|
|
References
|
|
 
|
Ashby, D.R., Gale, D.P., Busbridge, M., Murphy, K.G., Duncan, N.D., Cairns, T.D., Choi, P., i dr. (2009) Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney International, 75(9), 976-981
|
|
|
Ashby, D.R., Gale, D.P., Busbridge, M., Murphy, K.G., Duncan, N.D., Cairns, T.D., Choi, P., i dr. (2010) Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin. Haematologica, 95(3), 505-508
|
|
1 
|
Ashrafian, H. (2003) Hepcidin: The missing link between hemochromatosis and infections. Infection and Immunity, 71(12): 6693-6700
|
|
1
|
Auersperger, I., Knap, B., Jerin, A., Blagus, R., Lainscak, M., Skitek, M., Skof, B. (2012) The effects of 8 weeks of endurance running on hepcidin concentrations, inflammatory parameters, and iron status in female runners. International Journal of Sport Nutrition and Exercise Metabolism, 22(1): 55-63
|
|
|
Babitt, J.L., Huang, F.W., Wrighting, D.M., Xia, Y., Sidis, Y., Samad, T.A., Lin, H.Y., i dr. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nature Genetics, 38(5), 531-539
|
|
|
Babitt, J.L., Huang, F.W., Xia, Y., Sidis, Y., Andrews, N.C., Lin, H.Y. (2007) Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. Journal of Clinical Investigation, 117(7), 1933-1939
|
|
|
Banzet, S., Sanchez, H., Chapot, R., Bigard, X., Vaulont, S., Koulmann, N. (2012) Interleukin-6 contributes to hepcidin mRNA increase in response to exercise. Cytokine, 58(2), 158-161
|
|
|
Brugnara, C. (2008) An immunoassay for human serum hepcidin at last: Ganz klar?. Blood, 112(10), 3922-3923
|
|
|
Christoulas, K., Karamouzis, M., Mandroukas, K. (2011) 'Living high - training low' vs. 'living high - training high': Erythropoietic responses and performance of adolescent cross-country skiers. Journal of Sports Medicine and Physical Fitness, 51(1), 74-81
|
|
|
Chung, B., Chaston, T., Marks, J., Srai, S.K., Sharp, P.A. (2009) Hepcidin decreases iron transporter expression in vivo in mouse duodenum and spleen and in vitro in THP-1 macrophages and intestinal Caco-2 cells. Journal of Nutrition, 139(8): 1457-1462
|
|
|
Cooke, K.S., Hinkle, B., Salimi-Moosavi, H., Foltz, I., King, C., Rathanaswami, P., Winters, A., Steavenson, S., Begley, C. G., Molineux, G., Sasu, B.J. (2013) A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates. Blood, 122(17): 3054-3061
|
|
|
Corradini, E., Garuti, C., Montosi, G., Ventura, P., Andriopoulos, B., Lin, H.Y., Pietrangelo, A., Babitt, J.L. (2009) Bone morphogenetic protein signaling is impaired in an Hfe knockout mouse model of hemochromatosis. Gastroenterology, 137(4): 1489-1497
|
|
|
Corradini, E., Meynard, D., Wu, Q., Chen, S., Ventura, P., Pietrangelo, A., Babitt, J.L. (2011) Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology, 54(1): 273-284
|
|
|
Delaby, C., Pilard, N., Gonçalves, A.S., Beaumont, C., Canonne-Hergaux, F. (2005) Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood, 106(12): 3979-3984
|
|
|
Domínguez, R., Vicente-Campos, D., Vicente-Campos, D., Chicharro, J. (2014) Hepcidin response to exercise: A review. Turkish Journal of Endocrinology and Metabolism, 18(3): 84-91
|
|
|
Farnaud, S., Patel, A., Evans, R.W. (2006) Modelling of a metal-containing hepcidin. BioMetals, 19(5): 527-533
|
|
|
Farnaud, S., Rapisarda, C., Bui, T., Drake, A., Cammack, R., Evans, R.W. (2008) Identification of an iron-hepcidin complex. Biochemical Journal, 413(3): 553-557
