Today, in the era of industrial expansion of developing countries, the Republic of Serbia strives to maintain the required level of progress and join the European Union. On this path of transition, it is necessary to use the comparative advantages in relation to the countries of the region, but also the EU member states. Analysing the available data, it can be established that an important comparative advantage of Serbia lies in the agricultural sector. The aim of this paper is to point out the mentioned comparative advantages, primarily by using the historical-comparative method, and to provide a basis for further decision-making to economic policy makers at the regional and national level. The concept of agricultural and economic policy should be based on the complete revival of agriculture, its revitalization, financial consolidation, innovation and affirmation of the intensification of the production framework.