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Acta medica Medianae
2019, vol. 58, br. 4, str. 94-99
jezik rada: engleski
vrsta rada: prikaz slučaja
objavljeno: 24/02/2020
doi: 10.5633/amm.2019.0414_NE_RADI
Creative Commons License 4.0
Kožne i potkožne metastaze hepatocelularnog karcinoma - prikaz tri slučaja
aClinical Centre of Montenegro, Center for Abdominal Surgery, Podgorica, Montenegro
bUniversity of Montenegro, Faculty of Medicine, Department of Pathology + Clinical Centre of Montenegro, Podgorica, Montenegro
cClinical Centre of Montenegro, Center for Plastic and Reconstructive Surgery, Podgorica, Montenegro
dUniverzitet u Kragujevcu, Medicinski fakultet, Katedra za patološku fiziologiju

e-adresa: ljvuckovic@gmail.com

Sažetak

Hepatocelularni karcinom (HCC) je treći najčešći uzrok smrti, imajući u vidu sve maligne tumore. Metastaze HCC u koži veoma su retke i čine svega 0,8% svih poznatih kutanih metastaza. Mi prikazujemo tri slučaja HCC sa metastazama u koži i u potkožnom tkivu, koje su bile prva manifestacija tumora. Dijagnoza je postavljena na osnovu karakterističnog histomorfološkog izgleda i ispitivanjem imunog fenotipa metastatskih lezija. U sva tri slučaja je, u metastatskom čvoru, a kasnije i u intraoperativnoj biopsiji, verifikovana jaka imunohistohemijska ekspresija AE1/AE3, EMA i HepPar1. U dva slučaja zabeleženi su i povišeni serumski nivoi AFP. Za dijagnozu ekstrahepatičnih metastaza važno je, pre svega, razlikovati sekundarne depozite u koži od uobičajenih kožnih neoproliferacija. HepPar1 je odličan marker hepatocelularne diferencijacije, koji znatno olakšava dijagnozu metastaza hepatocelularnog karcinoma.

Ključne reči

hepatocelularni karcinom; metastaze u koži; inicijalna manifestacija

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