|
|
|
Forejtnikovà, H., Vieillevoye, M., Zermati, Y., Lambert, M., Pellegrino, R.M., Guihard, S., Gaudry, M., Camaschella, C., Lacombe, C., Roetto, A., Mayeux, P., Verdier, F. (2010) Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis. Blood, 116(24): 5357-5367
|
|
|
Fung, E., Sugianto, P., Hsu, J., Damoiseaux, R., Ganz, T., Nemeth, E. (2013) High-throughput screening of small molecules identifies hepcidin antagonists. Molecular Pharmacology, 83(3): 681-690
|
|
1
|
Galesloot, T.E., Vermeulen, S.H., Geurts-Moespot, A.J., Klaver, S.M., Kroot, J.J., van Tienoven, D., Wetzels, J.F.M., Kiemeney, L.A.L.M., Sweep, F.C., Den, H.M., Swinkels, D.W. (2011) Serum hepcidin: Reference ranges and biochemical correlates in the general population. Blood, 117(25): e218-e225
|
|
|
Ganz, T., Olbina, G., Girelli, D., Nemeth, E., Westerman, M. (2008) Immunoassay for human serum hepcidin. Am Soc Hematology, Intrinsic LifeSciences, 112(10), 4292-4298
|
|
|
Ganz, T. (2011) Hepcidin and iron regulation, 10 years later. Blood, 117(17): 4425-4433
|
|
|
Gaudard, A., Varlet-Marie, E., Bressolle, F., Audran, M. (2003) Drugs for increasing oxygen transrort and their potential use in doping: A review. Sports Medicine, 33(3): 187-212
|
|
|
Goetze, O., Schmitt, J., Spliethoff, K., Theurl, I., Weiss, G., Swinkels, D.W., Tjalsma, H., Maggiorini, M., Krayenbühl, P., Rau, M., Fruehauf, H., Wojtal, K.A., Müllhaupt, B., Fried, M., Gassmann, M. (2013) Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology, 58(6): 2153-2162
|
|
|
Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin, Y., Romero, M.F., Boron, W.F., Nussberger, S., Gollan, J.L., Hediger, M.A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature, 388(6641): 482-488
|
|
|
Guo, W., Bachman, E., Li, M., Roy, C.N., Blusztajn, J., Wong, S., Chan, S.Y., Serra, C., Jasuja, R., Travison, T.G., Muckenthaler, M.U., Nemeth, E., Bhasin, S. (2013) Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell, 12(2): 280-291
|
|
1
|
Hentze, M.W., Muckenthaler, M.U., Galy, B., Camaschella, C. (2010) Two to tango: Regulation of mammalian iron metabolism. Cell, 142(1): 24-38
|
|
|
Hunter, H.N., Fulton, D. B., Ganz, T., Vogel, H.J. (2002) The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. Journal of Biological Chemistry, 277(40): 37597-37603
|
|
|
Ikeda, Y., Tajima, S., Izawa-Ishizawa, Y., Kihira, Y., Ishizawa, K., Tomita, S., Tsuchiya, K., Tamaki, T. (2012) Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. PLoS One, 7(7): 1-9
|
|
|
Jordan, J.B., Poppe, L., Haniu, M., Arvedson, T., Syed, R., Li, V., Kohno, H., Kim, H., Schnier, P.D., Harvey, T.S., Miranda, L.P., Cheetham, J., Sasu, B.J. (2009) Hepcidin revisited, disulfide connectivity, dynamics, and structure. Journal of Biological Chemistry, 284(36): 24155-24167
|
|
|
Kawabata, H., Fleming, R.E., Gui, D., Moon, S.Y., Saitoh, T., O'Kelly, J., Umehara, Y., Wano, Y., Said, J.W., Koeffler, H. P. (2005) Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood, 105(1): 376-381
|
|
|
Kemna, E.H.J.M., Tjalsma, H., Podust, V.N., Swinkels, D.W. (2007) Mass spectrometry-based hepcidin measurements in serum and urine: Analytical aspects and clinical implications. Clinical Chemistry, 53(4): 620-628
|
|
|
