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Journal of Medical Biochemistry
2019, vol. 38, br. 3, str. 268-275
Povezanosti plazmatskog katepsina S sa holesterolom lipoproteina visoke gustine i bilirubinom kod pacijenata sa aneurizmom abdominalne aorte
Mirjanić-Azarić Bosaa, Vasić Novakb, Cerne Darkoc, Koš Jankod, Bogavac-Stanojević Natašae ORCID
aKlinički centar Republike Srpske, Banja Luka, Republika Srpska, BiH + Univerzitet u Banjoj Luci, Medicinski fakultet, Republika Srpska, BiH
bKlinički centar Republike Srpske, Služba za vaskularnu hirurgiju, Banja Luka, Republika Srpska, BiH
cUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
dUniversity of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia + Jožef Stefan Institute, Department of Biochemistry and Molecular Biology, Ljubljana, Slovenia
eUniverzitet u Beogradu, Farmaceutski fakultet, Institut za medicinsku biohemiju

e-adresa: bodamirjanic@blic.net
Sažetak
Uvod: Katepsin S (CTSS) je cisteinska proteaza uključena u aterogenezu. Uporedili smo plazmatski CTSS kao i druge biomarkere ateroskleroze kod pacijenata sa aneurizmom abdominalne aorte (AAA) i aorto ilijačnom okluzivnom bolešću (AOD) sa ciljem da se identifikuju osnovni patogeni mehanizmi razvoja bolesti. Takođe, pretpostavili smo da se nivo plazmatskog CTSS istovremeno povećava sa smanjenjem vrednosti holesterola plazmatskih lipoproteina visoke gustine (HDL-C). Metode: Ova studija je obuhvatila 33 pacijenta sa AAA i 34 pacijenta sa AOD. Rezultati: Nije bilo razlike u nivou plazmatskog CTSS između dve analizirane grupe (p = 0,833). Kod pacijenata sa AAA, plazmatski CTSS je bio u korelaciji sa HDL-C (r = -0,377, p = 0,034) i ukupnim bilirubinom (r = - 0,500, p = 0,003), dok, neočekivano, nije bio u korelaciji sa cistatinom C (Cys C) (r = 0,083, p = 0,652). Kod pacijenata sa AOD, plazmatski CTSS je bio u korelaciji sa trigliceridima (r = 0,597 p < 0.001). Kada su pacijenti podeljeni prema HDL-C (sa HDL-C < 0,90 i HDL-C > 0,90 mmol/L), vrednosti plazmatskog CTSS su se razlikovale među grupama (31,27 naspram 25,61 mg/L, respektivno, p < 0,001). Zaključak: Ovi rezultati pružaju prvi dokaz da je CTSS negativno povezan sa HDL-C i bilirubinom kod pacijenata sa AAA. Pretpostavka je da se na osnovu razlike u aso - cijaciji CTSS-a i drugih markera ateroskleroze može utvrditi da li CE ateroskleroza aorte dovesti do dilatacije ili stenoze.
Reference

Abisi, S., Burnand, K.G., Waltham, M., Humphries, J., Taylor, P.R., Smith, A. (2007) Cysteine protease activity in the wall of abdominal aortic aneurysms. Journal of Vascular Surgery, 46(6): 1260-1266

1

Baranano, D.E., Rao, M., Ferris, C.D., Snyder, S.H. (2002) Biliverdin reductase: A major physiologic cytoprotectant. Proceedings of the National Academy of Sciences, 99(25): 16093-16098

Burillo, E., Lindholt, J.S., Molina-Sanchez, P.I., Martinezpinna, R., Blanco-Colio, L.M. (2015) ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression. Thromb Haemost, 113: 1335-46

Cheng, X.W., Murohara, T., Kuzuya, M., Izawa, H., Sasaki, T., Obata, K., et al. (2008) Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodelling and represents a target for angiotensin II type 1 receptor blocker treatment. American Journal of Pathology, 173(2): 358-369

Clair, D.G., Beach, J.M. (2015) Strategies for managing aortoiliac occlusions: Access, treatment and outcomes. Expert Review of Cardiovascular Therapy, 13(5): 551-563

Delbosc, S., Diallo, D., Dejouvencel, T., Lamiral, Z., Louedec, L., Martin-Ventura, J.L., Rossignol, P., Leseche, G., Michel, J., Meilhac, O. (2013) Impaired high-density lipoprotein anti-oxidant capacity in human abdominal aortic aneurysm. Cardiovascular Research, 100(2): 307-315

Djoussé, L., Levy, D., Cupples, L. A., Evans, J.C., D'agostino, R.B., Ellison, R. (2001) Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. American Journal of Cardiology, 87(10): 1196-1200

Figueiredo, J.L., Aikawa, M., Zheng, C., Aaron, J., Lax, L., Libby, P., de Lima, F.J.L., Gruener, S., Fingerle, J., Haap, W., Hartmann, G., Aikawa, E. (2015) Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice with Chronic Renal Disease. American Journal of Pathology, 185(4): 1156-1166

Golledge, J., Norman, P. (2010) Atherosclerosis and abdominal aortic aneurysm: Cause, response or common risk factors?. Arterioscler Thromb Vasc Biol, 30: 10-75

Jormsjö, S., Wuttge, D.M., Sirsjö, A., Whatling, C., Hamsten, A., Stemme, S., Eriksson, P. (2002) Differential Expression of Cysteine and Aspartic Proteases during Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice. American Journal of Pathology, 161(3): 939-945

