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2015, vol. 34, br. 2, str. 151-159
Uticaj suplementacije L-karnitinom na nivoe c-reaktivnog proteina u cirkulaciji - sistematski pregled i metaanaliza
Mashhad University of Medical Sciences, Biotechnology Research Center, Mashhad, Iran

e-adresasahebkara@mums.ac.ir
Ključne reči: karnitin; ishrana; koronarna bolest srca; ateroskleroza; sistematični pregled; kliničko ispitivanje
Sažetak
Uvod: C-reaktivni protein (CRP) predložen je kao marker rizika i faktor rizika za kardiovaskularnu bolest. Postoji izvestan broj kliničkih izveštaja koji su pokazali da suplementacija L-karnitinom može modulisati sistemsku inflamaciju i sniziti koncentracije CRP-a u cirkulaciji, ali njihovi rezultati nisu usaglašeni. Metode: U decembru 2012, sprovedena je sveobuhvatna pretraga literature u bazama Medline, Scopus i Cochrane Central Register of Controlled Trials radi identifikacije kliničkih ispitivanja koja su istraživala uticaj oralne suplemen - tacije L-karnitinom na koncentraciju CRP-a u serumu/plazmi. Za izračunavanje kombinovanih dimenzija efekta korišćena je metoda nasumičnog efekta. Rezultati: Šest studija koje su obuhvatile 541 pacijenta i 546 kontrolnih subjekata ispunilo je kriterijume za uključenje u ovu studiju. Metaanalizom obuhvaćenih ispitivanja je otkriveno značajno sniženje koncentracija CRP-a u cirkulaciji kod subjekata podvrgnutih intervenciji L-karnitinom u poređenju s kontrolom. Izračunato kombinovano srednje sniženje koncentracija CRP-a iznosilo je -0,39 mg/L [95% CI(-0,62 - 0,16)]. Ovakva procena dimenzija efekta označena je kao robusna i ostala je nepromenjena i posle odstranjivanja svake pojedinačne studije. Zaključak: Ukupni rezultat predstavljene metaanalize svedoči u prilog klinički relevantne koristi od suplementacije L-karnitinom za snižavanje nivoa CRP u cirkulaciji.
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jezik rada: engleski
vrsta rada: izvorni naučni članak
PMC ID: PMC4922328
DOI: 10.2478/jomb-2014-0030
objavljen u SCIndeksu: 03.01.2020.