Knutson, M.D., Oukka, M., Koss, L.M., Aydemir, F., Wessling-Resnick, M. (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proceedings of the National Academy of Sciences of the United States of America, 102(5): 1324-1328
|
|
|
Kong, W., Chang, Y., Wang, S., Zhai, X., Shang, J., Li, L., Duan, X. (2008) Effect of erythropoietin on hepcidin, DMT1 with IRE, and hephaestin gene expression in duodenum of rats. Journal of Gastroenterology, 43(2): 136-143
|
|
|
Kong, W., Zhao, S., Duan, X., Yang, Z., Qian, Z., Chang, Y. (2008) Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats. Journal of Cellular Biochemistry, 104(2): 629-641
|
|
|
Kong, W., Gao, G., Chang, Y. (2014) Hepcidin and sports anemia. Cell & Bioscience, 4(1): 1-11
|
|
|
Krantz, S.B. (1991) Erythropoietin. Blood, 77(3): 419-434
|
|
|
Krause, A., Neitz, S., Mägert, H., Schulz, A., Forssmann, W., Schulz-Knappe, P., Adermann, K. (2000) LEAP-1: A novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Letters, 480(2-3): 147-150, 11, the nucleotide sequence data reported in this paper have been submitted to the GenBank/EBI Data Bank with accession number AJ277280
|
|
|
Kroot, J.J.C., Laarakkers, C.M.M., Geurts-Moespot, A.J., Grebenchtchikov, N., Pickkers, P., van Ede, A.E., Peters, H.P., van Dongen-Lases, E., Wetzels, J.F.M., Sweep, F.C.G.J., Tjalsma, H., Swinkels, D.W. (2010) Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disorders. Clinical Chemistry, 56(10): 1570-1579
|
|
|
Kroot, J.J.C., Tjalsma, H., Fleming, R.E., Swinkels, D.W. (2011) Hepcidin in human iron disorders: Diagnostic implications. Clinical Chemistry, 57(12): 1650-1669
|
|
|
Kulaksiz, H., Theilig, F., Bachmann, S., Gehrke, S.G., Rost, D., Janetzko, A., Cetin, Y., Stremmel, W. (2005) The iron-regulatory peptide hormone hepcidin: Expression and cellular localization in the mammalian kidney. Journal of Endocrinology, 184(2): 361-370
|
|
|
Kwapisz, J., Slomka, A., Zekanowska, E. (2009) Hepcidin and its role in iron homeostasis. Ejifcc, 20(2): 124-128
|
|
|
Laftah, A.H., Ramesh, B., Simpson, R.J., Solanky, N., Bahram, S., Schümann, K., Debnam, E.S., Srai, S.K.S. (2004) Effect of hepcidin on intestinal iron absorption in mice. Blood, 103(10): 3940-3944
|
|
|
Latour, C., Kautz, L., Besson-Fournier, C., Island, M., Canonne-Hergaux, F., Loréal, O., Ganz, T., Coppin, H., Roth, M. (2014) Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology, 59(2): 683-694
|
|
|
Lin, L., Goldberg, Y. P., Ganz, T. (2005) Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood, 106(8): 2884-2889
|
|
|
Liu, Q., Davidoff, O., Niss, K., Haase, V.H. (2012) Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. Journal of Clinical Investigation, 122(12): 4635-4644
|
|
|
Liu, Y.-Q., Chang, Y.-Z., Zhao, B., Wang, H.-T., Duan, X.-L. (2011) Does hepatic hepcidin play an important role in exercise-associated anemia in rats?. International Journal of Sport Nutrition and Exercise Metabolism, 21, 19-26
|
|
|
Liu, Y.Q., Duan, X.L., Chang, Y.Z., Wang, H.T., Qian, Z.M. (2006) Molecular analysis of increased iron status in moderately exercised rats. Molecular and Cellular Biochemistry, 282(1-2): 117-123
|
|
|
Magazanik, A., Weinstein, Y., Dlin, R.A., Derin, M., Schwartzman, S., Allalouf, D. (1988) Iron deficiency caused by 7 weeks of intensive physical exercise. European Journal of Applied Physiology and Occupational Physiology, 57(2): 198-202
|
|
|
