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2021, vol. 10, br. 1, str. 29-36
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Sinteza i karakterizacija pH-osetljivih poliuretanskih hidrogelova modifikovanih saharidima - uticaj poliola, umreživača i kiselinskog produživača lanca
Synthesis and characterization of pH-sensitive saccharide modified Polyurethane hydrogels: Effect of polyol, crosslinker and acid chain extender
aUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Prirodno-matematički fakultet + Univerzitet u Novom Sadu, Tehnološki fakultet bUniverzitet u Nišu, Tehnološki fakultet, Leskovac cUniverzitet u Novom Sadu, Tehnološki fakultet dUniverzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča eUniverzitet u Prištini sa privremenim sedištem u Kosovskoj Mitrovici, Prirodno-matematički fakultet
e-adresa: marija.kostic@pr.ac.rs
Projekat: Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (institucija: Univerzitet u Nišu, Tehnološki fakultet, Leskovac) (MPNTR - 451-03-68/2020-14/200133)
Ključne reči: poliuretani; pH-osetljivost; saharidi; nosači terapeutskih sredstava
Keywords: polyurethane; pH sensitivity saccharide; drug delivery system
Sažetak
Na biorazgradivim poliuretanima mogu se zasnivati sistemi za isporuku lekova osetljivi na spoljašnje promene. pH osetljivi poliuretani uspešno se koriste kao intravaginalni prstenovi i specifični sistemi za isporuku lekova za debelo crevo. U ovom radu izvršena je sinteza serije pH-osetljivih poliuretnaskih hidrogelova uz promenu poliolne komponente (poli(etilen-glikol) 400/poli(propilen-glikol) 2000/poli(etilen glikol)-blok-poli(propilen glikol)-blok-poli(etilen glikol) 1100), saharida kao umreživača (melibioza/rafinoza/skrob) i a-hidroksi karboksilnih kiselina kao produživača lanca (dimetilol propionska kiselina/mlečna kiselina). Strukturna karakterizacija sintetisanih poliretanskih hidrogelova vršena je pomoću infracrvene spektroskopije sa Furijeovom transformacijom (FTIR), čime je pokazano da je postignuta reakcija sinteze poliuretana uz uspešno umrežavanje saharidima i da su, uprkos menjanju polaznih komponenti, dobijeni FTIR spektri skoro identični. Stepen bubrenja hidrogelova posmatran je na 25 °C u rastvorima čije su pH vrednosti 4,5 i 7,4. Kod uzoraka sa poliolnom komponentom blok1100 stepen bubrenja u rastvoru pri pH 7,4 (16,09%) bio je i do 9 puta veći nego u rastvoru pri pH 4,5 (1,82%). Uticaji promenjivih parametara na termička svojstva i fazne prelaze PU hidrogelova ispitivani su termogravimetrijskom analizom (TGA) i diferencijalnom skenirajućom kalorimetrijom (DSC). Rezultati su pokazali da variranjem šećerne komponente kao umreživača, kiselinskog produživača lanca i dužine lanaca upotrebljenih poliola može se uticati na navedena svojstva poliuretanskih hidrogelova kao potencijalnih nosača terapeutskih sredstava.
Abstract
Biodegradable polyurethanes can be the basis for drug delivery systems that are sensitive to external changes. pH-sensitive polyurethanes (PUs) have been used successfully as intravaginal rings and specific drug delivery systems for the colon. In this study, a series of pH-sensitive polyurethane hydrogels with a change of the polyol component (poly(ethylene glycol) 400/poly(propylene glycol) 2000/poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) 1100), saccharides as crosslinkers (melibiose/raffinose/starch) and a-hydroxy carboxylic acids as chain extenders (dimethylol propionic acid/lactic acid) were synthesized. Structural characterization of the synthesized polyurethane hydrogels was performed using Fourier transform infrared spectroscopy (FTIR), which showed that the polyurethane synthesis reaction was achieved with successful crosslinking with saccharides and, despite the change of starting components, FTIR spectra for all investigated samples are almost identical. The degree of swelling of the hydrogels was monitored at 25 °C in solutions of pH values 4.5 and 7.4. In samples with the polyol component block1100, the degree of swelling at pH 7.4 (16.09%) was up to 9 times higher than at pH 4.5 (1.82%). The effects of variable parameters on the thermal properties and phase transitions of PUs hydrogels were investigated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that by varying the saccharide as a crosslinker, the acid chain extender and the chain length of the polyols, the stated properties of polyurethane hydrogels as potential drug delivery carriers can be influenced.
