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Sindrom hroničnog zamora - zdravi, bolesni ili nešto između?
aUniverzitet u Beogradu, Medicinski fakultet, KBC 'Dr Dragiša Mišović'
bnema
cKlinički centar Srbije, Klinika za endokrinologiju dijabetes i bolesti metabolizma, Beograd
Ključne reči: sindrom hroničnog zamora; HPA osovina; kortizol; ACTH test; ITT
Sažetak
Sindrom hroničnog zamora predstavlja kompleksan poremećaj nejasne etiologije koji dovodi do pojave izraženog umora u trajanju dužem od šest meseci. Ovaj umor je drugačiji od uobičajenog - ne smanjuje se odmaranjem i praćen je redukcijom prethodnih psihofizičkih aktivnosti i određenim brojem nespecifičnih simptoma. Zbog nejasne etiologije ovog poremećaja, naučnici još uvek razmatraju da li je to zaista oboljenje ili ne. Većina stručnjaka prepoznaje ovaj sindrom i prihvata ga kao bolest ukoliko postoji nekoliko udruženih simptoma. U potrazi za etiologijom ovog oboljenja u istraživanjima je ispitivana i funkcija hipotalamo-hipofizno-nadbubrežne osovine kao najbitnije osovine u regulaciji odgovora na stres. U 19. veku neurolog George Miller Beard je po prvi put okarakterisao zamor, anksioznost, glavobolju, impotenciju, neuralgiju i depresiju pojmom 'neurastenija'. Nakon toga je saopšteno još nekoliko pojmova poput mijalgični encefalomijelitis, hronični Epstein-Barr virus sindrom, sindrom hronične mononukleoze, atipični poliomijelitis, epidemijski vaskulitis, postvirusni sindrom zamora, sindrom hroničnog neuroendokrinoimunskog poremećaja tako da je ovaj sindrom nazvan 'oboljenjem sa 1000 imena'. Prve informacije u literaturi o poremećaju hipotalamo-hipofizno-nadbubrežne osovine u sindromu hroničnog zamora pojavile su se počev od 1980. godine. Interesovanje za poremećaj hipotalamo-hipofizno-nadbubrežne osovine (HPA) osovine u ovom sindromu naglo je poraslo kada je Poteliakhoff 1981. prvi uočio snižene vrednosti kortizola u ovih pacijenata. U to vreme kriterijumi za sindrom hroničnog zamora (chronic fatigue syndrome - CFS) nisu bili jasni ali je ovo otkriće bilo bazično za dalja istraživanja HPA osovine u sklopu ovog sindroma.
Reference
Abelson, J.L., Curtis, G.C. (1996) Hypothalamic-pituitary-adrenal axis activity in panic disorder: 24-hour secretion of corticotropin and cortisol. Arch Gen Psychiatry, 53(4): 323-31
Allain, T.J., Bearn, J.A., Coskeran, P., Jones, J., Checkley, A., Butler, J., Wessely, S., Miell, J.P. (1997) Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGF-binding protein-1 in chronic fatigue syndrome. Biol Psychiatry, 41(5): 567-73
Barnett, R. (2005) Fatigue. Lancet, 366(9479): 21
Berwaerts, J., Moorkens, G., Abs, R. (1998) Secretion of growth hormone in patients with chronic fatigue syndrome. Growth Horm IGF Res, 8 Suppl B: 127-9
Cleare, A.J., Sookdeo, S.S., Jones, J., O.V., Miell, J.P. (2000) Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome. J Clin Endocrinol Metab, 85(4): 1433-9
Cleare, A.J., O.V., Miell, J.P. (2004) Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome. Psychoneuroendocrinology, 29(6): 724-32
Cleare, A.J., Blair, D., Chambers, S., Wessely, S. (2001) Urinary free cortisol in chronic fatigue syndrome. Am J Psychiatry, 158(4): 641-3
Cleare, A.J., Miell, J., Heap, E., Sookdeo, S., Young, L., Malhi, G.S., O'Keane, V. (2001) Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy. J Clin Endocrinol Metab, 86(8): 3545-54
Cleare, A.J., Wessely, S.C. (1996) Chronic fatigue syndrome: A stress disorder?. Br J Hosp Med, 55(9): 571-4
Cleare, A.J. (2003) The neuroendocrinology of chronic fatigue syndrome. Endocr Rev, 24(2): 236-52
Cleare, A.J. (2004) The HPA axis and the genesis of chronic fatigue syndrome. Trends Endocrinol Metab, 15(2): 55-9
Crofford, L.J., Young, E.A., Engleberg, C.N., Korszun, A., Brucksch, C.B., Mcclure, L.A., Brown, M.B., Demitrack, M.A. (2004) Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain Behav Immun, 18(4): 314-25
Demitrack, M.A., Dale, J.K., Straus, S.E., Laue, L., Listwak, S.J., Kruesi, M.J., Chrousos, G.P., Gold, P.W. (1991) Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome. J Clin Endocrinol Metab, 73(6): 1224-34
di Giorgio, A., Hudson, M., Jerjes, W., Cleare, A.J. (2005) 24-hour pituitary and adrenal hormone profiles in chronic fatigue syndrome. Psychosomatic Medicine, 67(3): 433
