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2009, vol. 62, br. 7-8, str. 327-330
Imunomodulatorna delovanja antibiotika
aSpecijalistička ordinacija 'Dr Bojić', Beograd
bUniverzitet u Beogradu, Medicinski fakultet, KBC 'Dr Dragiša Mišović'
cKlinički centar Vojvodine, Klinika za infektivne bolesti, Novi Sad

e-adresadrbojic@net.yu
Sažetak
Interakcija antimikrobnih lekova i imunološkog sistema organizma se istražuje od pionirskih radova Metchnikoffa. Posle uvođenja antibiotika u kliničku praksu ovo područje je, zbog nedostatka standarda privlačilo malu pažnju istraživača. Zbog toga su proučavanja o uticaju antibiotika na imunološki sistem još u začetku. Cilj rada bio je da istakne imunomodulatorna delovanja nekih antibiotika prema pojedinim komponentama imunološkog sistema. Podaci iz literature pokazuju da antibiotici ispoljavaju imunomodulatorna delovanja prema pojedinim komponentama imunološkog sitema, kao što su: fagociti (polimorfonukleari, monociti, makrofagi), citokini, imunoglobulini i ćelijska imunost. Principi delovanja antibiotika na fagocite se sastoje u ihibiciji hemotakse i produkcije oksidanata. Makrolidni antibiotici primenjeni kratkotrajno pojačavaju fagocitne funkcije, dok duža primena ima za posledicu imunosupresiju. Neki cefalosporini i rifampicin u terapijskim koncentracijama izazivaju inihibiciju oksidativnog metabolizma monocita. Inhibiciju sinteze superoksidnih aniona izazivaju tetraciklini, klindamicin, hloramfenikol i tobramicin. Pored toga značaj- na su delovanja nekih antibiotika na produkciju citokina i specifičnih antitela. Ćelijska imunost takođe može da bude pogođena. Za uspostavljanje normalne ćelijske imunosti posle primene nekih antibiotika potrebno je 1-2 nedelje, a kod drugih i više nedelja. Još uvek nema jasnog stava o stvarnom učinku antibiotika na imunološki sistem. Kliničari treba da koriste više informacija iz ovog novog-starog polja istraživanja, kako bi bolesnicima pružili adekvatniju terapiju.
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O članku

jezik rada: srpski
vrsta rada: pregledni članak
DOI: 10.2298/MPNS0908327M
objavljen u SCIndeksu: 17.11.2009.

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