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Reference
|
|
 
|
Bhattacharyya, A., Mukhopadhyay, P., Kundu, P.P. (2014) Synthesis of a Novel pH-Sensitive Polyurethane-Alginate Blend with Poly(ethylene terephthalate) Waste for the Oral Delivery of Protein. Journal of Applied Polymer Science, 16: 131-142
|
|
|
Cherng, J.Y., Hou, T.Y., Shih, M.F., Talsma, H., Hennink, W.E. (2013) Polyurethane-based drug delivery systems. International Journal of Pharmaceutics, 450(1-2): 145-162
|
|
|
Clark, M.R., Johnson, T.J., McCabe, R., Clark, J.T., Tuitupou, A., Elgendy, H. (2012) A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781. J Pharm Sci, 101 (2014) 2012-2014
|
|
|
Dayananda, K., He, C., Lee, D.S. (2008) In situ gelling aqueous solutions of pHand temperature-sensitive poly(ester amino urethane)s. Polymer, 49(21): 4620-4625
|
|
|
Desai, S., Thakore, I.M., Sarawade, B.D., Devi, S. (2000) Effect of polyols and diisocyanates on thermo-mechanical and morphological properties of polyurethanes. European Polymer Journal, 36(4): 711-725
|
|
|
EDMQ (2010) European Pharmacopeia. Strasbourg: Council Of Europe-European Directorate for the Quality of Medicines and Healthcare, 7th ed., p. 430-431
|
|
|
Gopalakrishnan, S., Fernando, L.T. (2012) Influence of polyols on properties of bio-based polyurethanes. Bulletin of Materials Science, 35(2): 243-251
|
|
|
Lalwani, R., Desai, S. (2010) Sorption behavior of biodegradable polyurethanes with carbohydrate crosslinkers. Journal of Applied Polymer Science, 115(3): 1296-1305
|
|
|
Lu, Q.W., Hoye, T.R., Macosko, C.W. (2002) Reactivity of common functional groups with urethanes: Models for reactive compatibilization of thermoplastic polyurethane blends. Journal of Polymer Science Part A: Polymer Chemistry, 40(14): 2310-2328
|
|
|
Mahkam, M., Allahverdipoor, M. (2004) Controlled release of biomolecules from pH-sensitive network polymers prepared by radiation polymerization. Journal of Drug Targeting, 12(3): 151-156
|
|
|
Naeem, M., Kim, W., Cao, J., Jung, Y., Yoo, J. (2014) Enzyme/pH dual sensitive polymeric nanoparticles for targeted drug delivery to the inflamed colon. Colloids and Surfaces B: Biointerfaces, 123: 271-278
|
|
1
|
Park, J. (2016) Preparation and characterization of hydrogels using biopolymers. Journal of Material Science and Engineering, 05(10): 10-48
|
|
|
Reddy, T.T., Kano, A., Maruyama, A., Takahara, A. (2010) Synthesis, Characterization and Drug Release of Biocompatible/Biodegradable Non-toxic Poly(urethane urea)s Based on Poly(e-caprolactone)s and Lysine-Based Diisocyanate. Journal of Biomaterials Science, Polymer Edition, 21(11): 1483-1502
|
|
|
Rueda-Larraz, L., D'arlas, B., Tercjak, A., Ribes, A., Mondragon, I., Eceiza, A. (2009) Synthesis and microstructure-mechanical property relationships of segmented polyurethanes based on a PCL-PTHF-PCL block copolymer as soft segment. European Polymer Journal, 45(7): 2096-2109
|
|
|
Solanki, A., Mehta, J., Thakore, S. (2014) Structure-property relationships and biocompatibility of carbohydrate crosslinked polyurethanes. Carbohydrate Polymers, 110: 338-344
|
|
|
Solanki, A., Sanghvi, S., Devkar, R., Thakore, S. (2016) B-Cyclodextrin based magnetic nanoconjugates for targeted drug delivery in cancer therapy. RSC Advances, 6(101): 98693-98707
|
|
|
Solanki, A., Thakore, S. (2015) Cellulose crosslinked pH-responsive polyurethanes for drug delivery: A-hydroxy acids as drug release modifiers. International Journal of Biological Macromolecules, 80: 683-691
|
|
|
Solanki, A.R., Kamath, B.V., Thakore, S. (2015) Carbohydrate crosslinked biocompatible polyurethanes: Synthesis, characterization, and drug delivery studies. Journal of Applied Polymer Science, 42223(132): 1-12
|
|
|
Sun, X., Wang, H., Jing, Z., Mohanathas, R. (2013) Hemicellulose-based pH-sensitive and biodegradable hydrogel for controlled drug delivery. Carbohydrate Polymers, 92(2): 1357-1366
|
|
|
Swann, J.M.G., Bras, W., Topham, P.D., Howse, J.R., Ryan, A.J. (2010) Effect of the Hofmeister anions upon the swelling of a self-assembled pH-responsive hydrogel. Langmuir, 26(12): 10191-10197
|
|
|
Valodkar, M., Thakore, S. (2010) Isocyanate crosslinked reactive starch nanoparticles for thermo-responsive conducting applications. Carbohydrate Research, 345(16): 2354-2360
|
|
|
Xue, W., Champ, S., Huglin, M.B. (2001) Network and swelling parameters of chemically crosslinked thermoreversible hydrogels. Polymer, 42(8): 3665-3669
|
|
|
Yamaoka, T., Makita, Y., Sasatani, H., Kim, S.I., Kimura, Y. (2000) Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: Its properties, degradation behavior, and utilization for drug formulation. Journal of Controlled Release, 66(2-3): 187-197
|
|
|
|
|