C-reactive protein in estimating inflammatory status in patients with acute coronary syndrome

Dimitrijević, Olivera; Đorić, Stojčevski Blagica; Ignjatović, Svetlana; Majkić, Singh Nada

doi:10.2478/v10011-007-0045-1

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Journal of Medical Biochemistry

2008, vol. 27, iss. 1, pp. 35-39

C-reactive protein in estimating inflammatory status in patients with acute coronary syndrome

Dimitrijević Olivera^a, Đorić Stojčevski Blagica^b, Ignjatović Svetlana^c

, Majkić Singh Nada^c

^aDepartment of Biochemistry, Health Center, Bor

^bDepartment of Internal Medicine, Health Center, Bor

^cClinical Center of Serbia, Center for Medical Biochemistry, Belgrade, Serbia

email: [email protected]

Keywords: acute coronary syndrome; acute myocardial infarction; C-reactive protein; inflammation; unstable anginapectoris

Abstract

Chronic inflammation plays a key role in the pathogenesis of atherosclerosis, and is considered as a risk factor for the occurrence of acute coronary events, together with traditional risk factors such as age, smoking, hypercholesterolemia, diabetes mellitus and genetic predisposition. In this study, inflammatory status was estimated in patients with acute coronary syndrome. C-reactive protein, erythrocyte sedimentation rate and white blood cell count were measured at admission to the hospital in 25 patients with unstable angina pectoris and 31 patients with acute myocardial infarction, and compared with healthy control group (n = 59). C-reactive protein was the only parameter that differed significantly between all three groups (p < 0.0001), and patients with unstable angina had higher levels (median 7.28 mg/L) than patients with myocardial infarction (4.10 mg/L) and control group (1.07 mg/L). The obtained results show that levels of chronic inflammation in patients with acute coronary syndrome are significantly higher than baseline inflammation levels in a healthy population.

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