Margeli, A., Skenderi, K., Tsironi, M., Hantzi, E., Matalas, A., Vrettou, C., Kanavakis, E., Chrousos, G., Papassotiriou, I. (2005) Dramatic elevations of interleukin-6 and acute-phase reactants in athletes participating in the ultradistance foot race Spartathlon: Severe systemic inflammation and lipid and lipoprotein changes in protracted exercise. Journal of Clinical Endocrinology & Metabolism, 90(7): 3914-3918
|
|
|
Mcclung, J.P. (2012) Iron status and the female athlete. Journal of Trace Elements in Medicine and Biology, 26(2-3): 124-126
|
|
|
Melino, S., Garlando, L., Patamia, M., Paci, M., Petruzzelli, R. (2005) A metal-binding site is present in the amino terminal region of the bioactive iron regulator hepcidin-25. Journal of Peptide Research, 66(suppl. 1): 65-71
|
|
|
Mena, N.P., Esparza, A., Tapia, V., Valdés, P., Núñez, M.T. (2008) Hepcidin inhibits apical iron uptake in intestinal cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(1): G192-G198
|
|
|
Merkel, D., Huerta, M., Grotto, I., Blum, D., Rachmilewitz, E., Fibach, E., Epstein, Y., Shpilberg, O. (2009) Incidence of anemia and iron deficiency in strenuously trained adolescents: Results of a longitudinal follow-up study. Journal of Adolescent Health, 45(3): 286-291
|
|
|
Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., Roth, M. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nature Genetics, 41(4): 478-481
|
|
|
Nemeth, E., Preza, G.C., Jung, C., Kaplan, J., Waring, A.J., Ganz, T. (2006) The N-terminus of hepcidin is essential for its interaction with ferroportin: Structure-function study. Blood, 107(1): 328-333
|
|
2
|
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B.K., Ganz, T. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. Journal of Clinical Investigation, 113(9): 1271-1276
|
|
|
Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., Camaschella, C. (2005) Hepcidin is decreased in TFR2 hemochromatosis. Blood, 105(4): 1803-1806
|
|
1
|
Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., Ward, D.M., Ganz, T., Kaplan, J. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, New York, 306(5704): 2090-2093, N.Y
|
|
|
Nemeth, E., Valore, E.V., Territo, M., Schiller, G., Lichtenstein, A., Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 101(7): 2461-2463
|
|
|
Newlin, M.K., Williams, S., Mcnamara, T., Tjalsma, H., Swinkels, D.W., Haymes, E.M. (2013) The effects of acute exercise bouts on hepcidin in women. Int J Sport Nutr Exerc Metab, 23, 178-186
|
|
2
|
Nicolas, G., Chauvet, C., Viatte, L., Danan, J.L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., Vaulont, S. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. Journal of Clinical Investigation, 110(7): 1037-1044
|
|
|
Nicolas, G., Viatte, L., Bennoun, M., Beaumont, C., Kahn, A., Vaulont, S. (2002) Hepcidin: A new iron regulatory peptide. Blood Cells, Molecules, and Diseases, 29(3): 327-335
|
|
|
Nishimoto, N., Kanakura, Y., Aozasa, K., Johkoh, T., Nakamura, M., Nakano, S., Nakano, N., Ikeda, Y., Sasaki, T., Nishioka, K., Hara, M., Taguchi, H., Kimura, Y., Kato, Y., Asaoku, H. (2005) Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood, 106(8): 2627-2632
|
|
|
Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., Pedersen, B.K. (1999) Pro and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology, 515(Pt 1): 287-291
|
|
2
|
