Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:1
  • preuzimanja u poslednjih 30 dana:0

Sadržaj

članak: 10 od 14  
Back povratak na rezultate
2008, vol. 65, br. 8, str. 633-638
Grejvs-Bazedovljeva bolest i potencijalni faktori rizika
aZdravstveni centar, Odeljenje ginekologije i akušerstva, Ćuprija
bUniverzitet u Beogradu, Medicinski fakultet, Institut za epidemiologiju
cUniverzitet u Beogradu, Biološki fakultet
dUniverzitet u Beogradu, Stomatološki fakultet

e-adresasandragru@ptt.yu
Ključne reči: gušavost; egzoftalmička; faktori rizika; zdravlje; porodično; Srbija
Sažetak
Uvod/Cilj. Grejvs-Bazedovljeva bolest nastaje kao rezultat interakcije između genetičkih faktora i faktora sredine. Cilj ovog rada bio je da se ispita prisustvo faktora rizika koji mogu da utiču na nastajanje Grejvs-Bazedovljeve bolesti kod populacije Pomoravskog okruga, kao i da se ispita da li postoji razlika u prisutnim faktorima rizika između obolelih od Grejvs- Bazedovljeve bolesti sa i bez pozitivne porodične anamneze ovog oboljenja. Metode. U studiju je bilo uključeno 350 osoba Pomoravskog okruga, od kojih je 132 bilo sa Grejvs- Bazedovljevom bolešću i 130 zdravih osoba, za koje je utvrđeno da nemaju endokrinološko oboljenje. U cilju procene izloženosti potencijalnim faktorima rizika od nastajanja Grejvs-Bazedovljeve bolesti koristili smo upitnik koji je sadržao pitanja koja su se odnosila na demografske karakteristike, pušenje, stres, izloženost hemijskim i fizičkim agensima na poslu i prisustvo pozitivne porodične anamneze Grejvs- Bazedovljeve bolesti za period pre dijagnostikovanja oboljenja. Rezultati. Osobe sa Grejvs-Bazedovljevom bolešću, u poređenju sa osobama bez Grejvs-Bazedovljeve bolesti, značajno češće bile su: starijeg uzrasta (50 i više godina) (p = 0,020), izložene stresu (p = 0,024) i fizičkim agensima na poslu (p = 0,031), sa pozitivnom porodičnom anamnezom Grejvs-Bazedovljeve bolesti i sa većim brojem prvo- i drugostepenih srodnika sa istim oboljenjem (p = 0,000). Oboleli od Grejvs-Bazedovljeve bolesti sa pozitivnom porodičnom anamnezom, nisu se statistički značajno razlikovali po izloženosti potencijalnim faktorima rizika u odnosu na obolele osobe bez pozitivne porodične anamneze Grejvs-Bazedovljeve bolesti, sem što su značajno češće u ovoj grupi bile žene (p = 0,000). Zaključak. Pol, uzrast, pozitivna porodična anamneza Grejvs-Bazedovljeve bolesti i izloženost fizičkim agensima identifikovani su kao potencijalni faktori rizika od Grejvs- Bazedovljeve bolesti. Različiti faktori rizika verovatno su odgovorni za nastanak Grejvs-Bazedovljeve bolesti kod obolelih osoba sa i bez pozitivne porodične istorije ovog oboljenja.
Reference
Barclay, M.L., Brownlie, B.E., Turner, J.G., Wells, J.E. (1994) Lithium associated thyrotoxicosis: A report of 14 cases, with statistical analysis of incidence. Clin Endocrinol, 40(6): 759-64
Bolacos, F., Figueroa, F., Castro, E. (1996) A case of posterior thyroid ophthalmopathy following neck irradiation. Rev Invest Clin, 48(6): 457-9
Boukis, M.A., Koutras, D.A., Souvatzoglou, A., Evangelopoulou, A., Vrontakis, M., Moulopoulos, S.D. (1983) Thyroid hormone and immunological studies in endemic goiter. J Clin Endocrinol Metab, 57(4): 859-62
