Metrics

  • citations in SCIndeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[]
  • visits in previous 30 days:1
  • full-text downloads in 30 days:0

Contents

article: 4 from 14  
Back back to result list
2011, vol. 68, iss. 12, pp. 1021-1025
Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children
aUniveristy of Niš, Faculty of Medicine, Clinic of Stomatology
bUniveristy of Niš, Faculty of Medicine, Department of Pathology
cUniversity of Belgrade, Faculty of Dental Medicine

emailigicmarija@gmail.com
Abstract
Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect.
References
Anuradha, A., Sivapathasundharam, B. (2007) Image analysis of normal exfoliated gingival cells. Indian journal of dental research, 18(2): 63-6
Bartold, P.M. (1993) Platelet-derived growth factor stimulates hyaluronate but not proteoglycan synthesis by human gingival fibroblasts in vitro. Journal of dental research, 72(11): 1473-80
Dibart, S. (1997) Children, adolescents and periodontal diseases. J Dent, 25(2): 79-89
Feres, M., Haffajee, A.D., Allard, K., Som, S., Socransky, S.S. (2001) Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. J Clin Periodontol, 28(7): 597-609
Giannobile, W.V., Riviere, G.R., Gorski, J.P., Tira, D.E., Cobb, C.M. (1993) Glycosaminoglycans and periodontal disease: analysis of GCF by safranin O. Journal of periodontology, 64(3): 186-90
Grundemann, L.J., Timmerman, M.F., Ijzerman, Y., Weijden, G.A., Weijden, G.A. (2000) Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate. J Clin Periodontol, 27(1): 9-15
Irwin, C.R., Schor, S.L., Ferguson, M.W. (1994) Effects of cytokines on gingival fibroblasts in vitro are modulated by the extracellular matrix. Journal of periodontal research, 29(5): 309-17
Jentsch, H., Pomowski, R., Kundt, G., Göcke, R. (2003) Treatment of gingivitis with hyaluronan. Journal of clinical periodontology, 30(2): 159-64
Mesa, F.L., Aneiros, J., Cabrera, A., Bravo, M., Caballero, T., Revelles, F., Moral, R.G., Valle, O.F. (2002) Antiproliferative effect of topic hyaluronic acid gel. Study in gingival biopsies of patients with periodontal disease. Histology and histopathology, 17(3): 747-53
Modeer, T., Wondimu, B. (2000) Periodontal diseases in children and adolescents. Dent Clin North Am, 44(3): 633-58
Moseley, R., Waddington, R.J., Embery, G. (2002) Hyaluronan and its potential role in periodontal healing. Dental update, 29(3): 144-8
Oh, T., Eber, R., Wang, H. (2002) Periodontal diseases in the child and adolescent. J Clin Periodontol, 29(5): 400-10
Oksala, O., Salo, T., Tammi, R., Häkkinen, L., Jalkanen, M., Inki, P., Larjava, H. (1995) Expression of proteoglycans and hyaluronan during wound healing. Journal of histochemistry and cytochemistry, 43(2): 125-35
Pagnacco, O., Vangelisti, R., Erra, C., Poma, A. (1997) Double-blind clinical trial vs. Placebo of a new sodium-hyaluronate-based gingival gel. Transl Attualita Terapeutica Int, 4, str. 1-12
Pistorius, A., Rockmann, P., Martin, M., Willershausen, B. (2005) The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int, 36(7-8), str. 531-8
Rams, T.E., Listgarten, M.A., Slots, J. (1996) Utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in patients on maintenance care. J Clin Periodontol, 23(4): 346-54
Vangelisti, R., Pagnacco, O., Erra, C. (1997) Hyaluronic acid in the topical treatment of gingival inflammations: preliminary clinical trial. Transl Attualita Terapeutica Int, 3, str. 1-7
 

About

article language: Serbian
document type: Original Paper
DOI: 10.2298/VSP1112021I
published in SCIndeks: 20/12/2011
peer review method: double-blind

Related records

No related records