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2021, vol. 68, br. 2, str. 68-78
Ispitivanje rendgenkontrastnosti i citotoksičnosti ALBO-DENTA - novog kalcijum-silikatnog cementa sa dodatkom stroncijumkarbonata
aUniverzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković'
bUniverzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča + Univerzitet u Beogradu, Stomatološki fakultet
cUniverzitet u Beogradu, Stomatološki fakultet
dALBOS d.o.o., Beograde

e-adresavukoman@vin.bg.ac.rs
Projekat:
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (institucija: Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (MPNTR - 451-03-68/2020-14/200017)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (institucija: Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (MPNTR - 451-03-68/2020-14/200007)
451-02-818/2021-09/20, Projekat bilateralne saradnje između Ministarstva prosvete, nauke i tehnološkog razvoja Republike Srbije i Ministarstva nauke i tehnologije Narodne Republike Kine

Ključne reči: kalcijum-silikat; stroncijum-karbonat; rendgenkontrast; citotoksičnost; endodoncija
Sažetak
Uvod: Kalcijum-silikatni (KS) dentalni cementi se koriste u brojnim kliničkim indikacijama u stomatologiji koje uključuju direktno prekrivanje pulpe, retrogradnu hirurgiju korena zuba, lečenje perforacija i apeksogenezu/apeksifikaciju. Materijali i metode: U istraživanju je korišćen novosintetisani cement na bazi KS sa dodatkom SrCO3 kao kontrastnog agensa ALBO-DENTA, dok su kao kontrola korišćeni cement Portland (PC, Aalborg, Denmark) i ProRoot MTA (MTA, Tulsa Dental, USA). Rendgenokontrasnost je ispitivana digitalnom radiografijom primenom aparata Trophy, sa namerom da se precizno odredi minimum kontrastnog agensa koji zadovoljava zahteve standarda ISO za rendgenkontrastnost. Biokompatibilnost materijala je ispitana in vitro, u kulturi ćelija mišjeg fibrosarkoma L929 tretiranoj ekstraktima ispitivanih materijala. Ćelijska morfologija je praćena upotrebom fazno-kontrastne mikroskopije, dok je vijabilnost ćelija utvrđivana kristal violet (KV) i 3-(4,5-dimetiltiazol-2-yl)-2,5-difenfl-tetrazolium bromid (MTT) esejima. Rezultati: Ispitivanje rendgenkontrastnosti je pokazalo da dodatak 30% SrCO3 dovodi do zadovoljavajućeg kontrasta materijala (3,45 mm Al). Analiza citotoksičnosti KV i MTT metodom je pokazala da čisti ekstrakt ALBO-DENTA pokazuje bolju biokompatibilnost u poređenju sa PC i MTA, dok serijska razblaženja ekstrakta ispitivanog cementa, kao i PC i MTA, nisu uticala na vijabilitet ćelija L929. Zaključci Novi cement na bazi KS - ALBO-DENT pokazao je zavodovoljavajuću rendgenkontrastnost i odgovarajuću biokompatibilnost.
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O članku

jezik rada: engleski
vrsta rada: izvorni naučni članak
DOI: 10.2298/SGS2102068D
primljen: 23.02.2021.
prihvaćen: 26.05.2021.
objavljen u SCIndeksu: 22.07.2021.
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