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Recirkulacija naivnih T limfocita
Dom zdravlja, Krupa na Uni, Republika Srpska

e-adresamarijanajandrickocic@gmail.com
Ključne reči: naivni T limfociti; primarni imunološki odgovor
Sažetak
Nakon razvoja u timusu, naivni T limfociti dospijevaju u cirkulaciju i kontinuirano recirkulišu između krvi i perifernih limfoidnih organa u cilju aktivacije i transformacije u efektorske ćelije. Kretanje naivnih T limfocita predstavlja uređen slijed kontrolisan ekspresijom specifičnih proteina (selektina, integrina i hemokina), koji uključuje regrutovanje cirkulišućih limfocita na luminalnoj površini krvnog suda, transendotelnu tranziciju, te migraciju unutarekstravaskularnog odeljka perifernih limfoidnih organa. Pitanje kretanja naivnih T limfocita u i iz nelimfoidnih organa u fiziološkim uslovima nije u potpunosti razriješeno. Postoji mišljenje da naivni T limfociti u fiziološkim uslovima rutinski pristupaju gotovo svim nelimfoidnim organima u svrhu imunološkog nadzora i/ili indukcije tolerancije. Nelimfoidni organi opterećeni hroničnom upalom i tumorskim procesom mogu posjedovati značajan broj naivnih T limfocita. Organizovano limfoidno tkivo uzročno doprinosi perzistenciji određenih autoimunih bolesti. Regrutacija u tumorskom tkivu i naknadni antitumorski imunološki odgovor korespondiraju sa pozitivnom prognozom.
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O članku

jezik rada: srpski, engleski
vrsta rada: neklasifikovan
DOI: 10.5937/mgiszm2286025J
objavljen u SCIndeksu: 24.09.2022.
Creative Commons License 4.0

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