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Journal of Medical Biochemistry
2019, vol. 38, br. 4, str. 503-511
Serumski biomarkeri kod pacijenata sa stabilnim i akutnim pogoršanjem hronične opstruktivne plućne bolesti - komparativna studija
Şahin Füsun, Filiz-Koşar Ayşe, Feyza-Aslan Ayşe, Yigitbaş Burcu, Uslu Berat
University of Health Sciences/Yedikule Chest Disease and Thoracic Surgery Health Practice and Research Center, Department of Chest Diseases, Istanbul, Turkey

e-adresa: fusunsahin19700@hotmail.com
Ključne reči: HOBP odnos neutrofila/limfocita; odnos trombocita/limfocita; biomarkeri zapaljenja
Sažetak
Uvod: Srednji nivo trombocita (MPV), odnos neutrofila i limfocita (NLR) i odnos trombocita i limfocita (PLR) su istraženi kao novi zapaljenski markeri srcanih i onkoloških bolesti. Međutim, postoji ograničen broj studija koje istražuju ove markere u hroničnoj opstruktivnoj bolesti pluca (HOBP). Cilj je bio da se ispitaju NLR, PLR i drugi markeri kao što su eozinofili, MPV, trombociti (PCT), širina širenja trombocita (PDW), širina distribucije eritrocita (RDW), Creaktivni protein (CRP) kod pacijenata sa stabilnim i akutnim pogoršanjem HOBP Metode: Ispitivani su stabilna HOBP (grupa 1, n = 140), HOBP sa napadom (grupa 2, n = 110), i zdrave kontrole (grupa 3, n = 50). U svim grupama analizirani su leukociti, CRP hemoglobin (Hb), RDW, trombociti, MPV, PCT, PDW, neutrofili, limfociti, eozinofili, NLR, PLR. Rezultati: Hb, leukociti, trombociti, neutrofili, eozinofili, MPV, PCT, CRP NLR, PLR bili su značajno veći, dok su limfociti bili manji u grupi 1 nego u grupi 3. Leukociti, neutrofili, RDW, CRP NLR, PLR bili su znatno viši, dok su limfociti bili bio niži u grupi 2 nego u grupi 3. Leukociti, neutorfili, RDW, CRP NLR, PLR bili su znatno viši, dok su Hb, trombociti, MPV, PCT, limfociti bili znatno niži u grupi 2 nego u grupi 1. NLR i PLR bili su značajno povećani kod pacijenata sa bronhiektazom u poređenju sa onima koji nisu u grupi 1. Zaključak: Naši rezultati istraživanja ukazuju na to da su NLR, PLR i RDW jednostavni i isplativi markeri za procenu ozbiljnosti pogoršanja i predviđanja za hospitalizaciju i dalju procenu pogoršanja kod pacijenata sa HOBP.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC6708295
DOI: 10.2478/jomb-2018-0050
objavljen u SCIndeksu: 06.02.2020.

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