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2018, vol. 37, br. 1, str. 21-30
Novi marker za prognozu akutnog pankreatitisa - kombinacija PLR i NLR
aTurkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, Turkey
bAnkara Numune Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey

e-adresamustafakaplandr@yahoo.com
Ključne reči: Atlanta klasifikacija; BISAP skor; nekrotizirajuci pankreatitis; Ranson skor
Sažetak
Uvod: Svrha ovog istraživanja je da se utvrdi značajnost kombinacije trombocitno-limfocitnog odnosa (PLR) i neutrofilnolimfocitnog odnosa (NLR) za dijagnostikovanje aktunog pankreatitisa kao i u odnosu na mortalitet. Metode: Retrospektivno izučavanje obuhvatilo je 142 pacijenta sa dijagnozom akutnog pankreatitisa. Ranson, Atlanta i BISAP 0h, 24h i 48h skorovi kod pacijenata računati su uvidom u istorije bolesti pacijenata. Pacijenti su podeljeni u tri grupe i to niskog, srednjeg i visokog rizika prema nivoima njihovih PLR i NLR. Rezultati: Broj pacijenata sa akutnim pankreasnim komplikacijama kao sto su nekrotizirajuci pankreatitis, akutni renalni poremecaj, sepsa i holangitis bili su značajno visi u grupi sa visokim rizikom u odnosu na druge grupe. Nađeno je da je kod visoko rizične grupe mortalitet iznosio 90%, 16% kod grupe sa srednjim rizikom i 1,9% kod grupe niskog rizika. Broj pacijenata sa Ranson skorom 5 i 6, teskim Atlanta skorom, i BISAP 0h skorom 3 i 4, i BISAP 24h i 48h skorom 4 i 5 je bio visi u grupi sa visokim rizikom u odnosu na druge grupe. Utvrđeno je da su PLR-NLR kombinacija, Atlanta i Ranson skorovi, i nivo C-reaktivnog proteina bili nezavisni faktori rizika u predviđanju mortalitea u regresionom modelu. PLR-NLR kombinacija je imala najvecu povrsinu ispod vrednosti krive u predviđanju prognoze akutnog pankreatitisa i sličnu dijagnostičku diskriminaciju sa drugim skor sistemima. Zaključak: U našem izučavanju nađeno je da PLR-NLR kombinacija ima sličan prognostički značaj sa drugim skor sistemima koji se koriste za utvrđivanje prognoze akutnog pankreatitisa.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC6294107
DOI: 10.1515/jomb-2017-0039
objavljen u SCIndeksu: 14.02.2020.