Cartilage, 7(4): 377
Sukenik, S., Flusser, D., Abu-Shakra, M. (1999) The role of spa therapy in various rheumatic diseases. Rheum Dis Clin North Am, 25(4): 883-97
Sukenik, S. (1996) Balneotherapy for rheumatic diseases at the Dead Sea area. Isr J Med Sci, 32, str. 16-9
Tiku, M.L., Shah, R., Allison, G.T. (2000) Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. Journal of biological chemistry, 275(26): 20069-76
Tiku, M.L., Gupta, S., Deshmukh, D.R. (1999) Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants. Free radical research, 30(5): 395-405
Tishler, M., Rosenberg, O., Levy, O., Elias, I., Amit-Vazina, M. (2004) The effect of balneotherapy on osteoarthritis. Is an intermittent regimen effective?. European journal of internal medicine, 15(2): 93-96
Wigler, I., Elkayam, O., Paran, D., Yaron, M. (1995) Spa therapy for gonarthrosis: A prospective study. Rheumatology international, 15(2): 65-8
Yamaoka, K., Mitsunobu, F., Hanamoto, K., Shibuya, K., Mori, S., Tanizaki, Y., Sugita, K. (2004) Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy. Journal of radiation research, 45(1): 83-8
Young, I.S., Woodside, J.V. (2001) Antioxidants in health and disease. J Clin Pathol, 54(3): 176-86
Yudoh, K., Nguyen, T., Nakamura, H., Hongo-Masuko, K., Kato, T., Nishioka, K. (2005) Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: Oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis research & therapy, 7(2): R380-91
 

O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/VSP1007573J
objavljen u SCIndeksu: 04.08.2010.

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