Metrika

  • citati u SCIndeksu: 0
  • citati u CrossRef-u:0
  • citati u Google Scholaru:[]
  • posete u poslednjih 30 dana:9
  • preuzimanja u poslednjih 30 dana:4

Sadržaj

članak: 1 od 2  
Back povratak na rezultate
Osnovni principi farmakogenetičkog testiranja u onkologiji
aVojnomedicinska akademija, Centar za kliničku farmakologiju, Beograd, Srbija
bUniverzitet odbrane, Medicinski fakultet Vojnomedicinske akademije, Beograd, Srbija

e-adresavdragsim@gmail.com
Projekat:
Analiza strukture troškova i uticaja na zdravstveni budžet Republike Srbije epidemiološki najmasovnijih i/ili najskupljih oboljenja i procena odnosa troškovi / efektivnost / korisnost medicinskih intervencija (MPNTR - 175014)
Analiza genskih polimorfirzama CIP izoenzima u populaciji Srbije (MPNTR - 175093)

Ključne reči: farmakogenetika; polymerase chain reaction; sekvencioniranje naredne generacije; sveobuhvatno genomsko profilisanje
Sažetak
Uvod: Precizna medicina je pristup koji prilikom prevencije i lečenja bolesti uzima u obzir genetičke faktore, okruženje i način života. Važan deo precizne medicine je farmakogenetika, deo kliničke farmakologije koji se bavi uticajem genetičkih varijanti na odgovor na lek. Metode: Pošto je onkologija među oblastima u kojima se najviše primenjuje pristup precizne medicine, ovaj članak daje pregled osnovnih principa farmakogenetičkog testiranja prilikom lečenja malignih bolesti. Tema: U radu su razmatrane sledeće teme: uzorci za farmakogenetičko testiranje (periferna krv, biopsija tumora, tečna biopsija), metode koje se primenjuju u farmakogenetičkom testiranju (konvencionalne metode za analizu takozvanih "vrućih mesta" i sveobuhvatno profilisanje genoma), primena sveobuhvatnog profilisanja genoma u kliničkoj praksi i onkološka terapija u Srbiji za koju je neophodno genetičko testiranje. Zaključak: Farmakogenetičko testiranje doprinosi primeni bezbedne i efikasne terapije. Primena CGP metoda dalje otvara mogućnost lečenja na osnovu genetičkim markera nezavisno od anatomskog tipa tumora. Međutim, ovaj pristup zahteva evaluaciju kroz dobro dizajnirana istraživanja i kliničke studije.
Reference
*** (2016) Guideline on good pharmacogenomic practice. EMA/CHMP/718998/2016, https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-good-pharmacogenomic-practice-first-version_en.pdf
Aderhold, K., Wilson, M., Berger, A.C., Levi, S., Bennett, J. (2020) Precision medicine in the treatment of melanoma. Surgical Oncology Clinics of North America, 29(1): 1-13
Atanaskovic, L., Cikota-Aleksic, B., Tarabar, O., Trimcev, J., Zivanovic-Ivic, A., Marjanovic, S., Magic, Z. (2016) Clinical implications of glutathione S-transferase genotyping in patients with diffuse large B-cell lymphoma. Journal of BUON, 21(6): 1459-1465
Collins, F.S., Varmus, H. (2015) A new initiative on precision medicine. New England Journal of Medicine, 372(9): 793-795
Foundation Medicine What is FoundationOne CDx?. https://corpsite.foundationmedicine.com/genomic-testing/foundation-one-cdx
Frampton, G.M., Fichtenholtz, A., Otto, G.A., Wang, K., Downing, S.R., He, J., Schnall-Levin, M., White, J., Sanford, E.M., An, P., Sun, J.P., Juhn, F., Brennan, K., Iwanik, K., Maillet, A., Buell, J., White, E. (2013) Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nature Biotechnology, 31(11): 1023-1031
Iqbal, N., Iqbal, N. (2014) Imatinib: A breakthrough of targeted therapy in cancer. Chemotherapy Research and Practice, 2014: 1-9, 357027
Kwon, D., Kim, B., Shin, H.C., Kim, E.J., Ha, S.Y., Jang, K., Kim, S.T., Lee, J., Kang, W.K., Park, J.O., Kim, K. (2019) Cancer panel assay for precision oncology clinic: Results from a 1-year study. Translational Oncology, 12(11): 1488-1495
Lamping, M., Benary, M., Leyvraz, S., Messerschmidt, C., Blanc, E., Kessler, T., Schütte, M., Lenze, D., Jöhrens, K., Burock, S., Klinghammer, K., Ochsenreither, S., Sers, C., Schäfer, R., Tinhofer, I. (2020) Support of a molecular tumour board by an evidence-based decision management system for precision oncology. European Journal of Cancer, 127: 41-51
Lee, J., Liu, Z., Sa, J.K., Shin, S., Wang, J., Bordyuh, M., Cho, H.J., Elliott, O., Chu, T., Choi, S.W., Rosenbloom, D.I.S., Lee, I.K., Shin, Y.J., Kang, H.J., Kim, D., Kim, S.Y., Sim, M. (2018) Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy. Nature Genetics, Oct; 50(10): 1399-1411