Karathanasis, S.K., Freeman, L.A., Gordon, S.M., Remaley, A.T. (2017) The Changing Face of HDL and the Best Way to Measure It. Clinical Chemistry, 63(1): 196-210

Kontush, A., Lhomme, M. (2015) Lipidomics of Plasma High-Density Lipoprotein: Insights into Anti-Atherogenic Function. Journal of Glycomics & Lipidomics, 05(03): 3-6

Kos, J., Sekirnik, A., Kopitar, G., Cimerman, N., Kayser, K., Stremmer, A., Fiehn, W., Werle, B. (2001) Cathepsin S in tumours, regional lymph nodes and sera of patients with lung cancer: Relation to prognosis. British Journal of Cancer, 85(8): 1193-1200

Lindholt, J.S., Erlandsen, E.J., Henneberg, E.W. (2001) Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms. British Journal of Surgery, 88(11): 1472-1475

Lindstedt, L., Lee, M., Öörni, K., Brömme, D., Kovanen, P.T. (2003) Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells. Biochemical and Biophysical Research Communications, 312(4): 1019-1024

Liu, J., Sukhova, G.K., Sun, J.S., Xu, W.H., Libby, P., Shi, G.P. (2004) Lysosomal Cysteine Proteases in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(8): 359-66

1

Lutgens, S.P., Cleutjens, K.B., Daemen, M.J., Heeneman, S. (2007) Cathepsin cysteine proteases in cardiovascular disease. FASEB J, 21: 3029-41

Lv, B.J., Lindholt, J.S., Cheng, X., Wang, J., Shi, G. (2012) Plasma Cathepsin S and Cystatin C Levels and Risk of Abdominal Aortic Aneurysm: A Randomized Population-Based Study. PLoS One, 7(7): e41813-e41813

1

Marković, D., Jevtović-Stoimenov, T., Ćosić, V.S., Stošić, B., Dinić, V., Marković-Živković, B., Janković, R.J. (2018) Clinical utility of survivin (BIRC5), novel cardiac biomarker, as a prognostic tool compared to high-sensitivity C-reactive protein, heart-type fatty acid binding protein and revised Lee score in elderly patients scheduled for major non-cardiac surge. Journal of Medical Biochemistry, vol. 37, br. 2, str. 110-120

Mirjanić-Azarić, B., Vekić, J., Željković, A., Jelić-Ivanović, Z., Đeric, M., Milivojac, T., Pecar-Fonović, U., Marc, J., Koš, J., Cerne, D. (2014) Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. Journal of Atherosclerosis and Thrombosis, 21(8): 868-877

2

Novotný, L., Vítek, L. (2003) Inverse Relationship Between Serum Bilirubin and Atherosclerosis in Men: A Meta-Analysis of Published Studies. Experimental Biology and Medicine, 228(5): 568-571

1

Oda, E. (2015) Cross-sectional and longitudinal associations between serum bilirubin and dyslipidemia in a health screening population. Atherosclerosis, 239: 31-7

Peshkova, I.O., Schaefer, G., Koltsova, E.K. (2016) Atherosclerosis and aortic aneurysm: Is inflammation a common denominator?. FEBS Journal, 283(9): 1636-1652

Qin, Y., Yang, Y., Liu, R., Cao, X., Liu, O., Liu, J., Wang, M., Yang, Y., Chen, Z., Zhang, H., Du, J. (2013) Combined Cathepsin S and hs-CRP predicting inflammation of Abdominal Aortic Aneurysm. Clinical Biochemistry, 46(12): 1026-1029

Qin, Y., Cao, X., Guo, J., Zhang, Y., Pan, L., Zhang, H., Li, H., Tang, C., Du, J., Shi, G. (2012) Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovascular Research, 96(3): 401-410

Qin, Y., Ye, P., He, J., Sheng, L.Q., Wang, L., Du, J. (2010) Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a 'Western-style diet' by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels. Acta Pharmacologica Sinica, 31(10): 1350-1358

Rye, K.-A. (2013) High density lipoprotein structure, function, and metabolism: A new Thematic Series. Journal of Lipid Research, 54(8): 2031-2033

Spielmann, N., Mutch, D.M., Rousseau, F., Tores, F., Hager, J., Bertrais, S., Basdevant, A., Tounian, P., Dubern, B., Galan, P., Clément, K. (2008) Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations. Clinical Genetics, 74(2): 155-163

Sukhova, G.K., Shi, G.P., Simon, D.I., Chapman, H.A., Libby, P. (1998) Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. Journal of Clinical Investigation, 102(3): 576-583

Taleb, S., Cancello, R., Clément, K., Lacasa, D. (2006) Cathepsin S Promotes Human Preadipocyte Differentiation: Possible Involvement of Fibronectin Degradation. Endocrinology, 147(10): 4950-4959

1

Telo, S., Kuluoztürk, M., Deveci, F., Kirkil, G., Öner, Ö., Kaman, D. (2018) Serum cystatin C levels in COPD: Potential diagnostic value and relation between respiratory functions. Journal of Medical Biochemistry, vol. 37, br. 4, str. 434-440

1

Vitek, L., Jirsa, M., Brodanova, M., Kalab, M., Marecek, Z., Danzig, V., et al. (2002) Gilbert syndrome and ischemic heart disease: A protective effect of elevated bilirubin levels. Atherosclerosis, 160: 449-56

Wilkinson, R.D.A., Williams, R., Scott, C.J., Burden, R.E. (2015) Cathepsin S: Therapeutic, diagnostic, and prognostic potential. Biological Chemistry, 396(8): 867-882