Dinan, T.G. (1994) Glucocorticoids and the genesis of depressive illness: A psychobiological model. Br J Psychiatry, 164(3): 365-71
Ebrecht, M., Buske-Kirschbaum, A., Hellhammer, D., Kern, S., Rohleder, N., Walker, B., Kirschbaum, C. (2000) Tissue specificity of glucocorticoid sensitivity in healthy adults. J Clin Endocrinol Metab, 85(10): 3733-9
Fukuda, K., Straus, S.E., Hickie, I., Sharpe, M.C., Dobbins, J.G., Komaroff, A. (1994) The chronic fatigue syndrome: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med, 121(12): 953-9
Gaab, J., Hüster, D., Peisen, R., Engert, V., Schad, T., Schürmeyer, T.H., Ehlert, U. (2002) Low-dose dexamethasone suppression test in chronic fatigue syndrome and health. Psychosom Med, 64(2): 311-8
Giovannoni, G. (2006) Multiple sclerosis related fatigue. Journal of Neurology Neurosurgery & Psychiatry, 77(1): 2
Gold, P.W., Licinio, J., Wong, M.L., Chrousos, G.P. (1995) Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. Ann N Y Acad Sci, 771: 716-29
Hamilos, D.L., Nutter, D., Gershtenson, J., Redmond, D.P., Clementi, J.D., Schmaling, K.B., Make, B.J., Jones, J.F. (1998) Core body temperature is normal in chronic fatigue syndrome. Biol Psychiatry, 43(4): 293-302
Heim, C., Ehlert, U., Hellhammer, D.H. (2000) The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25(1): 1-35
Hunt, G.E., O.B.T., Johnson, G.F., Caterson, I.D. (1991) Effect of high plasma dexamethasone levels on DST sensitivity: Dose-response study in depressed patients and controls. Psychiatry Res, 36(2): 209-22
Kirschbaum, C., Kudielka, B.M., Gaab, J., Schommer, N.C., Hellhammer, D.H. (1999) Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med, 61(2): 154-62
Kuratsune, H., Yamaguti, K., Sawada, M., Kodate, S., Machii, T., Kanakura, Y., Kitani, T. (1998) Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med, 1(1): 143-6
Moorkens, G., Berwaerts, J., Wynants, H., Abs, R. (2000) Characterization of pituitary function with emphasis on GH secretion in the chronic fatigue syndrome. Clin Endocrinol (Oxf), 53(1): 99-106
Ottenweller, J.E., Sisto, S.A., Mccarty, R.C., Natelson, B.H. (2001) Hormonal responses to exercise in chronic fatigue syndrome. Neuropsychobiology, 43(1): 34-41
Parker, A.J., Wessely, S., Cleare, A.J. (2001) The neuroendocrinology of chronic fatigue syndrome and fibromyalgia. Psychol Med, 31(8): 1331-45
Poteliakhoff, A. (1981) Adrenocortical activity and some clinical findings in acute and chronic fatigue. J Psychosom Res, 25(2): 91-5
Pruessner, J.C., Wolf, O.T., Hellhammer, D.H., Buske-Kirschbaum, A., von Auer, K., Jobst, S., Kaspers, F., Kirschbaum, C. (1997) Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci, 61(26): 2539-49
Salata, R.A., Jarrett, D.B., Verbalis, J.G., Robinson, A.G. (1988) Vasopressin stimulation of adrenocorticotropin hormone (ACTH) in humans. In vivo bioassay of corticotropin-releasing factor (CRF) which provides evidence for CRF mediation of the diurnal rhythm of ACTH. J Clin Invest, 81(3): 766-74
Scott, L.V., Medbak, S., Dinan, T.G. (1999) Desmopressin augments pituitary-adrenal responsivity to corticotropin-releasing hormone in subjects with chronic fatigue syndrome and in healthy volunteers. Biol Psychiatry, 45(11): 1447-54
Scott, L.V., Medbak, S., Dinan, T.G. (1998) Blunted adrenocorticotropin and cortisol responses to corticotropin-releasing hormone stimulation in chronic fatigue syndrome. Acta Psychiatr Scand, 97(6): 450-7
Wallymahmed, M.E., Foy, P., Macfarlane, I.A. (1999) The quality of life of adults with growth hormone deficiency: comparison with diabetic patients and control subjects. Clin Endocrinol (Oxf), 51(3): 333-8
Wessely, S. (1993) The neuropsychiatry of chronic fatigue syndrome. Ciba Found Symp, 173: 212-29; discussion 229-37
Žarković, M.P., Pavlović, M., Pokrajac-Simeunović, A., Ćirić, J.D., Beleslin, B., Penezić, Z., Ognjanović, S., Savić, S., Poluga, J., Trbojević, B.J., Drezgić, M. (2003) Poremećaj funkcije nadbubrega u sindromu hroničnog zamora. Srpski arhiv za celokupno lekarstvo, vol. 131, br. 9-10, str. 370-374
 

O članku

jezik rada: srpski, engleski
vrsta rada: neklasifikovan
objavljen u SCIndeksu: 27.02.2009.

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