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2012, vol. 46, br. 1, str. 43-54
Patofiziologija gojaznosti
aUniverzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča
bUniverzitet u Beogradu, Medicinski fakultet, KBC 'Zemun'
cUniverzitet u Novom Sadu, Medicinski fakultet, Katedra za internu medicinu
dUniverzitet u Beogradu, Medicinski fakultet, Institut za kardiovaskularne bolesti 'Dedinje'
Sažetak
Gojaznost se danas smatra bolešću savremenog društva i njena zastupljenost u svetu ima karakter epidemije. Istraživanja usmerena na razumevanje biologije adipocitne ćelije i adipoznog tkiva, značajno doprinose rasvetljavanju mnogih aspekata različitih metaboličkih poremećaja koji prate pojavu gojaznosti tj. prekomerenog prisustva adipoznog tkiva. Gojaznost je posledica dugotrajnog pozitivnog energetskog balansa, neprimerenog stilu života savremenog čoveka. Danas je utemeljena činjenica da je adipozno tkivo endokrini organ u kojem se sintetiše i eksprimira više od 60 različitih faktora - adipokina, sa snažnim uticajem na veliki broj metaboličkih procesa u organizmu. Adipokini mogu imati pro-inflamatorno ili anti-inflamatorno dejstvo. Mnogobrojna istraživanja jasno ukazuju na uzročnu vezu gojaznosti i hronične inflamacije slabog inteziteta, koja vodi razvoju poremećaja vezanih za prisustvo gojaznosti, naročito metaboličkih poremećaja koji znatno umanjuju kvalitet života. Svojom endokrinom funkcijom, adipocitne ćelije reflektuju metabolički status i prenose informaciju na druge organe, tkiva kao i centralni nervni sistem.
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O članku

jezik rada: srpski
vrsta rada: neklasifikovan
objavljen u SCIndeksu: 22.03.2013.