Tobacco use and exposure to tobacco smoke is a threat to young people, who do not associate the experience of smoking with addiction and smoking habits of their parents accept as normal and expected behaviour. The aim of the research was to study the prevalence of cigarette smoking among children in higher grades of elementary schools in the municipality of Indjija as well as the family influence on their start of cigarette smoking and on their knowledge of tobacco threats. The research, in the form of cross-sectional study, was conducted among the pupils of higher grades of three elementary schools, during February and March 2014. Data collection was done by a modified form of the Global Youth Tobacco Survey. The study comprised 839 patients, aging 10-15, 53.4% male and 46.6% female. 7.5% of examinees had tried cigarettes, with a statistically significant difference among males (66.7%) and females (33.3%). A large number of the examinees tried a cigarette under the influence of family members (31.7%). 3.82% of the examinees continued cigarette smoking and 66% of them were exposed to tobacco smoke at their homes. 41.2% of the adolescents learned about the harmful effects of tobacco from their family members. The prevalence of smoking in the group 10-15 years of age in Indjija was lower as compared to the results of an earlier research conducted in the territory of Serbia. Preventive measures for the population of adolescents should be regular, organised and include both individual and group work which would continuously lead to the improvement of health and reduction of the disease.