The research focused on identifying the harms and dangers in the workplace and working environment, which could cause injury at work and/or professional disease are always interesting. The research must be monitored continuously, because some harms are not researched enough, hazards in the workplace are changing, and there are also some new ones in accordance with the actual conditions at work, represented by modern technology. One of the most damaging effects at workplace is stress. The aim is to highlight the impact of professional stress on morbidity of workers. Methods: We analyzed the data and literature in the field of occupational medicine, internal medicine, psychology, neuropsychiatry, public health, quality of life and health statistics in the part relating to the impact of stress on human health, with particular emphasis on the impact of professional stress on morbidity of workers. Results and discussions: Stress at work is a specific type of stress, which source is at the working environment. Common stressors are present in most occupations, and in some occupations specific stressors that are typical for that occupation are also present. Some of the most dangerous health problems that result from overexposure to stress are heart attack and stroke. Cardiovascular system goes through a series of changes under stress, heart rate accelerates, blood pressure raises and heart attack and stroke can occur. Stress at work can present a mental, emotional trauma and be a condition for development of mental disorders and the risk of psychiatric illness, which has been confirmed in studies. The most common psychiatric diagnosis in conjunction with stress at work are adjustment disorder, trauma-related disorders (PTSD, acute stress reaction), mood disorders (major depression, dysthymia), anxiety disorders (panic, generalized anxiety) and personality disorders (obsessive-compulsive, paranoid, borderline). Stress also causes the decline of the immune system, making the body susceptible to many infections. In addition, various problems can occur in the digestive tract, stomach inflammation, gastric and duodenal ulcers, inflammation with ulcers on the colon, irritated colon. Various changes in the mouth (ulcers, sores), tightness of some muscles (of the back and shoulders), skin (eczema, lichen) and genitals (amenorrhea, impotence, etc.), as well as the frequent need to urinate, hair loss, sudden changes in body weight, may also occur due to the large exposure to stress. Smoking, excessive drinking of alcohol and coffee, drug use, poor appetite, a great need for food, physical passivity, excessive sporting activity and excessive work are the result of wrong reactions to stress. Stress at work causes diseases and injuries of workers, increases absenteeism and reduced productivity. Conclusion: Some professions are somewhat more exposed to stress and their working conditions, occurrence of stress and its impact on health have been a research subject for a long time. The list of professions in which there is an influence of stress on the health of workers is not final because the process of proving the presence of occupational stress and its harmful effects on health in certain professions are in progress. Workers who are stressed are more difficult to concentrate, make mistakes more often and are more prone to accidents in the workplace. Extended psychological pressure can have consequences in a way of serious health problems, which lead to impaired performance and an increased incidence of absenteeism from work. Stress can and must be managed, and employers and employee organizations must cooperate to protect and improve health at work. Action against stress involves primarily the implementation of preventive measures.