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Acta medica Medianae
2021, vol. 60, br. 2, str. 25-34
Značaj i potencijalna primena morfometrijske analize humanih glomerula u kadaveričnoj transplantaciji bubrega
Stojanović Vesnaa ORCID, Jovanović Ivana ORCID, Kundalić Bracaa ORCID, Ugrenović Slađanaa, Pavlović Miljanaa, Trandafilović Milenaa ORCID, Čukuranović Kokoris Jovanaa, Petrović Vladimirb ORCID
aUniverzitet u Nišu, Medicinski fakultet, Katedra Anatomija, Srbija
bUniverzitet u Nišu, Medicinski fakultet, Katedra Histologija sa embriologijom, Srbija

e-adresa: milena.trandafilovic@medfak.ni.ac.rs
Projekat:
Etiologija, dijagnostika, prevencija, i terapija endemske nefropatije i sa njom povezanih tumora urotela - značaj istraživanja genoma i proteoma (MPNTR - 175092)
Antioksidativna zaštita i potencijali za diferencijaciju i regeneraciju mezenhimalnih matičnih ćelija iz različitih tkiva tokom procesa starenja (MPNTR - 175061)
Proizvodnja novih dijetetskih mlečnih proizvoda za rizične populacije zasnovana na kvalitativnoj i kvantitativnoj analizi biohemijskih markera zdravstvenog rizika konzumiranja mleka (MPNTR - 31060)
Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (MPNTR - 41018)
This study was supported by the Internal projects of the Faculty of Medicine in Niš (No 38/20)

Ključne reči: ljudski glomeruli; transplantacija bubrega; morfometrija
Sažetak
Kadaverična transplantacija bubrega u stalnom je porastu, zbog smanjenog mortaliteta mlađih pojedinaca. Tokom procesa ovih transplantacija, od velike je važnosti odrediti ne samo starosnu granicu primaoca, već i status davaoca. Istraživanje je obuhvatilo 30 uzoraka tkiva ljudskih kadaveričnih bubrega (oba pola, starosti od 20 do 85 godina). Uzorci tkiva obojeni su Mallori trihromskim bojenjem i analizirani pod svetlosnim mikroskopom. Slike su analizirane pomoću softvera ImageJ. Kao rezultat klaster analize, 743 glomerula klasifikovana su u 3 grupe prema morfometrijskim karakteristikama i u 3 starosne grupe (I grupa prosečne starosti 29 godina, II grupa 44 godine, III grupa sa prosekom starosti 71 godina). U prvoj grupi po morfometrijskim karakteristikama bilo je 114 sklerotičnih glomerula sa značajno (p ≤ 0,0001) najmanjom površinom i calularnošću, a najvećim procentom vezivnog tkiva. U drugoj grupi bilo je 430 morfološki normalnih glomerula sa najvećim brojem ćelija po jedinici površine (p ≤ 0,0001). U trećoj grupi bilo je 199 hipertrofičnih glomerula sa najvećom površinom, značajno velikom calularnošću i površinom vezivnog tkiva (p ≤ 0,0001). Od 114 sklerotičnih glomerula najmanji broj pripada I starosnoj grupi (p ≤ 0,0001). Ukupno je bilo 430 morfološki normalnih glomerula. Većina morfološki normlanih glomerula bila je u II starosnoj grupi (p ≤ 0,0001). Većina od 199 hipertrofičnih glomerula bila je u III starosnoj grupi, naspram druge dve grupe (p ≤ 0,0001), kao i u II grupi u odnosu na I grupu (p ≤ 0,0001). Morfometrijska analiza morfološki normalnih glomerula treba da bude od najveće važnosti za transplantaciju, a ne samo procena njihovog ukupnog broja i broja detektovanih manifestno sklerotičnih glomerula.
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O članku

jezik rada: engleski
vrsta rada: originalan članak
DOI: 10.5633/amm.2021.0203
objavljen u SCIndeksu: 17.06.2021.
metod recenzije: dvostruko anoniman
Creative Commons License 4.0

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