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Oksidativni stres kao rani marker supkliničke hipertireoze - korelacija sa hormonskim pokazateljima
aKlinički centar Niš, Klinika za endokrinologiju, dijabetes i bolesti metabolizma
bMedicinski fakultet, Univerzitet u Mariboru, Maribor, Slovenija
Ključne reči: supklinička hipertireoza; slobodni radikali; lipidna peroksidacija; ksantin oksidaza
Sažetak
Supklinička hipertiroza se definiše kao stanje sa najčešće normalnim nivoom tiroidnih hormona, smanjenim nivoom TSH i retko izraženim znacima tirotoksikoze. Nedostatak specifičnih ranih znakova hipertireoze, zajedno sa normalnim vrednostima tiroidnih hormona, otežava ranu dijagnostiku supkliničke hipertireoze. Pacijenti sa manifestnom hipertireozom pokazivali su izraženiji disbalans u parametrima oksidativnog stresa nego pacijenti sa supkliničkom hipertireozom u odnosu na kontrolnu grupu, posebno nivo MDA u eritrocitima. Nivo lipidne peroksidacije (MDA) u plazmi bio je u rangu normalnih vrednosti kod pacijenata sa supkliničkom hipertireozom, dok kod pacijenata sa manifestnom hipertireozom u plazmi su detektovane niže vrednosti MDA. Smanjeni nivo lipidne peroksidacije u plazmi praćen je smanjenim nivoom lipoproteidna, triglicerida i holesterola, gde masne kiseline triglicerida i lipoproteina predstavljaju značajne supstrate lipidne peroksidacije u plazmi. Aktivnost ksantin-oksidaze bila je značajno povećana kod pacijenata sa manifestnom formom hipertireoze, ali bez statistički značajne razlike kod pacijenata sa supkliničkim formama bolesti. Na osnovu svega može se zaključiti da promene na nivou eritrocita mogu biti jedan od značajnih pokazatelja poremećene homeostaze slobodnih radikala i lipida u ćeliji, pa se mogu razmatrati kao mogući marker za obolevanje od manifestne hipertireoze u supkliničkim oblicima. Dobijeni rezultati mogu da ukažu i na to da rana antioksidativna terapija može da predupredi razvoj manifestne hipertireoze.
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O članku

jezik rada: srpski
vrsta rada: neklasifikovan
DOI: 10.5937/medgla1453009V
objavljen u SCIndeksu: 11.06.2015.