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2021, vol. 149, br. 11-12, str. 737-740
Stres i arterijska hipertenzija - od patofiziologije do farmakologije
aVojnomedicinska akademija, Klinika za endokrinologiju, Beograd
bVojnomedicinska akademija, Klinika za kardiologiju, Beograd
cUniverzitet u Beogradu, Medicinski fakultet, Institut za neurologiju i psihijatriju za decu i omladinu
dUniverzitet u Beogradu, Medicinski fakultet, Institut za neurologiju i psihijatriju za decu i omladinu + Univerzitet u Beogradu, Medicinski fakultet, Institut za farmakologiju, kliničku farmakologiju i toksikologiju

e-adresajanko.samardzic@med.bg.ac.rs
Sažetak
Arterijska hipertenzija je danas najmasovnija hronična nezarazna bolest čovečanstva. Može ostati nedijagnostikovana godinama, što izaziva kasnije komplikacije, poput akutne srčane insuficijencije, moždanog udara, infarkta miokarda, bubrežne insuficijencije, hipertenzivne retinopatije ili iznenadne smrti. Primarna arterijska hipertenzija je češća, dok se sekundarna javlja u oko 5-20% slučajeva. Nedavna istraživanja su pokazala da stres kod nekih pacijenata može biti ključni faktor u razvoju esencijalne hipertenzije. Kod pacijenata koji pate od posttraumatskog stresnog poremećaja, stres je dominantni etiološki faktor koji dovodi do bolesti. Dokazano je da hronični stres može da utiče na regulaciju krvnog pritiska, endokrine i metaboličke funkcije putem limbičko-hipotalamičkih centara i samim tim da utiče na razvoj arterijske hipertenzije. Snažna povezanost stresa i arterijske hipertenzije potvrđena je u pretkliničkim studijama i ispitivanjima na životinjama. Za farmakoterapijski pristup najvažniji su beta-adrenergički blokatori, inhibitori enzima koji konvertuje angiotenzin i blokatori receptora AT1 (sartani). Kao druga linija terapije mogu se koristiti blokatori kalcijumovih kanala, diuretici, alfa-adrenergički blokatori i centralni antihipertenzivi. Uvođenje anksiolitika, poput benzodiazepina, treba razmotriti u slučaju hronične anksioznosti i psihosomatskog poremećaja.
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O članku

jezik rada: engleski
vrsta rada: aktuelni problemi
DOI: 10.2298/SARH210323066N
primljen: 23.03.2021.
revidiran: 06.07.2021.
prihvaćen: 08.07.2021.
objavljen onlajn: 19.07.2021.
objavljen u SCIndeksu: 07.01.2022.