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Acta Facultatis Medicae Naissensis
2020, vol. 37, br. 2, str. 131-138
"Off-label" primena lekova u dermatologiji - izazovi novih puteva primene određenih starih lekova
Tasić-Kostov Marija, Ilić Dušan
Univerzitet u Nišu, Medicinski fakultet, Katedra Farmacija

e-adresa: marijatk@medfak.ni.ac.rs
Projekat:
This research was supported by the Faculty of Medicine University of Niš Internal Scientific Project titled: "Investigation of selected synthetic and herbal medicinal substances for off-label skin application."

Ključne reči: "off-label" primena lekova; dermatologija; magistralni lekovi; nosači za lekove
Sažetak
"Off-label" upotreba lekova, tj. upotreba lekova bez dozvole, podrazumeva propisivanje lekova, u smislu doze, indikacija, farmaceutskog oblika i puta primene ili ciljne grupe bolesnika, za koje ne postoji zvanično odobrenje. U poslednje vreme ističu se nove indikacije za određene lekove. "Off-label" upotreba lekova češća je u dermatologiji u odnosu na druge specijalnosti. Ti lekovi uglavnom su dostupni u obliku magistralno izrađenih preparata za lokalnu upotrebu na koži; u tom slučaju obično se ne poklanja dovoljno pažnje izboru nosača i bezbednosti lokalno primenjenog leka, koji je inače indikovan za sistemsku primenu. Štaviše, podloge (baze) koje se tradicionalno koriste kao nosači za magistralno izrađene lekove obično su stabilizovane surfaktantima koji mogu da iritiraju kožu. To svakako nije povoljno imajući u vidu da se stanje inflamatornih dermatoza može pogoršati kada se iste izlažu iritansima. U ovom radu dat je prikaz nekoliko starijih sistemskih lekova, koji se u poslednje vreme upotrebljavaju u lokalnom tretmanu čestih dermatoloških oboljenja i to van zvanično odobrene indikacije. Izbor lekova napravljen je na osnovu informacija o najčešćim magistralnim preparatima ovog tipa, izrađenih prema receptu lekara u apotekama. Cilj rada bio je i prikaz dostupnih naučnih informacija koje se tiču dva, po našem mišljenju, najveća nedostatka "off-label" lokalne upotrebe lekova u dermatologiji: bezbednosti primene finalnih formulacija na kožu i izbora nosača za određene lekove, u smislu njihove stabilnosti i bezbednosti primene.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/afmnai37-25282
objavljen u SCIndeksu: 06.08.2020.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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