Metrika članka

  • citati u SCindeksu: 0
  • citati u CrossRef-u:[1]
  • citati u Google Scholaru:[=>]
  • posete u poslednjih 30 dana:7
  • preuzimanja u poslednjih 30 dana:2
članak: 6 od 11  
Back povratak na rezultate
Acta Facultatis Medicae Naissensis
2019, vol. 36, br. 3, str. 219-228
jezik rada: engleski
vrsta rada: izvorni naučni članak
objavljeno: 09/11/2019
doi: 10.5937/afmnai1903220I
Creative Commons License 4.0
Antibakterijska aktivnost eteričnog ulja Origanum compactum testirana na vaginalnim i cervikalnim kliničkim bakterijskim izolatima
aUniverzitet u Tuzli, Farmaceutski fakultet, Federacija BiH
bUniverzitet u Tuzli, Prirodno-matematički fakultet, Federacija BiH
cPrivatna zdravstvena ustanova Apoteka Rosić, Bijeljina, Bosna i Hercegovina
dUniverzitet u Nišu, Medicinski fakultet, Katedra Farmacija

e-adresa: merima.ibisevic@untz.ba

Sažetak

Origanum compactum (O. compactum) je endemična marokanska lekovita biljka. Brojne studije pokazale su da organski ekstrakti O. compactum, kao i eterično ulje i njegove glavne komponente, posjeduju širi spektar farmakoloških i terapeutskih aktivnosti kao što su antibakterijska, antifungalna, antioksidativna i antitumorska aktivnost. Ovim istraživanjem trebalo je ispitati antibakterijsku aktivnost eteričnog ulja O. compactum, koja se testirala na kliničkim bakterijskim sojevima izolovanim iz vaginalnih i cervikalnih briseva. Antibakterijska aktivnost testirana je na standardnim bakterijskim kulturama: Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 51299, Escherichia coli ATCC 25922, a zatim i na kliničkim sojevima. Za testiranje antibakterijske aktivnosti korišćene su metode agar difuzija i mikrodilucijski metod. Zone inhibicije (IZ) za standardne sojeve bile su od 31,0 mm ± 0,57 mm to 35,0 mm ± 1,15 mm. Minimalna inhibitorna koncentracija (MIC) za eterično ulje utvrđena je metodom mikrodilucije. Vrijednosti su bile u opsegu od 0,098 mg/ml do 1,562 mg/ml. Eterično ulje O. compactum pokazuje snažnu antibakterijsku aktivnost za sve testirane mikroorganizme. Antibakterijska aktivnost eteričnog ulja uveliko zavisi od glavnih komponenata: karvakrola i timola. Klinički izolati, koji su otporniji u odnosu na laboratorijske sojeve, približno jednako su osjetljivi na O. compactum eterično ulje. Ovo eterično ulje može biti idealna zamena za konvencionalne antimikrobne proizvode, naročito ako se uzme u obzir povećana otpornost na primenjene antibiotike. U budućnosti, O. compactum eterično ulje može biti opcija u lečenju ginekoloških infekcija.

