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Antimikrobna aktivnost metanolnih ekstrakata četiri vrste lišajeva iz porodice Parmeliaceae
aUniverzitet u Nišu, Medicinski fakultet, Katedra Farmacija
bUniverzitet u Nišu, Prirodno-matematički fakultet, Odsek Hemija
cUniverzitet u Nišu, Prirodno-matematički fakultet, Odsek Biologija i ekologija

e-adresaigor.pfc@hotmail.com
Projekat:
Dobijanje, fizičko-hemijska karakterizacija, analitika i biološka aktivnost farmakološki aktivnih supstanci (MPNTR - 172044)

Ključne reči: Hypogymnia physodes (L.) Nyl.; Evernia prunastri (L.) Ach.; Flavoparmelia caperata (L.) Hale; Parmelia sulcata Taylor; metanolni ekstrakt; antimikrobna aktivnost
Sažetak
U ovom radu je disk-difuzionom metodom (1 mg uzorka ekstrakta po disku; ekstrakti su rastvarani u metanolu; koncentracija je bila 25 mg/mL) određena antimikrobna aktivnost metanolnih ekstrakata četiri vrste lišaja iz porodice Parmeliaceae (Hypogymnia physodes (L.) Nyl., Evernia prunastri (L.) Ach., Flavoparmelia caperata (L.) Hale i Parmelia sulcata Taylor). Testirana je aktivnost na 11 sojeva Gram-pozitivnih (Enterococus sp., Bacillus subtilllis, Sarcina lutea, Micrococus luteus, Staphylococcus aureus, Clostridium sporogenes) i Gram-negativnih bakterija (Escherichia coli, Proteus vulgaris, Salmonela enteritidis, Pseudomonas aeruginosa, Klebsiella pneumoniae), i po jedna plesan (A. niger) i kvasac (C. albicans). Svi testirani ekstrakti su pokazali umerenu antimikrobnu aktivnost. Multivarijantna statistička analiza (aglomerativna hijerarhijska klaster analiza) dobijenih rezultata omogućila je da se testirani uzorci grupišu na osnovu sličnosti/razlika u pokazanoj antimikrobnoj aktivnosti prema različitim sojevima mikroorganizama: antimikrobni profili ekstrakata H. physodes i E. prunastri su bili uporedivi; slično važi za ekstrakte F. caperata i P. sulcata. Pored toga, na osnovu sličnosti/razlika u osetljivosti na dejstvo ekstrakata proučavanih lišajeva, ovde testirani mikroorganizmi se mogu podeliti u dve grupe: Grupa I - P. vulgaris, K. pneumoniae (Gram-negativne bakterije), A. niger i C. albicans; Grupa II - E. coli, S. enteritidis, P. aeruginosa (Gram-negativne bakterije) i sve ispitivane Gram-pozitivne vrste.
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