Metrics

  • citations in SCIndeks: [1]
  • citations in CrossRef:[4]
  • citations in Google Scholar:[]
  • visits in previous 30 days:5
  • full-text downloads in 30 days:0

Contents

article: 1 from 1  
2012, vol. 31, iss. 1, pp. 60-64
Thrombocyte and erythrocyte indices in sepsis and disseminated intravascular coagulation
Faculty of Medicine, Zonguldak Karaelmas University, Turkey

email[email protected]
Keywords: sepsis; disseminated intravascular coagulation; platelet (thrombocyte) count; platelet (thrombocyte) indices; erythrocyte indices
Abstract
Sepsis is the inflammatory response against infection. The existence of DIC during sepsis indicates a poor prognosis and coagulation abnormalities and thrombocytopenia may exist. The aim of this study was to investigate platelet and erythrocyte indices in sepsis patients with DIC and without DIC. In both groups coagulation tests, platelet count and indices, erythrocyte count and indices were retrospectively analyzed. In the sepsis plus DIC patients the prothrombin time and D-dimer values were found significantly higher and fibrinogen, platelet and plateletcrit were found significantly lower than in the sepsis without DIC group. The analysis of mean platelet volume, platelet distribution width, erythrocyte count and indices revealed no significant differences between the two groups. These results showed us that the depression of bone marrow in septic patients with DIC and without DIC did not differ. The activation of the coagulation system might probably be the cause of thrombocyte depletion in DIC.
References
Akarsu, S., Taskin, E., Kilic, M., Ozdiller, S., Gurgoze, M.K., Yilmaz, E., Aygun, D.A. (2005) The effects of different infectious organisms on platelet counts and platelet indices in neonates with sepsis: Is there an organism-specific response?. Journal of tropical pediatrics, 51(6): 388-91
Akca, S., Haji-Michael, P., de Mendonça, A., Suter, P., Levi, M., Vincent, J.L. (2002) Time course of platelet counts in critically ill patients. Critical care medicine, 30(4): 753-6
Antović, J.P. (2010) 'Point-of-care' D-dimer testing. Journal of Medical Biochemistry, vol. 29, br. 4, str. 282-287
Bernard, G.R., Vincent, J.L., Laterre, P.F., LaRosa, S.P., Dhainaut, J.F., Lopez-Rodriguez, A., Steingrub, J.S., Garber, G.E., Helterbrand, J.D., Ely, E.W., Fisher, C.J. (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. New England journal of medicine, 344(10): 699-709
Brun-Buisson, C., Doyon, F., Carlet, J., Dellamonica, P., Gouin, F., Lepoutre, A., Mercier, J.C., Offenstadt, G., Regnier, B. (1995) Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA, 274(12): 968-74
Carey, M.J., Rodgers, G.M. (1998) Disseminated intravascular coagulation: Clinical and laboratory aspects. American Journal of Hematology, 59(1): 65-73
Creasey, A.A., Chang, A.C., Feigen, L., Wun, T.C., Taylor, F.B., Hinshaw, L.B. (1993) Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock. J Clin Invest, 91(6): 2850-60
Esper, R.C., Domínguez, V.C., Cordova, L., Cordova, J.R.C. (2008) Red blood cell distribution width changes in septic patients. Rev Assoc Mex Med Crit y Ter Int, 22 (1); 20-5
Franchini, M., Lippi, G., Manzato, F. (2006) Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation. Thrombosis journal, 4: 4
Kikuchi, M., Inagaki, T., Nitta, M., Imaida, K., Shinagawa, N., Banno, S., Komatsu, H., Wakita, A., Ueda, R. (1996) Changes in erythrocyte structure and in platelets in elderly patients with disseminated intravascular coagulation. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 33(11): 847-51
