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2016, vol. 35, br. 3, str. 282-292
Povezanost kardiovaskularnog rizika sa tradicionalnim i netradicionalnim kardiometaboličkim parametrima kod gojaznih adolescentkinja
aPrimary Health Care Center, Podgorica, Montenegro
bUniverzitet u Beogradu, Medicinski fakultet, Institut za medicinsku statistiku i informatiku, Srbija
cKlinički centar Niš, Klinika za dečje interne bolesti, Srbija
dUniverzitet u Beogradu, Farmaceutski fakultet, Institut za medicinsku biohemiju, Srbija

e-adresajkotur@pharmacy.bg.ac.rs
Projekat:
Interaktivna uloga dislipidemije, oksidativnog stresa i inflamacije u aterosklerozi i drugim bolestima: genetički i biohemijski markeri (MPNTR - 175035)

Ključne reči: adolescenti; kardiovaskularni rizik; inflamacija; gojaznost; ukupni bilirubin
Sažetak
Uvod: Kako je skor kardiovaskularnog (KV) rizika često potcenjen kod dece i adolescenata, naročito u zemljama u razvoju, kakva je Crna Gora, gde postoji jaka interakcija između genetski uslovljenog KV rizika i sredine, cilj ove studije je bio da se proceni KV rizik kod zdravih adolescentkinja. Takođe, cilj je bio i da se ispitaju neki novi KV faktori rizika u interakciji sa tradicionalnim, kao što je gojaznost. Preciznije, imali smo za cilj da ispitamo uticaj niskih vrednosti bilirubina, rutinskog biohemijskog parametra, kao dodatnog faktora rizika za aterosklerozu u adultnom dobu. Metode: Ukupno 45 gojaznih adolescentkinja, srednje starosne dobi 17,8± 1,22 godina, i 45 normalno uhranjenih adolescentkinja, uparenih po godinama starosti, nepušača, uključeno je u studiju. Mereni su antropometrijski i biohemijski parametri. Skor kardiovaskularnog rizika (CVRS) računat je dodavanjem poena za svaki faktor rizika (pol, HDL-holesterol, non-HDL-holesterol, krvni pritisak i glikemija našte). Rezultati: Utvrđena je statistički značajna pozitivna povezanost između CVRS i ALT, hsCRP i TG/HDL-holesterola (P<0,001). Višestruka linearna regresiona analiza je pokazala da su veći obim struka i viši LDL-holesterol, a niži HDL-holesterol nezavisni prediktori nižih vrednosti bilirubina (R2 = 0,603, P<0,001). Zaključak: Gojazne adolescentkinje imaju povećan rizik za KV bolesti u kasnijem dobu. Pored tradicionalnih faktora rizika, ukupni bilirubin može imati potencijal da diskriminiše između niskog i većeg rizika za KV promene kod zdravih adolescentkinja.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC5346806
DOI: 10.1515/jomb-2016-0005
objavljen u SCIndeksu: 02.02.2020.

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