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Journal of Medical Biochemistry
2017, vol. 36, br. 1, str. 73-83
Analiza promena nivoa paratireoidnog hormona i 25 (OH) vitamina D u odnosu na starost, pol i godišnje doba - studija istraživanja podataka
Serdar Muhittin A.a, Batu Can Başarb, Kilercik Meltemb, Durer Zeynep A.b, Benli Aksungar Fehimeb, Serteser Mustafab, Coskun Abdurrahmanb, Ozpinar Ayselb, Unsal Ibrahimb
aAcibadem University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey + Acibadem Healthcare Group, Clinlab Laboratories, Ankara, Turkey
bAcibadem University, School of Medicine, Department of Medical Biochemistry, Istanbul, Turkey

e-adresa: muhittin.serdar@acibadem.edu.tr
Sažetak
Uvod: 25 (OH) vitamin D3 (25(OH)D) i paratireoidni hormon (PTH) imaju važnu ulogu u regulisanju homeostaze kalcijuma. Cilj ove studije bio je da se retrospektivno odrede cut-off vrednosti za dovoljan nivo 25(OH)D u regionu sa četiri godišnja doba, kao i uticaj starosti, godišnjeg doba i pola na nivoe 25(OH)D i PTH u serumu. Metode: Laboratorijski rezultati 9890 žena i 2723 muškarca starosti 38,8±22,1 godina kod kojih su istovremeno mereni 25(OH)D i PTH retrospektivno su analizirani statističkim softverom. Nivoi 25(OH)D i PTH u serumu mereni su metodom masene spektrometrije, odnosno elektrohemiluminiscencije. Rezultati: Srednji nivoi 25(OH)D pokazali su sinusoidnu fluktuaciju tokom cele godine i bili su značajno viši (p<0,01) u leto i jesen. S druge strane, nivoi PTH bili su značajno viši (p<0,01) kod žena i pokazali su suprotan odgovor na sezonske efekte u odnosu na 25(OH)D. Najniži nivoi 25(OH)D otkriveni su kod ljudi starosti između 20 i 40 godina, dok su hormonski nivoi PTH sa starenjem bili u postepenom porastu. Značajan eksponencijalni obrnut odnos koji je utvrđen između PTH i 25(OH)D (PTH =exp(4,12-0,064* koren2 (25(O H)D)) (r= -0 ,3 2 5 , R-na kvadrat=0,105, p<0,001)) ukazao je na to da cut-off vrednost za dovoljan nivo 25(OH)D treba da bude 75 nmol/L. Zaključak: Naša retrospektivna studija zasnovana na velikim skupinama podataka potvrđuje da je trenutno prihvaćena klinička cut-off vrednost od 75 nmol/L prigodna za dovoljan nivo 25(OH)D. Međutim, utvrđivanje nedostatka vitamina D ostaje teško izvodljivo usled varijacija u serumskom nivou 25(OH)D zbog godišnjih doba. Stoga, merenje PTH trebalo bi da posluži kao komplement rezultatima 25(OH)D prilikom dijagnostikovanja nedostatka vitamina D. Najvažnije je da se u budućnosti razmotre različiti kriterijumi prilagođeni različitim godišnjim dobima.
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O članku

jezik rada: engleski
vrsta rada: izvorni članak
PMC ID: PMC5471662
DOI: 10.1515/jomb-2017-0002
objavljen u SCIndeksu: 23.01.2020.

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