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2019, vol. 23, br. 1, str. 32-37
Primjena CellDesigner-a za planiranje prehrane i kontrolu sigurnosti hrane
University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, Croatia

e-adresambenkovic@pbf.hr
Ključne reči: CellDesigner; matematičko modeliranje; planiranje prehrane; sigurnost hrane
Sažetak
U ovom radu istražena je primjena programa CellDesigner 4.0 (Systems Biology Institute, Tokio, Japan) u svrhu planiranja prehrane i kontrole sigurnosti hrane na tri različita primjera: (i) modelu metabolizma glikolize, (ii) modelu metabolizma 1-C ugljikovih spojeva potpomognutih folatom i (iii) modelu metabolizma arsena u jetri. Provedena je simulacija modelakorištenjem različitih početnih koncentracijanutrijenata terazličitih aktivnosti ključnih enzima. Na temelju rezultata dobivenih simulacijom modela u programu CellDesigner može se zaključiti da upotreba računalnih alata omogućuje brze i ponovljive rezultate analiza primjenom različitih ulaznih koncentracija, kao i utjecajem različitih enzimskih aktivnosti na specifični metabolički put u ljudskom organizmu. Upotreba računalnog modeliranja za metaboličke puteve nutrijenata osigurava detaljan uvid u metaboličke procese i jednostavnu kontrolu metaboličkih reakcija koje se temeljena unosu nutrijenata. Matematičko modeliranje također omogućavapraćenje promjena, ovisno o unosu nutrijenata u stanicu, dajući uvid u ono što se događa u situacijama kada je pojedini nutrijent dominantan. Računalni pristup također pojednostavljuje predviđanjepotencijalnih kontaminanata u hrani, što je vidljivo iz primjera metabolizma arsena u jetri.
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O članku

jezik rada: srpski
vrsta rada: izvorni naučni članak
DOI: 10.5937/jpea1901032M
objavljen u SCIndeksu: 03.05.2019.

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