Kim, H.K., Kim, J.E., Ham, C.K., Lee, D.S., Park, S., Cho, H.I. (2008) Prognostic value of platelet indices as determined by ADVIA 120 in patients suspected of having disseminated intravascular coagulation. International journal of laboratory hematology, 30(2): 117-23
Kitchens, C.S. (2009) Thrombocytopenia and thrombosis in disseminated intravascular coagulation (DIC). Hematology, 2009(1): 240-246
Kunishima, S., Kobayashi, S., Naoe, T. (1996) Increased but highly dispersed levels of plasma glycocalicin in patients with disseminated intravascular coagulation. European journal of haematology, 56(3): 173-7
Levi, M., Toh, C.H., Thachil, J., Watson, H.G. (2009) Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Journal of Haematology, 145(1): 24-33
Levi, M., de Jonge, E., Meijers, J. (2002) The diagnosis of disseminated intravascular coagulation. Blood reviews, 16(4): 217-23
Levi, M., de Jonge, E., van der Poll, T. (2003) Sepsis and disseminated intravascular coagulation. Journal of thrombosis and thrombolysis, 16(1-2): 43-7
Levy, M.M., Fink, M.P., Marshall, J.C., Abraham, E., Angus, D., Cook, D., Cohen, J., Opal, S.M., Vincent, J., Ramsay, G., International Sepsis Definitions Conference (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med, 29(4): 530-8
Lundahl, T.H., Petersson, J., Fagerberg, I.H., Berg, S., Lindahl, T.L. (1998) Impaired platelet function correlates with multi-organ dysfunction. A study of patients with sepsis. Platelets, 9(3-4): 223-5
Lundahl, T.H., Lindahl, T.L., Fagerberg, I.H., Egberg, N., Bunescu, A., Larsson, A. (1996) Activated platelets and impaired platelet function in intensive care patients analyzed by flow cytometry. Blood coagulation & fibrinolysis, 7(2): 218-20
Peters, K., Unger, R.E., Brunner, J., Kirkpatrick, C.J. (2003) Molecular basis of endothelial dysfunction in sepsis. Cardiovascular Research, 60(1): 49-57
Sprung, C.L., Peduzzi, P.N., Shatney, C.H., Schein, R.M.H., Wilson, M.F., Sheagren, J.N., Hinshaw, L.B. (1990) Impact of encephalopathy on mortality in the sepsis syndrome. Critical Care Medicine, 18(8): 801-806
Taylor, F.B., Toh, C.H., Hoots, W.K., Wada, H., Levi, M. (2001) Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thrombosis and haemostasis, 86(5): 1327-30
Vanderschueren, S., de Weerdt, A., Malbrain, M., Vankersschaever, D., Frans, E., Wilmer, A., Bobbaers, H. (2000) Thrombocytopenia and prognosis in intensive care. Critical care medicine, 28(6): 1871-6
Yaguchi, A., Lobo, F.L.M., Vincent, J.L., Pradier, O. (2004) Platelet function in sepsis. Journal of thrombosis and haemostasis, 2(12): 2096-102
Yilmaz, Z., Eralp, O., Ilcol, Y.O. (2008) Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia. Veterinary clinical pathology, 37(2): 159-63
Yu, M., Nardella, A., Pechet, L. (2000) Screening tests of disseminated intravascular coagulation: Guidelines for rapid and specific laboratory diagnosis. Critical care medicine, 28(6): 1777-80
 

About

article language: English
document type: Original Scientific Paper
DOI: 10.2478/v10011-011-0043-1
published in SCIndeks: 22/03/2013

Related records

Anestezija i inten terapija (2005)
Hemostasys system disorders in acute pankreatitis
Radenković Dejan, et al.

Sanamed (2014)
Sepsis biomarkers and pathogen detection methods: State of the art
Schmitz Roland P.H., et al.

Vojnosanitetski pregled (2006)
Characteristics of immune response in urosepsis
Jevđić Jasna, et al.

show all [11]

Sustainable Development Goals (SDG)

Top SDG Classifications

  • No Poverty (58%)

  • Good Health and Well-being (25%)

  • Partnerships for the Goals (7%)

Goals Description