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2011, vol. 58, iss. 2, pp. 67-74
Moleculobiological characteristics of oral squamous cell carcinomas
aUniversity of Belgrade, Institute for Biological Research 'Siniša Stanković'
bUniversity of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča
cUniversity of Belgrade, Faculty of Dental Medicine
dClinical Centre 'Zvezdara', Belgrade

emailjelena_milasin@yahoo.com
Project:
Genetic control and molecular mechanisms in malignant, inflammatory and developmental pathologies of the orofacial region (MESTD - 175075)

Keywords: oral carcinomas; carcinogenic genes; viral infections; hipermethylation; predisposition
Abstract
Oral squamous cell carcinomas (OSCCs) are associated with poor prognosis, and despite advances in therapy approaches, no major improvement in survival has been achieved in the recent years. Efforts are now directed toward finding new biological markers that could predict tumor behavior more accurately. OSCCs, as the majority of malignant tumors, arise from progressive accumulation of genetic and epigenetic lesions, transforming normal cells into malignant. In this paper, an analysis of current studies directed to understanding the underlying mechanisms of OSCC pathogenesis was presented. The emphasis was put on mutational analysis of cancer genes, as well as on the role of viral infections and methylation processes in OSCC. Finally, an overview of studies that tried to determine the possibility for developing OSCC was given.
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article language: English, Serbian
document type: Review Paper
DOI: 10.2298/SGS1102067T
published in SCIndeks: 07/09/2011

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