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2021, vol. 149, br. 3-4, str. 142-148
Analiza biohemijskih markera u pljuvački i korelacija sa kliničkim parametrima kod obolelih od agresivne parodontopatije, pre i posle terapije
aUniverzitet u Kragujevcu, Fakultet medicinskih nauka
bUniverzitet u Beogradu, Stomatološki fakultet, Katedra za dentalnu patologiju
cUniverzitet u Nišu, Medicinski fakultet, Stomatološka klinika
dUniverzitet u Beogradu, Stomatološki fakultet

e-adresadrivandozic@gmail.com
Ključne reči: agresivna parodontopatija; intraćelijski enzimi; pljuvačka
Sažetak
Uvod/Cilj Agresivna parodontopatija (AP) je progresivno oboljenje koje dovodi do oštećenja parodontalnih tkiva. Cilj istraživanja bio je analiza intraćelijskih enzima aspartat-aminotransferaze, alanin-aminotransferaze, alkalne fosfataze, kisele fosfataze i elektrolita (kalcijuma, fosfata) u pljuvački ispitanika sa AP i njihova korelacija sa kliničkim parametrima, pre i posle terapije. Metode rada U studiju je uključeno 30 pacijenata sa AP (eksperimentalna grupa) i 35 ispitanika sa zdravim parodoncijumom (kontrolna grupa). Intraćelijski enzimi (aspartat-aminotransferaze, alanin-aminotransferaze, alkalne fosfataze, kisele fosfataze) i elektroliti (kalcijum, fosfati) analizirani su u nestimulisanoj pljuvački ispitanika sa AP, pre i posle terapije (bazične i hirurške) i u uzorcima pljuvačke ispitanika kontrolne grupe. Analiza biohemijskih markera je vršena kinetičkim metodama, pomoću komercijalnih reagenasa. Rezultati Koncentracije biohemijskih markera aspartataminotransferaze (28,18 ± 25,16), alanin-aminotransferaze (5,48 ± 5,14), alkalne fosfataze (31,13 ± 37,79), kisele fosfataze (17,53 ± 14,77), kalcijuma (2,80 ± 1,97), fosfata (4,43 ± 1,92) u pljuvački ispitanika eksperimentalne grupe bile su statistički značajno veće u odnosu na kontrolnu grupu (p = 0,000; p = 0,001). Vrednosti kliničkih parametara su bile statistički značajno niže nakon sprovedene parodontalne terapije (p = 0,000). Spirmanovim testom uočena je statistička korelacija između vrednosti aspartat-aminotransferaze i vrednosti indeksa mekih naslaga (r = -0,444; p = 0,026) i indeksa čvrstih naslaga (r = -0,513; p = 0,009). Nakon terapije je postojala korelacija između vrednosti plak indeksa i nivoa alkalne fosfataze u pljuvački (p = 0,020). Zaključak Sprovedeno istraživanje doprineće boljem razumevanju i standardizaciji biomarkera u pljuvački koji bi pomogli u dijagnostikovanju i praćenju sprovedene tarapije kod obolelih od AP.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.2298/SARH200205103P
primljen: 05.02.2020.
prihvaćen: 29.10.2020.
objavljen onlajn: 06.11.2020.
objavljen u SCIndeksu: 18.05.2021.

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