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2020, vol. 148, br. 11-12, str. 732-736
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Status p16 skvamocelularnih karcinoma orofarinksa i usne duplje - iskustvo naše institucije
p16 status of oropharyngeal and oral cavity squamous cell carcinomas: A single institution experience
Tomanović Nadaa, Tomić Anamarijaa, Boričić Ivana, Milovanović Jovicab  , Folić Miljanb , Krejović-Trivić Sanjab, Miković Nikolac, Đorić Igord, Parapid Biljanae , Uskoković Nikolaf, Trivić Aleksandarb
aUniverzitet u Beogradu, Medicinski fakultet, Institut za patološku anatomiju, Srbija bUniverzitet u Beogradu, Medicinski fakultet, Klinički centar Srbije, Klinika za otorinolaringologiju i maksilofacijalnu hirurgiju, Beograd cUniverzitet u Beogradu, Stomatološki fakultet, Klinika za maksilofacijalnu hirurgiju, Srbija dKlinički centar Srbije, Centar za radiologiju i magnetnu rezonancu, Beograd, Srbija eKlinički centar Srbije, Klinika za kardiologiju, Beograd, Srbija fInstitut za javno zdravlje Kragujevac, Centar za kontrolu i prevenciju bolesti, Kragujevac
e-adresa: drcole71.at@gmail.com
Projekat: Molekulski prognostički markeri i epigenetska kontrola u tumorima kože i regije glave i vrata (MPNTR - 175026)
Sažetak
Uvod/Cilj Nova klasifikacija tumora glave i vrata Svetske zdravstvene organizacije iz 2017. godine unela je značajne promene, uglavnom vezane za regiju orofarinksa. Uvedeni su novi entiteti HPV pozitivnih i negativnih skvamocelularnih karcinoma, ne samo na osnovu prisustva aktivne virusne infekcije i ekspresije različitih tumorskih markera već i zbog svoje različite histopatologije, procene stadijuma bolesti i prognoze. Sprovedena je retrospektivna studija sa ciljem da se odredi p16 pozitivnost u skvamocelularnim karcinomima orofarinksa i usne šupljine, kao i kako bi se utvrdilo da li postoji razlika među različitim polovima i starosnim grupama. Metode Prisustvo virusne infekcije je potvrđivano na osnovu imunohistohemijske analize na p16, koji je marker za infekciju humanim virusom papiloma. Uvidom u arhivu Patohistološke laboratorije Klinike za otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Srbije pregledano je 177 slučajeva skvamocelularnih karcinoma orofarinksa i usne šupljine. Rezultati Od 177 slučajeva, 50 (28,2%) slučajeva je bilo p16 pozitivno. U poređenju sa karcinomima usne šupljine, karcinomi p16 su bili značajno češći u orofarinksu (34,3% u orofarinksu u poređenju sa 10,3% u usnoj šupljini). Karcinomi u obe regije su bili češći kod pripadnika muškog pola (88,1% svih slučajeva bili su muškog pola), ali je p16 pozitivnost bila znatno češća kod ženskih bolesnika (11 od 21 slučaja, 52,4%). Najčešća lokalizacija p16 pozitivnih karcinoma bili su nepčani krajnici (41,03% karcinoma krajnika bilo je p16 pozitivno). Zaključak p16 pozitivni skvamocelularni karcinomi bili su najbrojniji u orofarinksu (tačnije u nepčanim krajnicima) i češći su bili kod ženskog pola.
Abstract
Introduction/Objective New World Health Organization Classification of Head and Neck Tumors from 2017 has introduced significant changes, mainly considering tumors in the oropharyngeal region. New entities of HPV-positive and -negative squamous cell carcinomas have been acknowledged, not only based on the presence of an active viral infection and different tumor markers expression, but also because of their different histopathology, staging assessment, and prognosis. A retrospective study has been conducted, in order to determine p16 positivity in squamous cell carcinomas in oropharynx and in the oral cavity, and to see whether they differ in sex and age distribution. Methods The presence of viral infection was verified based on p16 immunochemistry staining, p16 being the surrogate marker for HPV infection. A total of 177 cases of squamous cell carcinomas in the oropharynx and the oral cavity, found in the archives of the Histopathology Laboratory of the Clinic for Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, have been revised. Results Out of 177 cases, 50 (28.2%) were p16-positive. Compared with carcinomas in the oral cavity, p16 carcinomas were significantly more common in the oropharynx (34.3% in the oropharynx, compared to 10.3% in the oral cavity). Carcinomas in both regions were mostly associated with male sex (88.1% of all cases were in males), but p16 positivity was more common in females (11 out of 21 cases, 52.4%). The most common location of p16-positive carcinomas were palatine tonsils (41.03% of tonsillar carcinomas were p16-positive). Conclusion P16-positive squamous cell carcinomas were the most numerous in the oropharynx, i.e. palatine tonsils, and were more common in females.
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