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2017, vol. 36, br. 1, str. 73-83
Analiza promena nivoa paratireoidnog hormona i 25 (OH) vitamina D u odnosu na starost, pol i godišnje doba - studija istraživanja podataka
aAcibadem University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey + Acibadem Healthcare Group, Clinlab Laboratories, Ankara, Turkey
bAcibadem University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey

e-adresamuhittin.serdar@acibadem.edu.tr
Sažetak
Uvod: 25 (OH) vitamin D3 (25(OH)D) i paratireoidni hormon (PTH) imaju važnu ulogu u regulisanju homeostaze kalcijuma. Cilj ove studije bio je da se retrospektivno odrede cut-off vrednosti za dovoljan nivo 25(OH)D u regionu sa četiri godišnja doba, kao i uticaj starosti, godišnjeg doba i pola na nivoe 25(OH)D i PTH u serumu. Metode: Laboratorijski rezultati 9890 žena i 2723 muškarca starosti 38,8±22,1 godina kod kojih su istovremeno mereni 25(OH)D i PTH retrospektivno su analizirani statističkim softverom. Nivoi 25(OH)D i PTH u serumu mereni su metodom masene spektrometrije, odnosno elektrohemiluminiscencije. Rezultati: Srednji nivoi 25(OH)D pokazali su sinusoidnu fluktuaciju tokom cele godine i bili su značajno viši (p<0,01) u leto i jesen. S druge strane, nivoi PTH bili su značajno viši (p<0,01) kod žena i pokazali su suprotan odgovor na sezonske efekte u odnosu na 25(OH)D. Najniži nivoi 25(OH)D otkriveni su kod ljudi starosti između 20 i 40 godina, dok su hormonski nivoi PTH sa starenjem bili u postepenom porastu. Značajan eksponencijalni obrnut odnos koji je utvrđen između PTH i 25(OH)D (PTH =exp(4,12-0,064* koren2 (25(O H)D)) (r= -0 ,3 2 5 , R-na kvadrat=0,105, p<0,001)) ukazao je na to da cut-off vrednost za dovoljan nivo 25(OH)D treba da bude 75 nmol/L. Zaključak: Naša retrospektivna studija zasnovana na velikim skupinama podataka potvrđuje da je trenutno prihvaćena klinička cut-off vrednost od 75 nmol/L prigodna za dovoljan nivo 25(OH)D. Međutim, utvrđivanje nedostatka vitamina D ostaje teško izvodljivo usled varijacija u serumskom nivou 25(OH)D zbog godišnjih doba. Stoga, merenje PTH trebalo bi da posluži kao komplement rezultatima 25(OH)D prilikom dijagnostikovanja nedostatka vitamina D. Najvažnije je da se u budućnosti razmotre različiti kriterijumi prilagođeni različitim godišnjim dobima.
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O članku

jezik rada: engleski
vrsta rada: izvorni članak
PMC ID: PMC5471662
DOI: 10.1515/jomb-2017-0002
objavljen u SCIndeksu: 23.01.2020.