Pak, M., Lopez, M.A., Gabayan, V., Ganz, T., Rivera, S. (2006) Suppression of hepcidin during anemia requires erythropoietic activity. Blood, 108(12): 3730-3735
|
|
|
Papanikolaou, G., Samuels, M.E., Ludwig, E.H., Macdonald, M.L.E., Franchini, P.L., Dubé, M., Andres, L., Macfarlane, J., Sakellaropoulos, N., Politou, M., Nemeth, E., Thompson, J., Risler, J.K. (2004) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nature Genetics, 36(1): 77-82
|
|
|
Park, C.H., Valore, E.V., Waring, A.J., Ganz, T. (2001) Hepcidin: A urinary antimicrobial peptide synthesized in the liver. Journal of Biological Chemistry, 276(11): 7806-7810
|
|
|
Pedersen, B.K., Febbraio, M.A. (2012) Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8(8), 457-465
|
|
|
Pedersen, B.K., Hoffman-Goetz, L. (2000) Exercise and the immune system: Regulation, integration, and adaptation. Physiological Reviews, 80(3): 1055-1081
|
|
|
Pedersen, B.K., Steensberg, A., Schjerling, P. (2001) Muscle-derived interleukin-6: Possible biological effects. Journal of Physiology, 536(2): 329-337
|
|
|
Peeling, P. (2010) Exercise as a mediator of hepcidin activity in athletes. European Journal of Applied Physiology, 110(5): 877-883
|
|
|
Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D. (2009) Training surface and intensity: Inflammation, hemolysis, and hepcidin expression. Medicine and Science in Sports and Exercise, 41(5): 1138-1145
|
|
|
Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D. (2009) Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity. European Journal of Applied Physiology, 106(1): 51-59
|
|
|
Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E.T., Swinkels, D.W., Trinder, D. (2009) Effects of exercise on hepcidin response and iron metabolism during recovery. International Journal of Sport Nutrition and Exercise Metabolism, 19(6): 583-597
|
|
|
Peslova, G., Petrak, J., Kuzelova, K., Hrdy, I., Halada, P., Kuchel, P.W., Soe-Lin, S., Ponka, P., Sutak, R., Becker, E., Huang, M.L., Suryo, R.Y., Richardson, D.R., Vyoral, D. (2009) Hepcidin, the hormone of iron metabolism, is bound specifically to a-2-macroglobulin in blood. Blood, 113(24): 6225-6236
|
|
|
Peters, H.P.E., Laarakkers, C.M.M., Swinkels, D.W., Wetzels, J.F.M. (2010) Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate. Nephrology Dialysis Transplantation, 25(3): 848-853
|
|
|
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., Loréal, O. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. Journal of Biological Chemistry, 276(11): 7811-7819
|
|
|
Piloto, N., Teixeira, H.M., Teixeira-Lemos, E., Parada, B., Garrido, P., Sereno, J., Pinto, R., Carvalho, L., Costa, E., Belo, L., Santos-Silva, A., Teixeira, F.M., Reis, F. (2009) Erythropoietin promotes deleterious cardiovascular effects and mortality risk in a rat model of chronic sports doping. Cardiovascular Toxicology, 9(4): 201-210
|
|
|
Pinto, J.P., Ribeiro, S., Pontes, H., Thowfeequ, S., Tosh, D., Carvalho, F., Porto, G. (2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPa. Blood, 111(12): 5727-5733
|
|
|
Poli, M., Girelli, D., Campostrini, N., Maccarinelli, F., Finazzi, D., Luscieti, S., Nai, A., Arosio, P. (2011) Heparin: A potent inhibitor of hepcidin expression in vitro and in vivo. Blood, 117(3): 997-1004
|
|
|
Qian, Z.M., Xiao, D.S., Tang, P.L., Yao, F.Y.D., Liao, Q.K. (1999) Increased expression of transferrin receptor on membrane of erythroblasts in strenuously exercised rats. Journal of Applied Physiology, 87(2): 523-529
