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The impact of co/polymorbidity on the therapeutic response to vitamin D in patients with osteoporosis and vitamin D hypovitaminosis in primary health care
aUniversity of Kragujevac, Faculty of Medical Sciences
bUniversity of Kragujevac, Faculty of Science
cUniversity of Kragujevac, Faculty of Medical Sciences + Clinical Center Kragujevac
dUniversity of Kragujevac, Faculty of Medical Sciences + Opšta bolnica, Novi Pazar
eUniversity of Kragujevac, Faculty of Medical Sciences + Clinical Center of Serbia, Belgrade
Keywords: vitamin D; Detrical®1000; osteoporosis; co / polymorbidities
Introduction: Vitamin D, its active metabolites and analogs, represent a group of compounds with numerous functions in the body. The activated receptor for vitamin D in the intestines stimulates the synthesis of the binding protein for calcium, bone stimulates the production of osteocalcin, osteoponin, alkaline phosphatase, increases the transport of calcium from vancellular to intracellular cells, can mobilize calcium from the intracellular calcium reservoir and enhance the metabolism of phosphatidylinositol. Objective: The aim of this paper is to examine the possible cause-and-effect linkages between the therapeutic response and the use of vitamin D and additional diseases and therapies in primary health care patients with vitamin D deficiency and osteoporosis. Material and method: Epidemiological survey of osteoporosis and hypovitaminosis D vitamins, was conducted as a retrospective study in patients in primary health care of the Health Kragujevac, after receiving the decision of the Ethics Committee of the Health Center Kragujevac. In the period from 01. 02. 2018. to 22. 10. 2019. an study was conducted, in which patients with various diseases, ages 30 to 65, were administered vitamin D (Detrical® 1000), and levels of serum D vitamins were measured before and after therapy. Results: Statistically significant differences in the response to vitamin D (Detrical®1000) were observed in patients with hypertension, diabetes and thyroid disorders (p < 0.05). The results obtained also indicate, that there are statistically significant differences in patients with hypertension treated with combination therapy with ACE inhibitor and diuretic (p < 0.05). T-assay of samples showed a statistically significant increase in the level of vitamin D in the subjects after treatment with Detrical® (p < 0.0001). Conclusion: Ensuring adequate vitamin D intake is a key ingredient in the treatment of osteoporosis. People at high risk of developing fractures benefit from taking vitamin D supplementation, at least 800 IJ per day. By entering one tablet daily, Detrical®1000, a better neuromuscular function is achieved.
Arfian, N., et al. (2016) Vitamin D attenuates kidney fibrosis via reducing fibroblast expansion, inflammation, and epithelial cell apoptosis. 62(2), 38-44
Autier, P., Boniol, M., Pizot, C., Mullie, P. (2014) Vitamin D status and ill health: A systematic review. Lancet Diabetes & Endocrinology, 2(1), 76-89
Bo, S., Ponzo, V., Evangelista, A., Ciccone, G., Goitre, I., Saba, F., Procopio, M., Cassader, M., Gambino, R. (2017) Effects of 6 months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: A double-blind randomized controlled trial. Acta Diabetologica, 54(5), 499-507
Dalle, C.L., Valenti, M., Del, F.F., Piacentini, G., Pietrobelli, A. (2018) Vitamin D daily versus monthly administration: Bone turnover and adipose tissue influences. Nutrients, 10(12), 1934
Deluca, H. (2014) History of the discovery of vitamin D and its active metabolites. BoneKEy Reports, 3, 479
Holick, M. (2008) Vitamin D: A D-light full health perspective. Nutrition Reviews, 66(Suppl2), S182-S194
Holick, M.F. (2007) Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281
Holick, M.F. (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. American Journal of Clinical Nutrition, 80(6 Suppl), 1678S-88S
Kimball, S., Fuleihan, G.E., Vieth, R. (2008) Vitamin D: A growing perspective. Critical Reviews in Clinical Laboratory Sciences, 45(4), 339-414
Mihajlović, F., Milosavljević, A., Đurić, D. (2016) Taksonomske nedoumice upotrebe termina za označavanje istovremene prisutnosti i povezanosti više bolesti kod pacijenata. PONS - medicinski časopis, vol. 13, br. 2, str. 64-70
Płudowski, P., Karczmarewicz, E., Bayer, M., et al. (2013) Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groupsat risk of vitamin D deficiency. Endokrynologia Polska, 64(4), 319-327
Radlović, N., Mladenović, M., Simić, D., Radlović, P. (2012) Vitamin D in the light of current knowledge. Srpski arhiv za celokupno lekarstvo, vol. 140, br. 1-2, str. 110-114
Simona, B. (2018) Effects of resveratrol on bone health in type 2 diabetic patients: A double-blind randomized-controlled trial. (8), 51-53


article language: Serbian, English
document type: unclassified
DOI: 10.5937/medgla2078023M
published in SCIndeks: 29/09/2020
Creative Commons License 4.0

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