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Journal of Medical Biochemistry
2015, vol. 34, br. 2, str. 191-199
Korelacija između glikoliziranog hemoglobina i HOMA indeksa u dijabetes melitusu tipa 2 - predviđanje funkcije beta ćelija na osnovu glikoliziranog hemoglobina
Kadhem Al-Hakeim Husseina, Saied Abdulzahra Mohammedb
aKufa University, College of Science, Iraq
bKufa University, Dean of the College of Medicine, Iraq

e-adresa: headm2010@yahoo.com
Ključne reči: Benetov indeks; HbA1c; insulinska rezistencija; QUICKI; dijabetes melitus tip 2
Sažetak
Uvod: Cilj ove studije bio je da se odredi najefikasnija funkcija insulinske rezistencije u odnosu na glikemijsku kontrolu izraženu kroz glikolizirani hemoglobin (HbA1c) kod obolelih od dijabetes melitusa tipa 2 (T2DM). Drugi cilj bio je da se izvedu jednačine za predviđanje funkcije beta ćelija koje, pored glukoze natašte i insulina, kao parametar sadrže HbA1c. Metode: Pacijenti sa T2DM grupisani su prema sledećim obeležjima: (1) stepenu kontrole (dobra, zadovoljavajuća i slaba kontrola) i (2) insulinskoj rezistenciji utvrđenoj na osnovu dobijenih podataka i značajnih razlika između grupa otkrivenih pomoću procene modela homeostaze (HOMA) srodnih parametara (insulinske rezistencije - HOMA2IR, funkcije beta ćelija - HOMA%B i osetljivosti na insulin - HOMA%S). Korelacije i predikciona regresiona analiza su izračunate. Rezultati: Utvrđeno je da je HbA1c bio u korelaciji sa parametrima insulinske rezistencije u podgrupama sa T2DM. Ova korelacija takođe je značajno korelisana sa HOMA%B i indeksom QUICKI (kvantitativni indeks insulinske osetljivosti) u grupama sa zadovoljavajućom i slabom kontrolom. Regresiona analiza je upotrebljena za predviđanje predikcionih jednačina za HOMA%B. Najprimenljivije jednačine izvedene su za grupu zdravih kontrolnih subjekata (HOMA2%B =-1,76*FBG + 5,00*insulin+4,69*HbA1c+189,84) i grupu sa slabom kontrolom (HOM A2% B=0,001*FBG+0,5*insulin-8,67*HbA1c+101,96). Ove jednačine mogle su se upotrebiti za predviđanje funkcije beta ćelija (HOMA%B) pošto su dobijene vrednosti FBG, insulina i HbA1c za zdravu grupu i grupu sa slabom kontrolom. U grupama sa dobrom i zadovoljavajućom kontrolom pokušaj primene modela HOMA nije dao odgovarajuće rezultate. Zaključak: Funkcija beta ćelija koreliše sa QUICKI i HbA1c i može se pravilno odrediti na osnovu HbA1c, insulina i glukoze u zdravoj grupi i grupi sa slabom kontrolom. Ustanovljene su nove regresione jednačine koje uključuju HbA1c.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC4922324
DOI: 10.2478/jomb-2014-0033
objavljen u SCIndeksu: 03.01.2020.

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