Metrics

  • citations in SCIndeks: [1]
  • citations in CrossRef:[5]
  • citations in Google Scholar:[]
  • visits in previous 30 days:9
  • full-text downloads in 30 days:0

Contents

article: 1 from 1  
Journal of Medical Biochemistry
2012, vol. 31, iss. 2, pp. 115-120
Oxidative stress in type 2 diabetes with iron deficiency in Asian Indians
Ganesh Swaminathana, Dharmalingam Malaa, Marcus Rani Sarab
aM.S. Ramaiah Medical College, Bangalore, India
bMSU-GEF International Medical School, Bangalore, India
Abstract
A close relationship exists between iron metabolism, diabetes and oxidative stress. Both diabetes and redox active iron are individually known to enhance oxidative stress. However, the role of iron deficiency and oxidative stress in diabetes is not clear; hence, the levels of oxidative stress in type 2 diabetes with and without iron deficiency have been compared. Two groups of 30 patients each with diabetes were selected (one group with iron deficiency and the other group with normal iron levels) and compared with 30 normal healthy controls. The anthropometric parameters, fasting blood sugar, iron profile and oxidative stress parameters (malondialdehyde levels (index of lipid peroxidation) and serum uric acid levels (antioxidant)) were measured. While the diabetes group had significantly increased serum levels of ferritin (an acute phase reactant and antioxidant) in comparison with normal controls (P=0.040), the diabetic group with iron deficiency had decreased serum levels of iron (P =0.000), ferritin (P = 0.000) and uric acid (P =0.006) and increased levels of malondialdehyde (P = 0.000) in comparison with diabetics without iron deficiency. This study shows an increase in oxidative stress in the diabetic group with iron deficiency together with reduction in antioxidant levels could further promote prooxidant levels and inflammation and in turn result in the development of complications in this high-risk Asian Indian population.
References

Aslan, M., Horoz, M., Kocyigit, A., Ozgonül, S., Celik, H., Celik, M., Erel, O. (2006) Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia. Mutation research, 601(1-2): 144-9

Coghetto, B.A., Lauerman, L.L., Duarte, M.B.V., Manfredini, V., Peralba, M.C.R., Silveira, B.M. (2009) Oxidative stress in older patients with iron deficiency anaemia. journal of nutrition, health & aging, 13(8): 666-70

Cook, J.D., Lipschitz, D.A., Miles, L.E., Finch, C.A. (1974) Serum ferritin as a measure of iron stores in normal subjects. American journal of clinical nutrition, 27(7): 681-7

Culleton, B.F., Larson, M.G., Kannel, W.B., Levy, D. (1999) Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study. Annals of internal medicine, 131(1): 7-13

Fernández-Real, J.M., López-Bermejo, A., Ricart, W. (2002) Cross-talk between iron metabolism and diabetes. Diabetes, 51(8): 2348-54

Galaris, D., Pantopoulos, K. (2008) Oxidative stress and iron homeostasis: Mechanistic and health aspects. Critical reviews in clinical laboratory sciences, 45(1): 1-23

Gutteridge, J.M., Rowley, D.A., Halliwell, B. (1982) Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of 'catalytic' iron and anti-oxidant activity in extracellular fluids. Biochemical journal, 206(3): 605-9

Herbert, V., Shaw, S., Jayatilleke, E., Stopler-Kasdan, T. (1994) Most free-radical injury is iron-related: It is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin. Stem cells, 12(3): 289-303

Lee, K.S., Lee, A.L., Winters, T.J., Tam, E., Jaleel, M., Stenvinkel, P., Johnson, R.J. (2009) Low serum uric acid level is a risk factor for death in incident hemodialysis patients. American journal of nephrology, 29(2): 79-85

Mojiminiyi, O.A., Marouf, R., Abdella, N.A. (2008) Body iron stores in relation to the metabolic syndrome, glycemic control and complications in female patients with type 2 diabetes. Nutrition, metabolism, and cardiovascular diseases, 18(8): 559-66

Parasuram, M.K., Natesh, P.R., Mohan, D.M., Sabitha, N., Janakarajan, V.N., Balasubramanian, N. (2010) Role of oxidative stress and antioxidants in children with IDA. International Journal of Collaborative Research on Internal Medicine & Public Health, 2: 2-18

Park, K. (2009) Nutrition and health: Park's Textbook of preventive and social medicine. Jabalpur, India: Banarsidas Bhanot, pp. 539, 20th ed

1

Sevanian, A., Davies, K.J., Hochstein, P. (1991) Serum urate as an antioxidant for ascorbic acid. American journal of clinical nutrition, 54(6 Suppl): 1129S-1134S

Swaminathan, S., Fonseca, V.A., Alam, M.G., Shah, S.V. (2007) The role of iron in diabetes and its complications. Diabetes care, 30(7): 1926-33

1

Thomas, M.C., MacIsaac, R.J., Tsalamandris, C., Power, D., Jerums, G. (2003) Unrecognized anemia in patients with diabetes: A cross-sectional survey. Diabetes care, 26(4): 1164-9

1

Torti, F.M., Torti, S.V. (2002) Regulation of ferritin genes and protein. Blood, 99(10): 3505-16

Toxqui, L., de Piero, A., Courtois, V., Bastida, S., Sánchez-Muniz, F.J., Vaquero, M.P. (2010) Iron deficiency and overload. Implications in oxidative stress and cardiovascular health. Nutrición hospitalaria, 25(3): 350-65

Tuomainen, T.P., Nyyssönen, K., Salonen, R., Tervahauta, A., Korpela, H., Lakka, T., Kaplan, G.A., Salonen, J.T. (1997) Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1,013 eastern Finnish men. Diabetes care, 20(3): 426-8

1

van Campenhout, A., van Campenhout, C., Lagrou, A.R., Abrams, P., Moorkens, G., van Gaal, L., Manuel-y-Keenoy, B. (2006) Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status. Diabetes/metabolism research and reviews, 22(6): 444-54

Wilbur, K.M., Bernheim, F., Shapiro, O.W. (1943) The TBARS reagent as test for the oxidation of unsaturated fatty acids by various agents. Arch Biochem Biophys, 24: 305-313

1

World Health Organization (2006) Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation. Geneva

Yoo, J., Maeng, H., Sun, Y., Kim, Y., Park, D., Park, T.S., Lee, S.T., Choi, J. (2009) Oxidative status in iron-deficiency anemia. Journal of clinical laboratory analysis, 23(5): 319-23
   

About

article language: English
document type: Original Scientific Paper
DOI: 10.2478/v10011-011-0049-8
published in SCIndeks: 22/03/2013

Related records

Medicinski pregled (2007)
Anemia in patients with diabetes mellitus
Dimković Nada

Acta agriculturae Serbica (2013)
Impact of varieties and production methods on yield and content of vitamin C in winter lettuce produced in the greenhouse
Govedarica Lučić Aleksandra, et al.

Srps arh celokup lekarstvo (2012)
Influence of moderate physical activity on the levels of plasma lipoproteins in subjects with impaired glucose tolerance
Petković Košćal Milanka, et al.

show all [5]

Sustainable Development Goals (SDG)

Top SDG Classifications

  • Good Health and Well-being (74%)

  • Partnerships for the Goals (9%)

  • Quality Education (3%)

Goals Description