The security of people and property is one of the basic premises of the business of each company. Security as an important function of management of the organization, particularly evident in companies engaged in the production of explosives and flammable substances. In the category of security risk companies are the defense industry companies. Recently, these findings have been confirmed through several industrial accidents with serious consequences. Security vulnerability of these companies is reflected primarily in the sensitivity of certain production and technological processes in terms of exposure to destructive influences and possible occurrence of fire, explosion of a hazardous gases and liquids. Reasons for increased surveillance and a higher safety level can be found in the volume and sensitivity of explosives and flammable substances on a daily basis participate in the processes of production. Considering aforementioned clearly imposes the task of preventive action and preventing accidents and diminishes the effects of their possible manifestation (if they occur). This paper considers the most characteristic of industrial accidents that have occurred in the defense industry from the point of view of their phenomenological characteristics, with a view to identifying the causes of these phenomena and take measures to correct them, in order to prevent repeated and similar events. As the most relevant, addressed the issues of prevention of accidents and safety activities of operators in terms of prevention and elimination of consequences. Also, paper presents singled out the conclusions derived by treating these very complex and in modern times most of the current problems, which requires the full attention of all security subjects in the country, in order to prevent extremely dangerous and even disastrous consequences for security facilities in the Republic of Serbia and the destruction of valuable and scarce resources.