Brix, T.H., Kyvik, K.O., Christensen, K., Hegedus, L. (2001) Evidence for a major role of heredity in Graves' disease: A population-based study of two Danish twin cohorts. J Clin Endocrinol Metab, 86(2): 930-4
Chen, Q.Y., Huang, W., She, J.X., Baxter, F., Volpe, R., Maclaren, N.K. (1999) HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective. J Clin Endocrinol Metab, 84(9): 3182-6
Chiovato, L., Pinchera, A. (1996) Stressful life events and Graves' disease. Eur J Endocrinol, 134(6): 680-2
Christensen, S.B., Ericsson, U.B., Janzon, L., Tibblin, S., Melander, A. (1984) Influence of cigarette smoking on goiter formation, thyroglobulin, and thyroid hormone levels in women. J Clin Endocrinol Metab, 58(4): 615-8
Corenblum, B., Adediji, O.S., Killian, P. (2007) Goiter, diffuse toxic. u: Gambert S.R., Talavera F., Shenker Y., Cooper M., Griffing G.T. [ur.] Endocrinology, e-Medicine, Sept 12, Available from: http://www. e
de Groot, L.J. (2003) Graves disease and the manifestations of thyrotoxicosis. u: Dumont J.E., Corvilain B., Maenhaut C., Rousset B.A., Dunn J.T., Rafetoff S., i dr. [ur.] Thyroid disease manager, Chapter 10: Endocrine education, Chicago: Endocrine education
Eng, T.Y., Boersma, M.K., Fuller, C.D., i dr. (2006) The role of radiation therapy in benign diseases. Hematology/Oncology Clinics of North America, 20(2): 523
Grammaticos, P., Vasiliou, O., Papanastasiou, E., Gerasimou, G., Balaris, V., Alexandris, R., i dr. (2006) The clinical and laboratory findings in Graves' multinodular type disease. Hell J Nucl Med, 9(1), str. 53-9
Harris, T., Creed, F., Brugha, T.S. (1992) Stressful life events and Graves' disease. Br J Psychiatry, 161: 535-41
Hegedius, L., Brix, T.H., Vestergaard, P. (2004) Relationship between cigarette smoking and Graves' ophthalmopathy. J Endocrinol Invest, 27(3): 265-71
Holm, I.A., Manson, J.E., Michels, K.B., Alexander, E.K., Willett, W.C., Utiger, R.D. (2005) Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism. Arch Intern Med, 165(14): 1606-11
Imaizumi, M., Usa, T., Tominaga, T., i dr. (2006) Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in hiroshima and nagasaki atomic bomb survivors 55-58 years after radiation exposure. JAMA, 295(9): 1011
Iversen, K. (1948) Temporary rise in the frequency of thyrotoxicosis in Denmark, 1941-1945. Copenhagen: Rosenkilde and Bagger
Janković, S.M., Radosavljević, V.R., Marinković, J.M. (1997) Risk factors for Graves' disease. Eur J Epidemiol, 13(1): 15-8
Krassas, G.E., Wiersinga, W. (2006) Smoking and autoimmune thyroid disease: The plot thickens. European Journal of Endocrinology, 154(6): 777
Kula, D., Bednarczuk, T., Jurecka-Lubieniecka, B., Polanska, J., Hasse-Lazar, K., Jarzab, M. (2006) Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: The impact of DRB1*07. Thyroid, 16(5): 447
Kumorowicz-Kopiec, M., Dziatkowiak, H., Starzyk, J., Nizankowska-Blaz, T., Rybakowa, M. (2004) Incidence of Graves disease in children in some regions of south-eastern Poland. Przegl Lek, 61(8): 872-5
Kung, A.W. (1995) Life events, daily stresses and coping in patients with Graves' disease. Clin Endocrinol (Oxf), 42(3): 303-8
