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Acta Facultatis Medicae Naissensis
2019, vol. 36, br. 3, str. 198-206
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 09/11/2019
doi: 10.5937/afmnai1903199F
Creative Commons License 4.0
Potencijal frakcionisanog ekstrakta biljke Mimosa pudica kao biljnog hemoterapeutika kod hepatocelularnog tumora izazvanog kadmijumom sa povišenim vrednostima alfa-fetoproteina i gama-glutamil transferaze
aCollege of Health Sciences, Niger Delta University, Faculty of Basic Medical Sciences, Department of Medical Laboratory Science, Wilberforce Island, Bayelsa State, Nigeria
bCollege of Pharmacy, University of Houston, Texas Medical Center, Department of Pharmaceutical Health Outcomes & Policy, Houston, Texas, USA

e-adresa: onyije.felix@mail.ndu.edu.ng

Sažetak

Istraživači su do sada opisali da biljka Mimosa pudica (M. pudica) poseduje i antiinflamatorna svojstva, dok su njena antikancerogena svojstva još uvek nedovoljno ispitana. Cilj ove studije bio je ispitivanje heksanske, butanolne i vodene frakcije ekstrakta lista M. pudica kao biljnog hemoterapeutika kod hepatocelularnog tumora izazvanog kadmijumom. Za potrebe ovog istraživanja korišćeno je 45 odraslih pacova soja Sprague Dawley. Pacovi su nasumično podeljeni u devet grupa (grupe A do I), pri čemu se svaka grupa sastojala od pet pacova. Hepatocelularni tumor bio je izazvan primenom kadmijuma u dozi od 0,4 mg/ml, kroz pijaću vodu, u grupama B do I, u trajanju od 50 dana. Frakcionisani ekstrakti biljke M. pudica davani su oralno u dozi od 25 mg/kg i 50mg/kg grupama D i I u trajanju od 14 dana. U međuvremenu, grupa C primila je 2,5mg/kg metoteroksata (uobičajeni lek za lečenje kancera) u narednih deset dana. Histološki slajdovi za grupe C do I pokazali su značajni histomorfološki pomak u tkivu jetre, kao i značajno smanjenje degeneracije u poređenju sa kontrolnom grupom (grupa B). Nivoi AST, ALT, ALP, gGT i AFP u grupi B (285,30 IU/l ± 4.61 IU/l, 137,30 IU/l ± 12.72 IU/l, 424,70 IU/l ± 33,5 IU/l, 6,80 IU/l ± 0,26 IU/l i 1,82 ng/ml ± 0,28 ng/ml) bili su značajno povećani u poređenju sa vrednostima kontrolne (123,30 IU/l ± 5,81 IU/l, 85,33 IU/l ± 2.40 IU/l, 253,70 IU/l ± 4,91 IU/l, 0.96 IU/l ± 0.35 IU/l i 0,37 ng/ml ± 0.05 ng/ml) i drugih tretiranih grupa. Ova studija je pokazala da biljka Mimosa pudica poseduje moguća antikancerogena svojstva. Stoga se može koristiti u potencijalnoj biljnoj hemoterapiji.

Ključne reči

biljni hemoterapeutik; hepatocelularni tumor; Mimosa pudica; mitotički aktivna ćelija; kancer

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