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Journal of Medical Biochemistry
2018, vol. 37, br. 4, str. 456-464
Koncentracija srumskog hepcidina kao indikatora rezervi gvožđa u dece
Ćulafić Jelenaa, Kolarović Jovankaa, Pezo Latob ORCID, Čabarkapa Veliborc ORCID, Nikolić Stanislava c, Stojadinović Aleksandraa, Bodroža-Solarov Marijad ORCID
aUniverzitet u Novom Sadu, Medicinski fakultet
bInstitut za opštu i fizičku hemiju, Beograd
cUniverzitet u Novom Sadu, Medicinski fakultet + Klinički centar Vojvodine, Centar za laboratorijsku medicinu, Novi Sad
dInstitut za prehrambene tehnologije, Novi Sad

e-adresa: jovanka.kolarovic@mf.uns.ac.rs
Projekat:
Novi proizvodi cerealija i pseudocerealija iz organske proizvodnje (MPNTR - 46005)

Sažetak
Uvod: Anemija predstavlja značajan uzrok maternalnog i perinatalnog mortaliteta, kao i moratliteta dece. Cilj istraživanja je bio da se odredi serumska koncentracija hepcidina u dece uzrasta od 6 meseci do 2 godine i adolescenata uzrasta od 11 do 19 godina koji boluju od sideropenijske anemije i uporedi sa serumskom koncentracijom hepcidina u kontrolnim grupama, kao i da se odredi njegova povezanost sa parametrima koji ukazuju na metabolizam gvožđa. Metode: Istraživanjem je obuhvaćeno 173 ispitanika, 89 ispitanika koji su bolovali od sideropenijske anemije i 84 koji nisu bolovali od sideropenijske anemije (koji su predstavljali kontrolnu grupu). Krv je uzorkovana svim ispitanicima. Iz uzoraka je određivana kompletna krvna slika i vrednosti parametara metabolizma gvožđa. Nivo hepcidina u serumu je određivan ELISA metodom. Rezultati: Istraživanjem je pokazano da je koncentracija hepcidina statistički značajno niža kod dece (4,4 ng/mL) i adolescenata (4,1 ng/mL) koji boluju od sideropenijske anemije u poređenju sa kontrolnom grupom (14 ng/mL, odnosno 10 ng/mL, po redosledu navođenja). Potvrđena je pozitivna korelacija između koncentracije hepcidina i gvožđa u serumu, feritina, srednjeg volumena eritrocita i saturacije transferina, a negativna između nivoa hepcidina i transferina, kao i retikulocita. Zaključak: Uzrast ispitanika ne utiče na koncentraciju hepcidina u serumu što ga čini senzitivnijim pokazateljem nivoa gvožđa u organizmu. Osim toga, vrednost hepcidina u serumu predstavlja pouzdan biološki marker u postavljanju dijagnoze sideropenijske anemije.
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O članku

jezik rada: engleski
vrsta rada: izvorni članak
PMC ID: PMC6298481
DOI: 10.2478/jomb-2018-0003
objavljen u SCIndeksu: 04.02.2020.

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