• citations in SCIndeks: 0
  • citations in CrossRef:0
  • citations in Google Scholar:[]
  • visits in previous 30 days:0
  • full-text downloads in 30 days:0


article: 1 from 3  
Back back to result list
2011, vol. 50, iss. 4, pp. 35-39
Interaction of biomaterials containing calcium hydroxyapatite/poly-L-lactide with the simulated body fluid
aUniveristy of Niš, Faculty of Medicine, Institute of Biology and Human Genetics, Serbia
bUniveristy of Niš, Faculty of Medicine, Department of Pharmacy, Serbia
cUniveristy of Niš, Faculty of Medicine, Institute of Biomedical Research, Serbia
dSerbian Academy of Sciences and Arts - SASA, Institute of Technical Sciences , Belgrade, Serbia
eUniveristy of Niš, Faculty of Science, Department of Biology and Ecology, Serbia
Virtual human osteoarticular system and its application in preclinical and clinical practice (MESTD - 41017)

Keywords: biomaterials; HAp/PLLA; SBF; SEM; EDS
The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.
Angelova, N., Hunkeler, D. (1999) Rationalizing the design of polymeric biomaterials. Trends Biotechnol, 17(10): 409-21
Hench, L.L., Etheridge, E.C. (1982) Biomaterials: An interfacial approach. New York: Academic Press
Ignjatović, N.L., Plavšić, M.B., Uskoković, D.P. (2000) Hydroxyapatite/poly-L-lactide (collagen) biocomposite with poly-L-lactide of different molecular weights. Advanced Engineering Materials, vol. 2, br. 8, str. 511-514
Ignjatović, N.L., Tomić, S., Dakić, M., Miljković, M., Plavšić, M., Uskoković, D. (1999) Synthesis and properties of hydroxyapatite/poly-L-lactide composite biomaterials. Biomaterials, 20(9): 809-16
Ignjatović, N.L., Plavšić, M., Miljković, M.S., Živković, Lj.M., Uskoković, D.P. (1999) Microstructural characteristics of calcium hydroxyapatite/poly-L-lactide based composites. J Microsc, 196(Pt 2): 243-8
Ignjatović, N.L., Savić, V., Najman, S., Plavšić, M., Uskoković, D. (2001) A study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy. Biomaterials, vol. 22, br. 6, str. 571-575
Kokubo, T. (1996) Formation of biologically active bone-like apatite on metals and polymers by a biomimetic process. Thermochimica Acta, 280-281, 479-90
Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T., Yamamuro, T. (1990) Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. Journal of biomedical materials research, 24(6): 721-34
Kurashina, K., Kurita, H., Takeuchi, H., Hirano, M., Klein, C.P., de Groot, K. (1995) Osteogenesis in muscle with composite graft of hydroxyapatite and autogenous calvarial periosteum: A preliminary report. Biomaterials, 16(2): 119-23
Mucalo, M.R., Toriyama, M., Yokogawa, Y., Suzuki, T., Kawamoto, Y., Nagata, F., Nishizawa, K. (1995) Growth of calcium phosphate on ion-exchange resins pre-saturated with calcium or hydrogen phosphate ions: an SEM/EDX and XPS study. Journal of Materials Science: Materials in Medicine, 6(7), 409-19
Murphy, W.L., Kohn, D.H., Mooney, D.J. (2000) Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. Journal of biomedical materials research, 50(1): 50-8
Ripamonti, U., Duneas, N. (1996) Tissue engineering of bone by osteoinductive biomaterials. RS Bulletin, 21, str. 36-39
Rodrigez-Lorenco, L., Salinas, A., Vallet-Regi, M., san Roman, J. (1996) Composite biomaterials based on ceramic polymers. I. Reinforced systems based on Al2O3/PMMA/PLLA. J Biomed Mater Res, 30(4): 515-22
Södergård, A., Stolt, M. (2002) Properties of lactic acid based polymers and their correlation with composition. Progress in Polymer Science, 27(6): 1123
Takadama, H., Kim, H., Kokubo, T., Nakamura, T. (2002) X-ray photoelectron spectroscopy study on the process of apatite formation on a sodium silicate glass in simulated body fluid. Journal of the American Ceramic Society, 85(8), 1933-1936
Vasiljević, P.J., Najman, S.J., Đorđević, L.B., Savić, V.P., Vukelić, M.Đ., Živanov-Čurlis, J.Z., Ignjatović, N.L., Uskoković, D.P. (2009) Ektopična osteogeneza i hematopoeza iz implantiranih ćelija koštane srži na matrici od biokompozita HAP/PLLA. Hemijska industrija, vol. 63, br. 4, str. 301-307
Zhang, R., Ma, P.X. (1999) Porous poly(L-lactic acid)/apatite composites created by biomimetic process. Journal of biomedical materials research, 45(4): 285-93


article language: English
document type: Original Scientific Paper
published in SCIndeks: 20/03/2012

Related records

No related records