Li, G., Pavlick, D., Chung, J.H., Bauer, T., Tan, B.A., Peguero, J., Ward, P., Kallab, A., Bufill, J., Hoffman, A., Sadiq, A., Edenfield, J., He, J., Cooke, M., Hughes, J., Forcier, B., Nahas, M., Stephens, P. (2019) Genomic profiling of cell-free circulating tumor DNA in patients with colorectal cancer and its fidelity to the genomics of the tumor biopsy. Journal of Gastrointestinal Oncology, 10(5): 831-840
Martens, F.K., Huntjens, D.W., Rigter, T., Bartels, M., Bet, P.M., Cornel, M.C. (2020) DPD testing before treatment with fluoropyrimidines in the Amsterdam UMCs: An evaluation of current pharmacogenetic practice. Frontiers in Pharmacology, 10: 1609-1609
National Health Insurance Fund List of medicines. http://rfzo.rs/index.php/osiguranalica/lekovi-info/lekovi-actual
National Library of Medicine What is precision medicine?. https://ghr.nlm.nih.gov/primer/precisionmedicine/definition
Noske, A., Anders, S., Ettl, J., Hapfelmeier, A., Steiger, K., Specht, K., Weichert, W., Kiechle, M., Klein, E. (2020) Risk stratification in luminal-type breast cancer: Comparison of Ki-67 with EndoPredict test results. Breast, 49: 101-107
Palmirotta, R., Lovero, D., Cafforio, P., Felici, C., Mannavola, F., Pellè, E., Quaresmini, D., Tucci, M., Silvestris, F. (2018) Liquid biopsy of cancer: A multimodal diagnostic tool in clinical oncology. Therapeutic Advances in Medical Oncology, 10: 1-24
Penault-Llorca, F., Kwiatkowski, F., Arnaud, A., Levy, C., Leheurteur, M., Uwer, L., Derbel, O., Le, R.A., Jacquin, J., Jouannaud, C.P., Quenel-Tueux, N., Girre, V., Foa, C. (2020) Decision of adjuvant chemotherapy in intermediate risk luminal breast cancer patients: A prospective multicenter trial assessing the clinical and psychological impact of EndoPredict® (EpClin) use (UCBG 2-14). Breast, 49: 132-140
Rancic, N., Dragojevic-Simic, V., Vavic, N., Kovacevic, A., Segrt, Z., Djordjevic, N. (2016) Economic evaluation of pharmacogenetic tests in patients subjected to renal transplantation: A review of literature. Frontiers in Public Health, 4: 189-189
Rančić, N., Vavić, N., Cikota-Aleksić, B., Magić, Z., Mikov, M., Bokonjić, D., Šegrt, Z., Dragojević-Simić, V. (2018) The relationship between tacrolimus concentration-dose ratio and genetic polymorphism in patients subjected to renal transplantation. Vojnosanitetski pregled, vol. 75, br. 2, str. 147-153
Schrock, A.B., Frampton, G.M., Herndon, D., Greenbowe, J.R., Wang, K., Lipson, D., Yelensky, R., Chalmers, Z.R., Chmielecki, J., Elvin, J.A., Wollner, M., Dvir, A., Gutman, L.S., Bordoni, R., Peled, N., Braiteh, F., Raez, L., Erlich, R., Ou, S.H., Mohamed, M., Ross, J.S. (2016) Comprehensive genomic profiling identifies frequent drug-sensitive EGFR exon 19 deletions in NSCLC not identified by prior molecular testing. Clinical Cancer Research, 22(13): 3281-3285
Suarez-Kurt, G. (2018) Pharmacogenetic testing in oncology: A Brazilian perspective. Clinics, 73(Suppl 1): e565s
Tarabar, O., Cikota-Aleksić, B., Tukić, L., Milanović, N., Aleksić, A., Magić, Z. (2014) Association of interleukin-10, tumor necrosis factor-a and transforming growth factor-b gene polymorphisms with the outcome of diffuse large B-cell lymphomas. International Journal of Clinical Oncology, 19(1): 186-192
U.S. Food and Drug Administration Table of pharmacogenomic biomarkers in drug labeling. Last updated: 12/2019, https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling
Vavić, N., Rančić, N., Cikota-Aleksić, B., Magić, Z., Cimeša, J., Obrenčević, K., Radojević, M., Mikov, M., Dragojević-Simić, V. (2016) The distribution of genetic polymorphism of CYP3A5, CYP3A4 and ABCB1 in patients subjected to renal transplantation. Vojnosanitetski pregled, vol. 73, br. 7, str. 663-667
Wheeler, H.E., Maitland, M.L., Dolan, M. E., Cox, N.J., Ratain, M.J. (2013) Cancer pharmacogenomics: Strategies and challenges. Nature Reviews Genetics, 14(1): 23-34
Yu, B., O'Toole, S.A., Trent, R.J. (2015) Somatic DNA mutation analysis in targeted therapy of solid tumours. Transl Pediatr, 4(2):125-38
 

O članku

jezik rada: engleski
vrsta rada: članak
DOI: 10.5937/hpimj2001895C
objavljen u SCIndeksu: 14.05.2020.
Creative Commons License 4.0

Povezani članci

Nema povezanih članaka