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Journal of Medical Biochemistry
2016, vol. 35, br. 3, str. 302-311
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 02/02/2020
PMC ID: PMC5346808
doi: 10.1515/jomb-2016-0009
Povezanost polimorfizma GSTO1 i GSTO2 sa rizikom od terminalne faze bubrežne insuficijencije I preživljavanjem bolesnika
aSerbian Chamber of Biochemists
bKlinički centar Srbije, Centar za medicinsku biohemiju, Beograd
cUniverzitet u Beogradu, Medicinski fakultet, Institut za epidemiologiju
dKliničko-bolnički centar Zvezdara, Beograd + Univerzitet u Beogradu, Medicinski fakultet
eUniverzitet u Beogradu, Medicinski fakultet, KBC 'Zemun'

e-adresa: tatjanasimic@med.bg.ac.rs

Sažetak

Uvod: Oksidativni stres je kod pacijenata sa terminalnom slabošću bubrega (TSB) povezan sa brojnim kardiovaskularnim komplikacijama. Pored uloge u detoksikaciji, citosolne glutation transferaze (GST) poseduju i antioksidantnu aktivnost. Članovi GST klase omega, GSTO 1 i GSTO2, katališu nekoliko reakcija koje nisu tipične za ostale GST, kao što su reakcija uklanjanja glutationa i dehidroaskorbat-reduktazna aktivnost. Cilj studije bio je da se ispita uloga polimorfizama gena GSTO1 (rs4925) i GSTO2 (rs156697) na razvoj terminalne bubrežne slabosti, kao i njihova uloga u preživljavanju ovih bolesnika. Metode: GSTO1 i GSTO2 genotipovi određivani su kod 199 bolesnika sa TSB i 199 kontrola uparenih po polu i starosti. Proteinske tiol i karbonilne grupe, kao markeri oksidativnog oštećenja proteina, određivane su spektrofotometrijski. Uticaj GSTO1 i GSTO2 genotipova na rizik za smrtni ishod analiziran je pomoću Cox regresione analize, a verovatnoća preživljavanja je analizirana pomoću Kaplan Meier metode tokom 36 meseci praćenja bolesnika. Rezultati: Osobe sa varijantnim GSTO2 GG genotipom su bile pod 2,45 puta većim rizikom za razvoj TSB u odnosu na bolesnike sa referentnim GSTO2 AA genotipom (OR = 2,45; 95%CI = 1 ,1 8 -5 ,0 7 ; p = 0 ,0 1 6 ). Rezultati GSTO1/GSTO2 haplotip analize pokazali su da haplotip kombinacija GSTO1 (*A)/ GSTO2 (*A) (GSTO1 varijantni/GSTO2 referentni alel) deluj'e protektivno na razvoj' TSB (O R = 0,23; 95% C I= 0,12-0,44; p= 0,001). Bolesnici koji su nosioci bar jednog GSTO1 referentnog alela imaju kraće ukupno (log rank=2,844; p= 0,241) i kardiovaskularno preživljavanje (log rank=4,211; p= 0,122). Zaključak: Polimorfizam gena za GSTO je povezan sa povećanim rizikom za razvoj terminalne slabosti bubrega kao i sa preživljavanjem ovih bolesnika.

Ključne reči

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