Metrics

  • citations in SCIndeks: 0
  • citations in CrossRef:[3]
  • citations in Google Scholar:[]
  • visits in previous 30 days:7
  • full-text downloads in 30 days:2

Contents

article: 1 from 1  
Back back to result list
2015, vol. 34, iss. 2, pp. 151-159
Effect of L-carnitine supplementation on circulating C-reactive protein levels: A systematic review and meta-analysis
Mashhad University of Medical Sciences, Biotechnology Research Center, Mashhad, Iran

emailsahebkara@mums.ac.ir
Abstract
Background: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower circulating CRP concentrations, but the results have not been consistent. Methods: A comprehensive literature search in Medline, Scopus and Cochrane Central Register of Controlled Trials was performed in December 2012 to identify clinical trials investigating the impact of oral L-carnitine supplementation on serum/plasma CRP concentration. A random effect method was used to calculate the combined effect size. Results: Six studies comprising 541 cases and 546 controls met the inclusion criteria. Meta-analysis of included trials revealed a significant reduction of circulating CRP concentrations in subjects under L-carnitine intervention compared to the control treatment. The calculated combined weighted mean reduction in CRP concentrations was -0.39 mg/L [95% CI (-0.62 - -0.16)]. This effect size estimate was found to be robust and remained unaffected by the removal of each single study. Conclusions: The overall findings of the present metaanalysis support the clinically relevant benefit of L-carnitine supplementation in lowering the circulating levels of CRP.
References
Abd-Allah, A.R.A., Al-Majed, A.A., Al-Yahya, A.A., Fouda, S.I., Al-Shabana, O.A. (2005) L-Carnitine halts apoptosis and myelosuppression induced by carboplatin in rat bone marrow cell cultures (BMC). Archives of Toxicology, 79(7): 406-413
Arsenian, M.A. (1997) Carnitine and its derivatives in cardiovascular disease. Progress in Cardiovascular Diseases, 40(3): 265-286
Bellinghieri, G., Santoro, D., Calvani, M., Savica, V. (2005) Role of carnitine in modulating acute-phase protein synthesis in hemodialysis patients. Journal of Renal Nutrition, 15(1): 13-17
Bloomer, R.J., Fisher-Wellman, K.H., Tucker, P.S. (2009) Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics. Nutrition & Metabolism, 6(1): 25-25
Bremer, J. (1983) Carnitine metabolism and functions. Physiological Reviews, 63(4): 1420-1480
Buyse, J., Swennen, Q., Niewold, T.A., Klasing, K.C., Janssens, G.P.J., Baumgartner, M., Goddeeris, B.M. (2007) Dietary l-carnitine supplementation enhances the lipopolysaccharide-induced acute phase protein response in broiler chickens. Veterinary Immunology and Immunopathology, 118(1-2): 154-159
Collins, A.J., Shuling, L., Ma, J.Z., Herzog, C. (2001) Cardiovascular disease in end-stage renal disease patients. American Journal of Kidney Diseases, 38(4): S26-S29
Danesh, J., Wheeler, J.G., Hirschfield, G.M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G.D.O., Pepys, M.B., Gudnason, V. (2004) C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease. New England Journal of Medicine, 350(14): 1387-1397
de Rosa, M., Boggia, B., Amalfi, B., Zarrilli, S., Vita, A., Colao, A., et al. (2005) Correlation between seminal carnitine and functional spermatozoal characteristics in men with semen dysfunction of various origins. Drug R&D, 6: 1-9
Derosa, G., Maffioli, P., Ferrari, I., Palumbo, I., Randazzo, S., D'angelo, A., Cicero, A.F.G. (2011) Variation of inflammatory parameters after sibutramine treatment compared to placebo in type 2 diabetic patients. Journal of Clinical Pharmacy and Therapeutics, 36(5): 592-601
Derosa, G., Maffioli, P., Salvadeo, S.A.T., Ferrari, I., Gravina, A., Mereu, R., D'angelo, A., Palumbo, I., Randazzo, S., Cicero, A.F.G. (2011) Effects of combination of sibutramine and l-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients. Metabolism, 60(3): 421-429