Lind, P., Langsteger, W., Molnar, M., Gallowitsch, H.J., Mikosch, P., Gomez, I. (1998) Epidemiology of thyroid diseases in iodine sufficiency. Thyroid, 8(12): 1179-83
Manji, N., Carr-Smith, J.D., Boelaert, K., Allahabadia, A., Armitage, M., Chatterjee, V.K. (2006) Influences of age, gender, smoking and family history on autoimmune thyroid disease phenotype. Journal of Clinical Endocrinology and Metabolism, 91(12): 4873
Marganti, S., Ceda, G.P., Saccani, M., i dr. (2005) Thyroid disease in the elderly: Sex-related differences in clinical expression. J Endocrinol Invest, 28(Suppl 11 Proceedings): 101-4
Matos-Santos, A., Nobre, E.L., Costa, J.G., Nogueira, P.J., Macedo, A., Galvgo-Teles, A., Castro, J.J. (2001) Relationship between the number and impact of stressful life events and the onset of Graves' disease and toxic nodular goitre. Clin Endocrinol (Oxf), 55(1): 15-9
Mizokami, T., Wu, L.A., El-Kaissi, S., Wall, J.R. (2004) Stress and thyroid autoimmunity. Thyroid, 14(12): 1047-55
Nakamura, S., Kajita, Y., Ochi, Y. (2000) Familial dysalbuminemic hypertriiodothyroninemia in a Japanese kindred. Intern Med, 39(1): 50-4
Philippou, G., Krimitzas, A., Kaltsas, G., Anastasiou, E., Souvatzoglou, A., Alevizaki, M. (2001) HLA DQA1*0501 and DRB1*0301 antigens do not independently convey susceptibility to Graves' disease. J Endocrinol Invest, 24(2): 88-91
Prummel, M.F., Wiersinga, W.M. (1993) Smoking and risk of Graves' disease. JAMA, 269(4): 479-82
Prummel, M.F., Strieder, T., Wiersinga, W.M. (2004) The environment and autoimmune thyroid diseases. Eur J Endocrinol, 150(5): 605-18
Radosavljević, V.R., Janković, S.M., Marinković, J.M. (1996) Stressful life events in the pathogenesis of Graves' disease. Eur J Endocrinol, 134(6): 699-701
Rochman, H., de Groot, L.J., Rieger, C.H., Varnavides, L.A., Refetoff, S., Joung, J.I., Hoye, K. (1975) Carcinoembryonic antigen and humoral antibody response in patients with thyroid carcinoma. Cancer Res, 35(10): 2689-92
Vanderpump, M.P., Tunbridge, W.M., French, J.M., Appleton, D., Bates, D., Clark, F., Grimley, E.J., Hasan, D.M., Rodgers, H., Tunbridge, F. (1995) The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf), 43(1): 55-68
Vanderpump, P.J., Tunbridge, W.M.G. (1999) The epidemiology of autoimmune thyroid disease. u: Volpe P. [ur.] Autoimmune Endocrinopathies, Totowa, NJ: Humana Press, str. 141-142
Vermiglio, F., Castagna, M.G., Volnova, E., Lo, P.V.P., Moleti, M., Violi, M.A., Artemisia, A., Trimarchi, F. (1999) Post-Chernobyl increased prevalence of humoral thyroid autoimmunity in children and adolescents from a moderately iodine-deficient area in Russia. Thyroid, 9(8): 781-6
Volpre, R. (1990) Immunology of human thyroid disease. u: Volpe R. [ur.] Autoimmunity in endocrine disease, Boca Raton: CRC Press, 73-98
Weetman, A.P. (2000) Graves' disease. N Engl J Med, 343(17): 1236-48
Winsa, B., Adami, H.O., Bergstrom, R., Gamstedt, A., Dahlberg, P.A., Adamson, U., Jansson, R., Karlsson, A. (1991) Stressful life events and Graves' disease. Lancet, 338(8781): 1475-9
 

O članku

jezik rada: srpski
vrsta rada: originalan članak
DOI: 10.2298/VSP0808633Z
objavljen u SCIndeksu: 06.10.2008.

Povezani članci

Nema povezanih članaka