Ključne reči

Reference

Aboukhalid, K., Lamiri, A., Agacka-Mołdoch, M., Doroszewska, T., Douaik, A., Bakha, M., Casanova, J., Tomi, F., Machon, N., Faiz, C.A. (2016) Chemical polymorphism of Origanum compactum grown in all natural habitats in Morocco. Chemistry & Biodiversity, 13(9): 1126-1139
Bouhdid, S., Skali, S.N., Idaomar, M., Zhiri, A., et al. (2008) Antibacterial and antioxidant activities of Origanum compactum essential oil. Afr J Biotechnol, 7(10): 1563-1570
Bouyahya, A., Guaouguaou, F.E., Nadia, D.N., Bakri, Y. (2017) Pharmacological activities and medicinal properties of endemic Moroccan medicinal plant Origanum compactum (Benth) and their main compounds. Asian Pacific Journal of Tropical Disease, 7(10): 628-640
Bouyahya, A., Abrini, J., Dakka, N., Bakri, Y. (2019) Essential oils of Origanum compactum increase membrane permeability, disturb cell membrane integrity, and suppress quorum-sensing phenotype in bacteria. Journal of Pharmaceutical Analysis, 9(5): 301-311
Bouyahya, A., Jamal, A., Edaoudi, F., et al. (2016) Origanum compactum Benth: A Review on Phytochemistry and Pharmacological Properties. Medicinal & Aromatic Plants, 05(04)
Bouyahya, A., Abrini, J., Et-Touys, A., Bakri, Y., Dakka, N. (2017) Indigenous knowledge of the use of medicinal plants in the North-West of Morocco and their biological activities. European Journal of Integrative Medicine, 13: 9-25
Clinical and Laboratory Standards Institute (CLSI) (2012) Performance standards for antimicrobial disk susceptibility tests: Approved standard. Wayne, Pennsylvania, CLSI MO2-A11. eleventh edition, ISBN 1-56238-986-6
Clinical and Laboratory Standards Institute (CLSI) (2006) Methods for dilution, antimicrobial susceptibility tests for bacteria that grow aerobically: Approved standard. Wayne, Pennsylvania, CLSI M7-A7. 7 th ed
Deans, S.G., Ritchie, G. (1987) Antibacterial properties of plant essential oils. Int J Food Microbiol, 5, 165-180
Dorman, H.J.D., Deans, S.G. (2000) Antimicrobial agents from plants: Antibacterial activity of plant volatile oils. Journal of Applied Microbiology, 88(2): 308-316
Hajlaoui, H., Mighri, H., Noumi, E., Snoussi, M., Trabelsi, N., Ksouri, R., Bakhrouf, A. (2010) Chemical composition and biological activities of Tunisian Cuminum cyminum L. essential oil: A high effectiveness against Vibrio spp. strains. Food and Chemical Toxicology, 48(8-9): 2186-2192
Hamedi, A., Akhlaghi, F., Seyedi, S.J., Kharazmi, A. (2012) Evaluation of group B Streptococci colonization rate in pregnant women and their newborn. Acta Med Iran, 50: 805-813
Helal, I.M., El-Bessoumy, A., Al-Bataineh, E., Joseph, M.R.P., Rajagopalan, P., Chandramoorthy, H.C., Ben, H.A.S. (2019) Antimicrobial Efficiency of Essential Oils from Traditional Medicinal Plants of Asir Region, Saudi Arabia over Drug Resistant Isolates. Biomed Res Int, 8928306
Hernández, T., Canales, M., Avila, J.G., García, A.M., Martínez, A., Caballero, J., de Vivar, R.A., Lira, R. (2005) Composition and antibacterial activity of essential oil of Lantana achyranthifolia Desf. (Verbenaceae). Journal of Ethnopharmacology, 96(3): 551-554
Ibrahim, F.A., Bellail, A.A., Hamad, A.M., Mecherara-Idjeri, S. (2017) Antimicrobial activities and chemical composition of the essential oil of Origanum majorana L. growing in Lybia. Inter J Pharm Pharm Sci, 8: 1-11
Longaray, D.A.P., Moschen-Pistorello, I.T., Artico, L., Atti-Serafini, L., Echeverrigaray, S. (2007) Antibacterial activity of the essential oils of Salvia officinalis L. and Salvia triloba L. cultivated in South Brazil. Food Chemistry, 100 (2), 603-608
Miladi, H., Zmantar, T., Chaabouni, Y., Fedhila, K., Bakhrouf, A., Mahdouani, K., Chaieb, K. (2016) Antibacterial and efflux pump inhibitors of thymol and carvacrol against food-borne pathogens. Microbial Pathogenesis, 99: 95-100
Nazzaro, F., Fratianni, F., de Martino, L., Coppola, R., de Feo, V. (2013) Effect of Essential Oils on Pathogenic Bacteria. Pharmaceuticals, 6(12): 1451-1474
Obata-Yasuoka, M., Ba-Thein, W., Yoshikawa, H., Tsukamoto, T., Hayashi, H. (2002) Vaginal Escherichia coli share common virulence factor profiles, serotypes and phylogeny with other extraintestinal E. coli. Microbiology, 148(9): 2745-2752
Ouedrhiri, W., Balouiri, M., Bouhdid, S., Moja, S., Chahdi, F.O., Taleb, M., Greche, H. (2016) Mixture design of Origanum compactum, Origanum majorana and Thymus serpyllum essential oils: Optimization of their antibacterial effect. Industrial Crops and Products, 89: 1-9
Oussalah, M., Caillet, S., Saucier, L., Lacroix, M. (2007) Inhibitory effects of selected plant essential oils on the growth of four pathogenic bacteria: E. coli O157:H7, Salmonella Typhimurium, Staphylococcus aureus and Listeria monocytogenes. Food Control, 18(5): 414-420
Pecarski, D., Ketin, S., Omerovic, I., et al. (2016) Chemical compositions and antimicrobial activities of oregano and thyme essential oils. Bulg Chem Commun, 48: 678-83
Saad, N.Y., Muller, C.D., Lobstein, A. (2013) Major bioactivities and mechanism of action of essential oils and their components. Flavour and Fragrance Journal, 28(5): 269-279
Sienkiewicz, M., Lysakowska, M., Ciecwierz, J., Denys, P., Kowalczyk, E. (2011) Antibacterial Activity of Thyme and Lavender Essential Oils. Medicinal Chemistry, 7(6): 674-689
Tharpe, N. (2008) Postpregnancy genital tract and wound infections. Journal of midwifery & women's health, 53(3): 236-46
Watt, S., Lanotte, P., Mereghetti, L., Moulin-Schouleur, M., Picard, B., Quentin, R. (2003) Escherichia coli Strains from Pregnant Women and Neonates: Intraspecies Genetic Distribution and Prevalence of Virulence Factors. Journal of Clinical Microbiology, 41(5): 1929-1935
Williamson, R., Le, B.C., Gutmann, L., Horaud, T. (1985) One or Two Low Affinity Penicillin-binding Proteins May Be Responsible for the Range of Susceptibility of Enterococcus faecium to Benzylpenicillin. Journal of general microbiology, 131(8): 1933-1940