Derosa, G., Maffioli, P., Ferrari, I., D'angelo, A., Fogari, E., Palumbo, I., Randazzo, S., Cicero, A.F.G. (2010) Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients. Endocrine Journal, 57(9): 777-786
Dong, J.Y., Wang, P., He, K., Qin, L.Q. (2011) Effect of soy isoflavones on circulating C-reactive protein in post-menopausal women: Meta-analysis of randomized controlled trials. Menopause, 18: 1256-62
Duranay, M., Akay, H., Yilmaz, F.M., Senes, M., Tekeli, N., Yucel, D. (2006) Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. Nephrology Dialysis Transplantation, 21(11): 3211-3214
Ferrari, R., Merli, E., Cicchitelli, G., Mele, D., Fucili, A., Ceconi, C. (2004) Therapeutic Effects of l-Carnitine and Propionyl-l-carnitine on Cardiovascular Diseases: A Review. Annals of the New York Academy of Sciences, 1033(1): 79-91
Flanagan, J.L., Simmons, P.A., Vehige, J., Willcox, M.D., Garrett, Q. (2010) Role of carnitine in disease. Nutrition & Metabolism, 7(1): 30-30
Foley, R.N., Parfrey, P.S., Sarnak, M.J. (1998) Clinical epidemiology of cardiovascular disease in chronic renal disease. American Journal of Kidney Diseases, 32(5): S112-S119
Foster, D.W. (2004) The Role of the Carnitine System in Human Metabolism. Annals of the New York Academy of Sciences, 1033(1): 1-16
Fu, R.G., Wang, L., Zhou, J.G., Ma, F., Liu, X.D., Ge, H., et al. (2010) The effect of levocarnitine on nutritional status and lipid metabolism during long-term maintenance hemodialysis. Academic Journal of Xi'an Jiaotong University, 22: 203-240
Greenland, P., Alpert, J.S., Beller, G.A., Benjamin, E.J., Budoff, M.J., Fayad, Z.A., Foster, E., Hlatky, M.A., Hodgson, J.M., Kushner, F.G., Lauer, M.S., Shaw, L.J., Smith, S.C., Taylor, A.J., Weintraub, W.S., Wenger, N.K., Jacobs, A.K., Members Writing Committee (2010) 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation, 122(25): e584-e636
Hakeshzadeh, F., Tabibi, H., Ahmadinejad, M., Malakoutian, T., Hedayati, M. (2010) Effects of L-Carnitine supplement on plasma coagulation and anticoagulation factors in hemodialysis patients. Renal Failure, 32(9): 1109-1114
Hansson, G.K., Robertson, A.K., Sôderberg-Nauclér, C. (2006) Inflammation and atherosclerosis. Annual Review of Pathology, 1: 297-329
Hao, P.P., Chen, Y.G., Wang, X.L., Xu, F., Wang, J.L., Zhang, Y. (2009) A meta-analysis of the effects of statins on serum C-reactive protein in Chinese population with coronary heart disease or hyperlipidemia. Chinese Science Bulletin, 54(23): 4404-4410
He, Z.F., Liu, F., Zhai, S.D., Wu, X.A., Wang, T., Liang, L. (2009) Statins therapy for C-reactive protein and carotid intima-media thickness in patients with cerebral infarction: A systematic review. Chinese Journal of Evidence-Based Medicine, 9: 873-882
Higgins, J.P.T., Green, S., eds. (2009) Cochrane handbook for systematic reviews of interventions. The Cochrane Collboration, Version 5.0.2
Iliceto, S., Scrutinio, D., Bruzzi, P., D'ambrosio, G., Boni, L., di Biase, M., Biasco, G., Hugenholtz, P.G., Rizzon, P. (1995) Effects of l-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: The l-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) trial. Journal of the American College of Cardiology, 26(2): 380-387
Jadad, A.R., Moore, A.R., Carroll, D., Jenkinson, C., Reynolds, J.D.M., Gavaghan, D.J., McQuay, H.J. (1996) Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Controlled Clinical Trials, 17(1): 1-12
Kaptoge, S., di Angelantonio, E., Lowe, G., Pepys, M.B., Thompson, S.G., Collins, R., Danesh, J., Emerging Risk Factors Collaboration (2010) C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis. Lancet, 375(9709): 132-140
Liu, J., Head, E., Kuratsune, H., Cotman, C.W., Ames, B.N. (2004) Comparison of the Effects of l-Carnitine and Acetyl-l-Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats. Annals of the New York Academy of Sciences, 1033(1): 117-131
Malaguarnera, M., Gargante, M.P., Russo, C., Antic, T., Vacante, M., Malaguarnera, M., Avitabile, T., Li, V.G., Galvano, F. (2010) L-Carnitine Supplementation to Diet: A New Tool in Treatment of Nonalcoholic Steatohepatitis: A Randomized and Controlled Clinical Trial. American Journal of Gastroenterology, 105(6): 1338-1345
Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G. (2009) Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ, 339(jul21 1): b2535-b2535
Mortazavi, M., Asgari, S., Ghassami, M., Seirafian, S., Taheri, S., Naini, A.E., et al. (2011) The effect of oral L-carnitine on serum albumin and inflammatory markers levels in patients under peritoneal dialysis: A randomized controlled trial. Journal of Isfahan Medical School, 29: 546-54
Nakou, E.S., Liberopoulos, E.N., Milionis, H.J., Elisaf, M.S. (2008) The Role of C-Reactive Protein in Atherosclerotic Cardiovascular Disease: An Overview. Current Vascular Pharmacology, 6(4): 258-270
Nilsson, J. (2005) CRP-Marker or Maker of Cardiovascular Disease?. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(8): 1527-1528
Paoletti, R., Gotto, A., Hajjar, D.P. (2004) Inflammation in Atherosclerosis and Implications for Therapy. Circulation, 109(23_suppl_1): III-20-III-26-III-20-III-26
Pepys, M.B., Hirschfield, G.M. (2003) C-reactive protein: A critical update. Journal of Clinical Investigation, 111(12): 1805-1812
Popović, L., Lalić, K., Vasović, O., Drašković-Radojković, D., Rajković, N., Singh, S., Stošić, L., Čivčić, M., Škorić-Hinić, L., Petrović-Vujić, T. (2014) C-reactive protein predicts progression of peripheral arterial disease in patients with type 2 diabetes: A 5-year follow-up study. Journal of Medical Biochemistry, vol. 33, br. 4, str. 347-355
Retter, A.S. (1999) Carnitine and its role in cardiovascular disease. Heart disease, 1: 108-121
Ridker, P.M., Danielson, E., Fonseca, F.A., Genest, J., Gotto, A.M., Kastelein, J.J., Koenig, W., Libby, P., Lorenzatti, A.J., Macfadyen, J.G., Nordestgaard, B.G., Shepherd, J., Willerson, J.T. (2009) Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial. Lancet, 373(9670): 1175-1182
Sahebkar, A. (2013) Does PPARg2 Gene Pro12Ala Polymorphism Affect Nonalcoholic Fatty Liver Disease Risk? Evidence from a Meta-Analysis. DNA and Cell Biology, 32(4): 188-198
Savica, V., Calvani, M., Benatti, P., Santoro, D., Monardo, P., Peluso, G., Bellinghieri, G. (2004) Carnitine system in uremic patients: Molecular and clinical aspects. Seminars in Nephrology, 24(5): 464-468
Savica, V., Santoro, D., Mazzaglia, G., Ciolino, F., Monardo, P., Calvani, M., Bellinghieri, G., Kopple, J.D. (2005) L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients. Journal of Renal Nutrition, 15(2): 225-230
Shakeri, A., Tabibi, H., Hedayati, M. (2010) Effects of l-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. Hemodialysis International, 14(4): 498-504
Suchitra, M.M., Ashalatha, V.L., Sailaja, E., Rao, A.M., Reddy, V.S., Bitla, A.R., et al. (2011) The effect of L-carnitine supplementation on lipid parameters, inflammatory and nutritional markers in maintenance hemodialysis patients. Saudi journal of kidney diseases and transplantation, 22: 1155-1164
Takagi, H., Yamamoto, H., Iwata, K., Goto, S.N., Umemoto, T. (2012) Effects of telmisartan on C-reactive protein levels: A meta-analysis of randomized controlled trials. International Journal of Cardiology, 156(2): 238-241
Ye, J., Kiage, J.N., Arnett, D.K., Bartolucci, A.A., Kabagambe, E.K. (2011) Short-term effect of fenofibrate on C-reactive protein: A meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome, 3(1): 24-24
Yeh, E.T., Anderson, H.V., Pasceri, V., Willerson, J.T. (2001) C-reactive protein: Linking inflammation to cardiovascular complications. Circulation, 104(9): 974-5
Yesilbursa, D., Serdar, A., Heper, Y., Sarac, M., Coskun, S., Kazazoglu, A.R., Cordan, J. (2005) The effect of orlistat-induced weight loss on interleukin-6 and C-reactive protein levels in obese subjects. Acta Cardiologica, 60(3): 265-269
 

About

article language: English
document type: Original Scientific Paper
PMC ID: PMC4922328
DOI: 10.2478/jomb-2014-0030
published in SCIndeks: 03/01/2020