|
|
|
Ramey, G., Deschemin, J.-C., Durel, B., Canonne-Hergaux, F., Nicolas, G., Vaulont, S. (2010) Hepcidin targets ferroportin for degradation in hepatocytes. Haematologica, 95(3): 501-504
|
|
|
Ramirez, J., Schaad, O., Durual, S., Cossali, D., Docquier, M., Beris, P., Descombes, P., Matthes, T. (2009) Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. British Journal of Haematology, 144(2): 251-262
|
|
|
Ramos, E., Kautz, L., Rodriguez, R., Hansen, M., Gabayan, V., Ginzburg, Y., Ganz, T., i dr. (2011) Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. 53(4), 1333-1341
|
|
|
Reinke, S., Taylor, W.R., Duda, G.N., von Haehling, S., Reinke, P., Volk, H., Anker, S.D., Doehner, W. (2012) Absolute and functional iron deficiency in professional athletes during training and recovery. International Journal of Cardiology, 156(2): 186-191
|
|
|
Rivera, S., Nemeth, E., Gabayan, V., Lopez, M.A., Farshidi, D., Ganz, T. (2005) Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood, 106(6), 2196-2199
|
|
|
Roecker, L., Kowoll, R., Fraszi, W., Battal, K., Brechtel, L., Brachmann, S., Kiesewettwr, H., i dr. (2006) Observation of serum erythropoietin concentrations in female athletes for up to eight days after a marathon run. Clin Lab, 52(9-10), 511-513
|
|
|
Roecker, L., Meier-Buttermilch, R., Brechtel, L., Nemeth, E., Ganz, T. (2005) Iron-regulatory protein hepcidin is increased in female athletes after a marathon. European Journal of Applied Physiology, 95(5-6), 569-571
|
|
|
Schranz, M., Bakry, R., Creus, M., Bonn, G., Vogel, W., Zoller, H. (2009) Activation and inactivation of the iron hormone hepcidin: Biochemical characterization of prohepcidin cleavage and sequential degradation to N-terminally truncated hepcidin isoforms. Blood Cells, Molecules, and Diseases, 43(2), 169-179
|
|
|
Schwoebel, F., van Eijk, L.T., Zboralski, D., Sell, S., Buchner, K., Maasch, C., Klussmann, S., i dr. (2013) The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood, 121(12), 2311-2315
|
|
|
Sim, M., Dawson, B., Landers, G., Swinkels, D.W., Tjalsma, H., Trinder, D., Peeling, P. (2013) Effect of exercise modality and intensity on postexercise interleukin-6 and hepcidin levels. International Journal of Sport Nutrition and Exercise Metabolism, 23(2), 178-186
|
|
|
Son, H.J., Kim, H.J., Kim, J.H., Ohno, H., Kim, C.K. (2012) Erythropoietin, 2,3 DPG, oxygen transport capacity, and altitude training in adolescent alpine skiers. Aviation Space and Environmental Medicine, 83(1), 50-53
|
|
|
Song, S.N.J., Tomosugi, N., Kawabata, H., Ishikawa, T., Nishikawa, T., Yoshizaki, K. (2010) Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease. Blood, 116(18), 3627-3634
|
|
|
Sow, F.B., Florence, W.C., Satoskar, A.R., Schlesinger, L.S., Zwilling, B.S., Lafuse, W.P. (2007) Expression and localization of hepcidin in macrophages: A role in host defense against tuberculosis. Journal of Leukocyte Biology, 82(4), 934-945
|
|
|
Sumboonnanonda, A., Malasit, P., Tanphaichitr, V., Ong-Ajyooth, S., Sunthornchart, S., Pattanakitsakul, S., Vongjirad, A., i dr. (1998) Renal tubular function in betathalassemia. Pediatr Nephrol, 12, 80/83
|
|
|
Swinkels, D.W., Girelli, D., Laarakkers, C., Kroot, J., Campostrini, N., Kemna, E.H.J.M., Tjalsma, H. (2008) Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry. PLoS One, 3(7), 1-7
