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Journal of Medical Biochemistry
2015, vol. 34, br. 4, str. 409-413
Podložnost raku dojke i genetski Ins/Del polimorfizam u intronu 3 gena XRCC4 za reparaciju dvolančanih prekida DNK
Saadat Mostafaa, Saadat Shekoofehb
aShiraz University, College of Sciences, Department of Biology, Shiraz, Iran + Shiraz University, Institute of Biotechnology, Shiraz, Iran
bShiraz University, College of Sciences, Department of Biology, Shiraz, Iran

e-adresa: saadat@shirazu.ac.ir
Ključne reči: starost prilikom dijagnoze; kancer dojke; polimorfizam; podložnost; XRCC4
Sažetak
Uvod: Pošto su genetske varijacije u reparatornom genu Xray cross-complementing group 4 (XRCC4; OMIM: 194363) možda povezane sa smanjenjem ćelijskog kapaciteta za reparaciju DNK, postavljena je hipoteza da Ins/Del (I/D) polimorfizam XRCC4 (u intronu 3 tog gena; rs28360071) može biti faktor rizika za rak dojke. Iz tog razloga, sprovedeno je ovo ispitivanje. Metode: Ova anamnestička studija obuhvatila je 407 žena sa kancerom dojke i ukupno 394 zdrave žene iz opšte populacije uparene sa pacijentkinjama prema starosti. Genotipska analiza za I/D polimorfizam XRCC4 obavljena je pomoću PCR. Za istraživanje uticaja I/D polimorfizma XRCC4 na starost prilikom dijagnostikovanja kancera dojke korišćeni su Kaplan-Meierova analiza preživljavanja i Coxov regresioni model proporcionalnih rizika. Rezultati: Na osnovu ove anamnestičke studije, ID (OR = 0,95, 95% CI: 0,60-1,31, P = 0,781) i DD (OR = 1,24, 95% CI: 0,84-1,83, p = 0,274) genotipi nisu bili povezani sa rizikom od kancera dojke u poređenju sa II genotipom. Na osnovu Coxovog regresionog modela, postojala je značajna povezanost između genotipova I/D polimorfizma i starosti prilikom dijagnostikovanja kancera dojke (ID+DD vs II; HR = 0,79, 95% CI: 0,64-0,98, P = 0,036). Zaključak: Iako nije bilo značajne povezanosti između I/D polimorfizma XRCC4 i rizika od kancera dojke, pacijentkinje sa II genotipom imaju manje vrednosti za starost prilikom dijagnoze u poređenju s pacijentkinjama sa II + DD genotipovima.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC4922352
DOI: 10.2478/jomb-2014-0051
objavljen u SCIndeksu: 03.01.2020.

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