|
|
|
Tanno, T., Bhanu, N.V., Oneal, P.A., Goh, S.H., Staker, P., Lee, Y.T., Miller, J.L., i dr. (2007) High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature Medicine, 13(9), 1096-1101
|
|
|
Tanno, T., Porayette, P., Sripichai, O., Noh, S.J., Byrnes, C., Bhupatiraju, A., Miller, J.L., i dr. (2009) Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood, 114(1), 181-186
|
|
|
Theurl, I., Schroll, A., Sonnweber, T., Nairz, M., Theurl, M., Willenbacher, W., Weiss, G., i dr. (2011) Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood, 118(18), 4977-4984
|
|
|
Tian, Y., Zhao, J., Zhao, B., Gao, Q., Xu, J., Liu, D. (2012) The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise. Biological Trace Element Research, 147(1-3), 261-266
|
|
|
Tomosugi, N., Kawabata, H., Wakatabe, R., Higuchi, M., Yamaya, H., Umehara, H., Ishikawa, I. (2006) Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System. Blood, 108(4), 1381-1387
|
|
|
Troadec, M., Lainé, F., Daniel, V., Rochcongar, P., Ropert, M., Cabillic, F., Perrin, M., Morcet, J., Loréal, O., Olbina, G., Westerman, M., Nemeth, E., Ganz, T., Brissot, P. (2009) Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. European Journal of Applied Physiology, 106(3): 435-443
|
|
|
Troutt, J.S., Rudling, M., Persson, L., Ståhle, L., Angelin, B., Butterfield, A.M., Schade, A.E., Cao, G., Konrad, R.J. (2012) Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration. Clinical Chemistry, 58(8): 1225-1232
|
|
|
Tselepis, C., Ford, S.J., Mckie, A.T., Vogel, W., Zoller, H., Simpson, R.J., Diaz, C.J., Iqbal, T.H., Ward, D.G. (2010) Characterization of the transition-metal-binding properties of hepcidin. Biochemical Journal, 427(2): 289-296
|
|
|
Valore, E.V., Ganz, T. (2008) Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells, Molecules, and Diseases, 40(1): 132-138
|
|
|
van de Vosse, E., van Agtmael, M.A. (2007) Targets of anticytokine therapy and the risk of infections in humans and mice. Current Opinion in Rheumatology, 19(6): 626-635
|
|
|
Vittoria, M., Falzacappa, V., Spasic, M.V., Kessler, R., Stolte, J., Hentze, M.W., Muckenthaler, M.U. (2015) STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood, 109(1): 353-359
|
|
|
Vokurka, M., Krijt, J., Šulc, K., Nečas, E. (2006) Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiological research, 55(6): 667-74
|
|
|
Wallace, D.F., Summerville, L., Crampton, E.M., Frazer, D.M., Anderson, G.J., Subramaniam, V.N. (2009) Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology, 50(6), 1992-2000
|
|
|
Wan, L., Bellomo, R., di Giantomasso, D., Ronco, C. (2003) The pathogenesis of septic acute renal failure. Curr Opin Crit Care, 9, 496-502
|
|
|
Wrighting, D.M., Andrews, N.C. (Blood) Interleukin-6 induces hepcidin expression through STAT3. Blood, 108(9), 3204-3209
|
|
|
Yu, P.B., Hong, C.C., Sachidanandan, C., Babitt, J.L., Deng, D.Y., Hoyng, S.A., Peterson, R.T., i dr. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol, 4(1), 33-41
|
|
|
Zhang, A.-S. (2010) Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis. Adv. Nutr, 1, 38-45
|
|
|
Zhang, S.P., Wang, Z., Wang, L.X., Liu, S.J. (2011) AG490: An inhibitor of hepcidin expression in vivo. World Journal of Gastroenterology, 17(45): 5032-5034
|
|
|
|
|